Prevalence and antimicrobial susceptibility pattern of toxigenic &lt;i&gt;Clostridium difficile&lt;/i&gt; strains isolated in Iran

Mohammadbeigi, Maryam; Delouyi, Zahra Safayi; Mohammadzadeh, Nima; ALA&#039;ALMOHADESIN, Arash; Taheri, Keyvan; Edalati, Elahe; Sedighi, Mansour; Bialvaei, Abed Zahedi

doi:10.3906/sag-1808-11

Cited by 5 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These methods are popular because of their rapid, cost-effective, and easy performance properties. 16 C. difficile infection, especially CDAD has different prevalence worldwide. In our study, C. difficile infection was detected in 4.9% of the patients with diarrhea.…”

Section: Discussionmentioning

confidence: 99%

Clostridium difficile in patients with nosocomial diarrhea, Northwest of Iran

Hematyar

Pirzadeh

Moaddab

et al. 2020

Health Promot Perspect

View full text Add to dashboard Cite

Background: Clostridium difficile is known as a prevalent pathogen leading to infections ranging from mild diarrhea to severe disease and death. The aim of the present study was to evaluate the incidence of C. difficile from inpatients with nosocomial diarrhea hospitalized in different wards in the northwest region of Iran. Methods: In this cross-sectional study, 485 diarrheal stool samples were collected from 384 patients referred from different wards of Imam Reza, Sina and Pediatric hospitals, Tabriz and transferred to the laboratory from 25 March 2015 till 1 March 2018. Immuno-chromatographicassay for detection of toxins A and B of C. difficile was used for identification. Results: Clostridium difficile was isolated from 24 (4.7%) out of 485 samples. Fifteen patients(62.5%) were males and 9 were females (37.5%). Twelve positive patients were from the gastrointestinal ward (50%), 5 patients (20.8%) from surgery ward, 3 patients from infectious disease ward (12.5%), 3 patients from rheumatology ward (12.5%) and 1 patient (4.1%) were collected from neurology ward. 95.3% of diarrhea samples had no signs from toxin A and B. Conclusion: These results indicate most of infected patients were from the gastrointestinaland surgery wards which show a different pattern of infection compared to previous studies.The neurology department had the lowest rate of infection. C. difficile is a health threat afterantibiotic consumption and for health promotion, developing strategies for less antibioticconsumption and preventing these emerging infections is critical. The low rate of this infection shows improvement in knowledge and effect of stewardships in physicians.

show abstract

Section: Discussionmentioning

confidence: 99%

Clostridium difficile in patients with nosocomial diarrhea, Northwest of Iran

Hematyar

Pirzadeh

Moaddab

et al. 2020

Health Promot Perspect

View full text Add to dashboard Cite

show abstract

“…The articles which fulfill eligibility criteria for this systematic review and meta-analysis were conducted. Seven studies from Iran [12,[38][39][40][41][42][43]; two studies in China [44,45]; one study in the United States [46]; one study in European Union (EU) [47]; one study in Poland [48]; one study in Scotland [49]; one study in South Korea [50] and lastly one study in Thailand [51]. All of these studies were done by cross-sectional study design and conducted among hospitalized diarrheal patients (Table 1).…”

Section: Selection and Characteristics Of Included Studiesmentioning

confidence: 99%

Prevalence and antimicrobial resistance pattern of Clostridium difficile among hospitalized diarrheal patients: A systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

Background Clostridium difficile is the leading cause of infectious diarrhea that develops in patients after hospitalization during antibiotic administration. It has also become a big issue in community-acquired diarrhea. The emergence of hypervirulent strains of C. difficile poses a major problem in hospital-associated diarrhea outbreaks and it is difficult to treat. The antimicrobial resistance in C. difficile has worsened due to the inappropriate use of broad-spectrum antibiotics including cephalosporins, clindamycin, tetracycline, and fluoroquinolones together with the emergence of hypervirulent strains. Objective To estimate the pooled prevalence and antimicrobial resistance pattern of C. difficile derived from hospitalized diarrheal patients, a systematic review and meta-analysis was performed. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed to review published studies conducted. We searched bibliographic databases from PubMed, Scopus, Google Scholar, and Cochrane Library for studies on the prevalence and antimicrobial susceptibility testing on C. difficile. The weighted pooled prevalence and resistance for each antimicrobial agent was calculated using a random-effects model. A funnel plot and Egger’s regression test were used to see publication bias. Results A total of 15 studies were included. Ten articles for prevalence study and 5 additional studies for antimicrobial susceptibility testing of C. difficile were included. A total of 1967/7852 (25%) C. difficile were isolated from 10 included studies for prevalence study. The overall weighted pooled proportion (WPP) of C. difficile was 30% (95% CI: 10.0–49.0; p<0.001). The analysis showed substantial heterogeneity among studies (Cochran’s test = 7038.73, I2 = 99.87%; p<0.001). The weighed pooled antimicrobial resistance (WPR) were: vancomycin 3%(95% CI: 1.0–4.0, p<0.001); metronidazole 5%(95% CI: 3.0–7.0, p<0.001); clindamycin 61%(95% CI: 52.0–69.0, p<0.001); moxifloxacin 42%(95% CI: 29–54, p<0.001); tetracycline 35%(95% CI: 22–49, p<0.001); erythromycin 61%(95% CI: 48–75, p<0.001) and ciprofloxacin 64%(95% CI: 48–80; p< 0.001) using the random effect model. Conclusions A higher weighted pooled prevalence of C. difficile was observed. It needs a great deal of attention to decrease the prevailing prevalence. The resistance of C. difficile to metronidazole and vancomycin was low compared to other drugs used to treat C. difficile infection. Periodic antimicrobial resistance monitoring is vital for appropriate therapy of C. difficile infection.

show abstract

Fidaxomicin

Goldenberg

2022

Comprehensive Pharmacology

View full text Add to dashboard Cite

Prevalence and antimicrobial susceptibility pattern of toxigenic <i>Clostridium difficile</i> strains isolated in Iran

Cited by 5 publications

References 55 publications

Clostridium difficile in patients with nosocomial diarrhea, Northwest of Iran

Clostridium difficile in patients with nosocomial diarrhea, Northwest of Iran

Prevalence and antimicrobial resistance pattern of Clostridium difficile among hospitalized diarrheal patients: A systematic review and meta-analysis

Fidaxomicin

Contact Info

Product

Resources

About