Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women

Bayraktar, Mehmet; Özerol, İbrahim Halil; Güçlüer, Nilay; Çelik, Önder

doi:10.1016/j.ijid.2009.03.020

Cited by 118 publications

(126 citation statements)

References 26 publications

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“…In addition, regarding the genotyped ureaplasma isolates, where 72.2% of UU isolates were resistant to ciprofloxacin, it can be concluded that quinolones are not the best choice for treatment of ureaplasma isolates. These findings are consistent with research of Baryaktar et al [23] who estimated higher resistance to quinolones of UU, i.e. 86.2% to ofloxacin and 92.6% to ciprofloxacin.…”

Section: Discussionsupporting

confidence: 93%

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Ureaplasma urealyticum and Ureaplasma parvum in women of reproductive age

Hunjak¹,

Sabol

Vojnović³

et al. 2013

Arch Gynecol Obstet

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Objectives. To determine the incidence of Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP) in symptomatic and asymptomatic women of reproductive age and to estimate antibiotic susceptibility of ureaplasma isolates.Material and methods. This study included 424 ureaplasma positive women of 1370 tested women who visited gynecological practices during 2010. Cervicovaginal or urethral swab specimens from each patient were obtained for cultivation and molecular typing by RT-PCR.Results. Ureaplasma spp. was identified by cultivation in 424 (34.4%) cases, of which 79.0%were from women with symptoms and 21.0% from women without symptoms. Among ureaplasma positive women, 121 (28.5%) were pregnant. Genotyping was successful in 244 strains, and the majority of samples were identified as UP (92.6%). Among genotyped isolates, there were 79.5% from symptomatic and 20.5% from asymptomatic women; 29.9% from pregnant and 70.1% from non-pregnant women. There was no difference in the incidence of ureaplasma type regarding symptoms. Antibiotic susceptibility of 424 ureaplasma isolates identified by cultivation showed that all strains were susceptible to doxycycline, josamycin, erythromycin, tetracycline, clarithromycin and pristinamicin, but there was lower susceptibility to quinolone antibiotics, i.e. 42.9% and 24.5% isolates were susceptible to ofloxacin and ciprofloxacin, respectively.Conclusion. This study shows that UP was the most frequent isolated ureaplasma species (92.6%). Regarding antibiotic susceptibility, quinolones are not the best choice for treatment of ureaplasma infections, while macrolides and tetracyclines are still effective.

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Section: Discussionsupporting

confidence: 93%

“…There are evidence of adverse impact of ureaplasma infection on the course and outcome of pregnancy [2,4], and that ureaplasma infection in infants is associated with low birth weight and perinatal mortality [23]. Govender et al [24] established ureaplasma high prevalence among women aged ≥ 26 years.…”

Section: Discussionmentioning

confidence: 99%

Ureaplasma urealyticum and Ureaplasma parvum in women of reproductive age

Hunjak¹,

Sabol

Vojnović³

et al. 2013

Arch Gynecol Obstet

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“…However, since they are found in the vagina of up to 80% of pregnant and non-pregnant women [7], their pathogenic role is difficult to prove.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Mycoplasma IES, Mycofast Revolution and Mycoplasma IST2 to detect genital mycoplasmas in clinical samples

D’Inzeo

Angelis

Fiori

et al. 2017

J Infect Dev Ctries

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Introduction: Culture is regarded as the gold standard for the detection of genital mycoplasma in clinical samples. Commercially available diagnostic kits, based on liquid broth cultures, provide interesting alternatives to conventional culture. We assessed the laboratory performances of Mycoplasma IES (IES), the Mycofast Revolution (REV) and Mycoplasma IST 2 (IST2) compared to A7 agar plates for the detection of Ureaplasma urealyticum and Mycoplasma hominis in clinical samples. Methodology: From April to July 2013, endocervical or vaginal samples were collected from sexually active women with abnormal vaginal discharge. Each specimen was tested in parallel using the three commercial kits and the A7 agar plates. Results: A total of 303 samples were included in this study, 35.6% (108/303) of which were positive on A7 plates. Sensitivities for the detection of U. urealyticum of IES, REV and IST2 were 100%, 96.2% and 95.3%, respectively while those for M. hominis were of 92.8%, 92.8% and 85.7%, respectively. Specificity was 100% for the 3 methods. Concerning antimicrobial susceptibility testing, full agreement between IES and REV was documented. Conclusions: The Mycoplasma IES kit was found to be equivalent or superior compared to other commercial culture-based assays for a rapid and accurate identification of U. urealyticum and M. hominis and detection of resistance. It might be considered a cost-effective tool for detection of these organisms, particularly attractive in developing countries.

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“…Antibiotic treatment for suspected or confirmed Ureaplasma infection has generally consisted of erythromycin (15)(16)(17); however, this drug has failed to prevent (18) or treat infection (19). Recently, several studies have reported the variable sensitivity of Ureaplasma to antibiotics (20,21), and some small studies have found azithromycin (23) or clarithromycin (24) to be effective for treatment of chronic lung disease. A Cochrane review suggests that controlled trials are required to determine whether (and which) antibiotic therapy of Ureaplasma reduces infection or death in preterm infants (18).…”

Section: Discussionmentioning

confidence: 99%

“…However, it failed to prevent infection in 17 studies (18) and failed as treatment in five studies (19). More recently, several studies have reported on the variable sensitivity of Ureaplasma to antibiotics (20,21). A recent Cochrane review suggested that controlled trials are required to determine whether antibiotic therapy of Ureaplasma reduces infection or death in preterm infants (18).…”

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confidence: 99%

Appropriate antibiotic therapy improves Ureaplasma sepsis outcome in the neonatal mouse

2012

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Background: Ureaplasma causes sepsis in human neonates. although erythromycin has been the standard treatment, it is not always effective. No published reports have evaluated Ureaplasma sepsis in a neonatal model. We hypothesized that appropriate antibiotic treatment improves Ureaplasma sepsis in a neonatal mouse model. Methods: Two aTcc strains and two clinical strains of Ureaplasma were evaluated in vitro for antibiotic minimum inhibitory concentration (MIc). In addition, FVB albino mice pups infected with Ureaplasma were randomly assigned to saline, erythromycin, or azithromycin therapy and survival, quantitative blood culture, and growth were evaluated. results: MIcs ranged from 0.125 to 62.5 µg/ml and 0.25 to 1.0 µg/ml for erythromycin and azithromycin, respectively. The infecting strain and antibiotic selected for treatment appeared to affect survival and bacteremia, but only the infecting strain affected growth. azithromycin improved survival and bacteremia against each strain, whereas erythromycin was effective against only one of four strains. conclusion: We have established a neonatal model of Ureaplasma sepsis and observed that treatment outcome is related to infecting strain and antibiotic treatment. We speculate that appropriate antibiotic selection and dosing are required for effective treatment of Ureaplasma sepsis in neonates, and this model could be used to further evaluate these relationships.

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Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women

Abstract: It can be concluded that genital colonization with M. hominis and U. urealyticum may predispose to spontaneous abortion and low birth weight.

Cited by 118 publications

References 26 publications

Ureaplasma urealyticum and Ureaplasma parvum in women of reproductive age

Ureaplasma urealyticum and Ureaplasma parvum in women of reproductive age

Comparison of Mycoplasma IES, Mycofast Revolution and Mycoplasma IST2 to detect genital mycoplasmas in clinical samples

Appropriate antibiotic therapy improves Ureaplasma sepsis outcome in the neonatal mouse

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