Prevalence and antimicrobial susceptibility of<i>Ureaplasma</i>species and<i>Mycoplasma hominis</i>in Greek female outpatients, 2012–2016

Maraki, Sofia; Mavromanolaki, Viktoria Eirini; Nioti, Eleni; Stafylaki, Dimitra; Minadakis, Georgios

doi:10.1080/1120009x.2017.1404287

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…(25.7%), in agreement with other studies. 7,[40][41][42] However, Mh infection did not manifest the high bacterial loads expected as a result of the association with BV. 43 With 68.6% of the samples with <10 4 CFU/ml, our results indicated that BV was associated with the type of genital mycoplasma but not with the bacterial load.…”

Section: Discussionmentioning

confidence: 86%

Genital mycoplasma infection and spontaneous preterm birth outcome: a prospective cohort study

Cunha

Bastos

Freitas

et al. 2021

BJOG

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Objective To assess the risk of spontaneous preterm birth (sPTB) associated with genital mycoplasma infection in asymptomatic women.Design Prospective cohort.Setting Public and private health services in Ribeirão Preto, SP, Brazil.Population A cohort of 1349 asymptomatic women with a singleton pregnancy at 20-25 weeks of gestation.Methods Participants completed a sociodemographic and clinical history questionnaire during the prenatal visit and provided cervicovaginal samples for the evaluation of Mycoplasma hominis (Mh), Ureaplasma spp. and bacterial vaginosis (BV). For gestational outcome, information about the delivery was assessed and sPTB was defined as a birth that occurred before 37 weeks of gestation. The association between variables and the risk of sPTB was evaluated using logistic regression analysis to estimate the odds ratios (ORs). Main outcome measures Genital mycoplasma infection and prematurity.Results The prevalence of sPTB and genital mycoplasma was 6.8 and 18%, respectively. The infection was not a risk factor for sPTB (aOR 0.66, 95% CI 0.32-1.35), even when Mh and Ureaplasma spp. were found together (P = 0.83). Pregnant women with genital mycoplasma infections had greater BV (P < 0.0001), but this vaginal microbiota condition was not associated with sPTB (P = 0.35). Regarding the risk factors associated with sPTB, a previous history of sPTB (aOR 12.06,) and a cervical length of ≤2.5 cm (aOR 3.97, 95% CI 1.67-9.47) were significant.Conclusions Genital mycoplasma infection was not a risk factor for sPTB, even in the presence of other abnormal vaginal microbiota.

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Section: Discussionmentioning

confidence: 86%

Genital mycoplasma infection and spontaneous preterm birth outcome: a prospective cohort study

Cunha

Bastos

Freitas

et al. 2021

BJOG

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“…Doxycycline was proved the most active choice for the treatment of Mycoplasma hominis . 13 , 14 Quinolones or tetracyclines were active against Mycoplasma hominis and moxifloxacin appeared to have the greatest activity as the most effective therapeutic agent. 15 The patient in our case therefore switched to the right regimen of the combination of moxifloxacin and doxycycline with a marked improvement of clinical syndromes and a favorable result.…”

Section: Discussionmentioning

confidence: 99%

Periprosthetic Joint Infection Caused by Mycoplasma hominis, Diagnosed Using Metagenomic Sequencing

Wang¹,

Ren²,

Li³

et al. 2021

IJGM

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To our knowledge, the periprosthetic joint infection (PJI) caused by Mycoplasma hominis is a rare postoperative complication after total knee arthroplasty (TKA). Just a few cases associated with Mycoplasma hominis infection after TKA were reported all over the world currently. In view of the difficulty involved in isolating this microorganism, Mycoplasma hominis infection may be under-recognized and should be considered in culture-negative cases where the microbial etiology is not easily identified. Metagenomic sequencing is a new tool to identify pathogens undetected by conventional methods. In this report, we present a case where metagenomic sequencing was used to identify Mycoplasma hominis as a novel PJI pathogen after TKA in our hospital.

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“…El aumento de resistencia a macrólidos por parte de Ureaplasma urealyticum ha sido reportado en diversas partes del mundo, lo que ha generado una preocupación en relación a la reducción del arsenal terapéutico en el caso de las embarazadas, en quienes está contraindicado el uso de tetraciclinas, y en relación a quinolonas (categoría C de la Food and Drugs Administration, FDA) son contraindicadas por muchos autores, y alternativa secundaria por algunos "cuando el beneficio supera al riesgo" (4)(5)(6)(7)(8)(15)(16)(17) .…”

Section: Discussionunclassified

Susceptibilidad antimicrobiana en muestras urogenitales de Ureaplasma urealyticum, el principal agente en infección intramaniótica

et al. 2019

Rev. chil. obstet. ginecol.

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Ureaplasma urealyticum es el agente más frecuentemente aislado en infección intraamniótica. Los macrólidos son los antimicrobianos de primera elección en embarazadas. Se ha descrito el aumento de resistencia, pudiendo limitar las opciones terapéuticas durante la gestación. El propósito del estudio es evaluar susceptibilidad antimicrobiana de Ureaplasma urealyticum aislado en mujeres en edad fértil, que se atienden en Clínica Alemana Temuco, Araucanía, Chile. METODO: Se estudian todas las muestras de orina y flujo vaginal para cultivo de U. urealyticum, de pacientes entre 18 y 40 años, recibidas en el Laboratorio de Microbiología Clínica Alemana Temuco, en período Abril 2013 a Enero 2015. Se procesan las muestras con kit Mycoplasma IST 2 de Biomerieux. En las que resultan positivas, se estudia susceptibilidad a macrólidos, tetraciclinas y quinolonas. RESULTADOS: 426 muestras de orina y flujo vaginal (390 pacientes). 197 pacientes resultaron positivas para U. urealyticum. (50,5%). La susceptibilidad fue 88,4% (174 pctes) a Eritromicina, 87,9% (173 pctes) a Claritromicina y 91,9% (181 pctes) a Azitromicina (NS). 15 de 197 pacientes (7,6%) fueron resistentes a los 3 macrólidos. La susceptibilidad a Quinolonas fue 55,3% a Ciprofloxacino, y 94% a Ofloxacino. El 100% resultó susceptible a Tetraciclinas. CONCLUSIONES: Cerca del 10% de U. urealyticum aislados en nuestra serie son resistentes a macrólidos, contribuyendo a la no erradicación de la infección en tratamientos empíricos. Dentro de ellos, azitromicina aparece con la mayor efectividad. El aumento de resistencia limitará opciones terapéuticas, con gran impacto perinatal en futuro. La vigilancia de susceptibilidad en cada hospital es fundamental para elección terapéutica.

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Prevalence and antimicrobial susceptibility ofUreaplasmaspecies andMycoplasma hominisin Greek female outpatients, 2012–2016

Cited by 9 publications

References 27 publications

Genital mycoplasma infection and spontaneous preterm birth outcome: a prospective cohort study

Genital mycoplasma infection and spontaneous preterm birth outcome: a prospective cohort study

Periprosthetic Joint Infection Caused by Mycoplasma hominis, Diagnosed Using Metagenomic Sequencing

Susceptibilidad antimicrobiana en muestras urogenitales de Ureaplasma urealyticum, el principal agente en infección intramaniótica

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