Prevalence and antimicrobial susceptibility of respiratory pathogens in patients with cystic fibrosis

Abstract

Respiratory infection is very common in patients suffering from cystic fi brosis (CF). However, the antimicrobial resistance rate of isolates from CF patients is not often documented. In this study, 279 respiratory specimens of 146 patients were prospectively collected from July to December 2006. Microbiological cultures and antimicrobial susceptibility tests of the most frequently isolated bacteria were performed. Sputum and oropharyngeal swabs were processed for culture. During the study period, 50% of the patients harbored Staphylococcus aureus, 35% Pseudomonas aeruginosa, 4.7% Haemophilus infl uenzae. Methicillin resistant S. aureus (MRSA) were detected in 8 (6%) patients; ESBL and MBL-producing P. aeruginosa were not identifi ed in these patients. The detection of MRSA in CF patients confi rms that antimicrobial resistance patterns should be always kept under surveillance. Moreover, hygiene regulations in CF clinics should prevent a further spread of resistant bacterial strains.

Desfechos clínicos associados à identificação de Staphylococcus aureus resistente à meticilina (MRSA) em secreção respiratória de lactentes e pré-escolares com fibrose cística

“…Em decorrência do defeito genético ocorre um comprometimento do transporte mucociliar e , portanto, da função de clearance da via aérea, predispondo, por consequência, à colonização bacteriana e à infecções crônicas, principalmente por agentes como Staphylococcus aureus e Pseudomonas aeruginosa (25).…”