Prevalence and antibiotic susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae in Estonian intensive care units in comparison with European data

Lõivukene, Krista; Sepp, Epp; Adamson, Vivika; Mitt, Piret; Kallandi, Ü; Otter, Karin; Naaber, Paul

doi:10.1080/00365540600786507

Cited by 12 publications

(9 citation statements)

References 15 publications

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“…AMS has comparable activity to AMP against bacteria that are resistant to ␤-lactam antibiotics as a result of mechanisms other than ␤-lactamase production [17], such as S. pneumoniae. Table 1 summarises recent AMS susceptibility data [19][20][21][22][23][24].…”

Section: Microbiology and In Vitro Activitymentioning

confidence: 99%

Rational antibiotic therapy and the position of ampicillin/sulbactam

Lode

2008

International Journal of Antimicrobial Agents

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Section: Microbiology and In Vitro Activitymentioning

confidence: 99%

Rational antibiotic therapy and the position of ampicillin/sulbactam

Lode

2008

International Journal of Antimicrobial Agents

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“…Furthermore, in the MYSTIC report from 48 European hospitals for isolates from the period of 2002 to 2004 (38), 27% and 30% of isolates were resistant to meropenem and imipenem, respectively. Therefore, such high percentages of resistance in the current study, compared to the previous findings in Taiwan as well as in other countries (16,21,27,38), may suggest that the prevalence of the isolates in the A. calcoaceticus-A. baumannii complex that are resistant to carbapenems has recently been increasing in Taiwan.…”

Section: Discussionmentioning

confidence: 38%

“…Previous studies conducted in intensive care units (ICUs) of several teaching hospitals in Taiwan had already indicated that the percentage of resistance to imipenem in A. baumannii was increasing, from 22% in 2000 to 25% in 2005 (16,21). In other countries, such as Estonia, 5% of A. baumannii strains were resistant to meropenem and imipenem (27). Furthermore, in the MYSTIC report from 48 European hospitals for isolates from the period of 2002 to 2004 (38), 27% and 30% of isolates were resistant to meropenem and imipenem, respectively.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Genospecies and Antimicrobial Resistance Profiles of Isolates in the Acinetobacter calcoaceticus-Acinetobacter baumannii Complex from Various Clinical Specimens

Tien

You

Chang

et al. 2012

Antimicrob Agents Chemother

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gThis study was conducted to compare the prevalences of antimicrobial resistance profiles of clinical isolates in the Acinetobacter calcoaceticus-Acinetobacter baumannii complex from sterile and nonsterile sites and to further study the relationship of antimicrobial resistance profiles and genospecies by amplified rRNA gene restriction analysis (ARDRA). A total of 1,381 isolates were tested with 12 different antibiotics to show their antimicrobial susceptibility profiles. A total of 205 clinical isolates were further analyzed by ARDRA of the intergenic spacer (ITS) region of the 16S-23S rRNA gene. It was found that the overall percentage of isolates from nonsterile sites (urine, sputum, pus, or catheter tip) that were resistant to the 12 antibiotics tested was significantly higher than that of isolates from sterile sites (cerebrospinal fluid [CSF], ascites fluid, and bloodstream) (46% versus 22%; P < 0.05). After ARDRA, it was found that 97% of the 62 isolates resistant to all antibiotics tested were the A. baumannii genospecies, which was identified in only 31% of the isolates susceptible to all antibiotics tested. More genospecies diversity was identified in the isolates susceptible to all antibiotics tested, including genospecies of 13TU (34%), genotype 3 (29%), and A. calcoaceticus (5%). Furthermore, as 91% (10/11) of the isolates from CSF were susceptible to all antibiotics tested, the A. calcoaceticus-A. baumannii complex isolates with multidrug resistance could be less invasive than the more susceptible isolates. This study also indicated current emergence of carbapenem-, fluoroquinolone-, aminoglycoside-, and cephalosporin-resistant A. calcoaceticus-A. baumannii complex isolates in Taiwan.

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“…As the collection contained a large number of Pseudomonas strains, and increased carbapenem resistance is a problem in Estonian medical settings [37], we included a member of this group of antibiotics, meropenem, in the resistance testing.…”

Section: Resultsmentioning

confidence: 99%

Co-occurrence of resistance to different antibiotics among aquatic bacteria

et al. 2012

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BackgroundAntibiotic resistance is not confined to pathogens, but is also widespread in various natural environments. In nature the microbes producing antibiotic compounds have been around for millions of years. Heavy use of antibiotics in medicine and veterinary practice may lead to the accumulation of resistance genes in microbial populations, followed by a rise in multiresistant bacteria.ResultsTo test the extent of resistance among aquatic bacteria, we have collected 760 isolates resistant to at least one antibiotic. The phylogeny of the isolates covers a wide range of Proteobacteria, Actinobacteria and Bacteroidetes. In order to determine the extent of multiresistance, the isolates were tested on six antibiotics. As the growth rate of the different bacteria was highly variable, the classical medical resistance tests could not be used, and an alternative method considering the full growth curve was developed. In general, the overall resistances to different antibiotics could be explained by random, independent distribution. An exception to this was the resistances against tetracycline and chloramphenicol, which tended to occur in pairs.ConclusionsWe conclude that there is no massive spread of multiresistance determinants in the studied environment, although some specific cases can be found, awaiting for molecular characterization of the resistance mechanisms.

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Prevalence and antibiotic susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae in Estonian intensive care units in comparison with European data

Cited by 12 publications

References 15 publications

Rational antibiotic therapy and the position of ampicillin/sulbactam

Rational antibiotic therapy and the position of ampicillin/sulbactam

Comparison of Genospecies and Antimicrobial Resistance Profiles of Isolates in the Acinetobacter calcoaceticus-Acinetobacter baumannii Complex from Various Clinical Specimens

Co-occurrence of resistance to different antibiotics among aquatic bacteria

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