Prevalence and Associated Factors of Age-Related Macular Degeneration in a Russian Population: The Ural Eye and Medical Study

Бикбов, М.М.; Зайнуллин, Р.М.; Gilmanshin, Timur R.; Kazakbaeva, Gyulli; Rakhimova, Ellina; Rusakova, Iuliia A; Bolshakova, Natalia I; Safiullina, Kamilla; Yakupova, Dilya F.; Uzianbaeva, Yulia V.; Khalimov, T.A.; Salavatova, Venera F.; Panda‐Jonas, Songhomitra; Arslangareeva, Inga I.; Nuriev, Ildar F.; Bikbova, Guzel; Zaynetdinov, Artur F.; Zinnatullin, A.A.

doi:10.1016/j.ajo.2019.10.004

Cited by 16 publications

(8 citation statements)

References 31 publications

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“…2013; Bikbov et al. 2020b). Based on the OCT images, we considered intraretinal hyperreflective materials, outer retinal atrophy without RPE atrophy, RPE and outer retinal atrophy (RORA) as AMD‐like changes.…”

Section: Methodsmentioning

confidence: 99%

“…As recommended by the Beckman Initiative for Macular Research Classification Committee, we defined AMD using the fundus photographs (Ferris et al 2013;Bikbov et al 2020b). Based on the OCT images, we considered intraretinal hyperreflective materials, outer retinal atrophy without RPE atrophy, RPE and outer retinal atrophy (RORA) as AMD-like changes.…”

Section: Methodsmentioning

confidence: 99%

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Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study

Бикбов

Kazakbaeva

Rakhimova

et al. 2022

Acta Ophthalmologica

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Purpose: To assess the prevalence of reticular pseudodrusen (RPD) and their determinants. Methods: The Population-based Ural Eye and Medical Study conducted in Bashkortostan/Russia included 5899 participants aged 40+ years. Presence of RPDs was assessed on conventional colour fundus photographs, red-free fundus images and optical coherence tomographic images. Results:The study included 4914 (83.3%) individuals (mean age: 58.5 AE 10.5 years; range: 40-94 years). Using two age limits (>55 years and 40+ years) for the definitions of RPD and AMD (age-related macular degeneration), RPD prevalence was 186/4914

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study

Бикбов

Kazakbaeva

Rakhimova

et al. 2022

Acta Ophthalmologica

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“…Особенно пристального и всестороннего внимания специалистов требуют достаточно часто встречающиеся неоваскулярные глазные заболевания, такие как влажная форма возрастной макулярной дегенерации (ВМД), диабетический макулярный отек, ретинопатия недоношенных, неоваскулярная глаукома. Известно, что индукция и процесс ангиогенеза очень часто опосредует интенсивный рост интраокулярных опухолей [1][2][3][4][5].…”

Section: клиническая физиологияunclassified

Features of angiogenesis in eye diseases

Khalimov

2021

Vestn. Ross. univ. družby nar., Ser. Med.

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Based on the analysis of published data, the review provides information on the role and mechanisms of angiogenesis in the development of eye diseases. It has been shown that the developing inflammatory process associated with infections or damage to the organ of vision almost always leads to the appearance of newly formed vessels in the avascular cornea. The progression, in particular, of age-related macular degeneration is associated with the immune-mediated development of angiogenesis processes. A key inducer of angiogenesis is vascular endothelial growth factor (VEGF), whose activity can be enhanced by a number of pro-inflammatory cytokines (tumor necrosis factor alpha, TNF-), growth (fibroblast growth factor, FGF) and transforming factors (transforming growth factor beta, TGF- ). In addition, VEGF overproduction is mediated by an imbalance of pro-angiogenic (angiogenin) and anti-angiogenic (angiostatin, vasostatin, endostatin; tissue inhibitors of matrix metalloproteinases) factors. Antiangiogenic activity based on inhibition of vascular endothelial growth factor (VEGF) has been successfully used in the treatment of a number of eye diseases, such as exudative age-related macular degeneration and diabetic macular edema, the pathogenesis of which is based on the growth of newly formed vessels. The review presents information on the main anti-angiogenic drugs for intravitreal administration, used in ophthalmology.

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“…К социально значимым заболеваниям глаз во всем мире относятся катаракта, глаукома, аномалии рефракции, возрастная макулярная дегенерация (ВМД) и диабетическая ретинопатия (ДР) [1]. В докладе Всемирной организации здравоохранения (ВОЗ) (октябрь 2019 г.)…”

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“…к 2020 г. прогнозировался рост частоты таких глазных заболеваний, как пресбиопия -826 млн чел., ВМД (30-97 лет) -196 млн; ДР -146 млн; нарушения рефракции -124 млн; катаракта -65 млн; глаукома (40-80 лет) -6,9 млн [2]. В то же время, по данным ВОЗ, 80 % всех нарушений зрения можно предотвратить или излечить, проводя раннюю диагностику [1].…”

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Determination of the optical density of macular pigment: clinical value

Бикбов

Usubov

Zaynullina

et al. 2022

Rossijskij oftalʹmologičeskij žurnal

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The density of macular pigment in the central retina is the total concentration of lutein, zeaxanthin and meso-zeaxanthin. Normally, the average value of the optical density of macular pigment can vary significantly as it depends on the person's lifestyle, the total amount of pigment in the body, nutrition, gender, age, as well as concomitant diseases such as diabetes, obesity, arterial hypertension. Differences in the level of optical density of macular pigment between different countries were revealed and it was showed that this parameter drops in cases of retinal pathology, cataract, glaucoma, myopia, macular degeneration, or diabetic macular edema. The level of macular pigment may be considered as a significant diagnostic criterion in many ophthalmic pathologies, so any changes of this parameter require attentive consideration.

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Prevalence and Associated Factors of Age-Related Macular Degeneration in a Russian Population: The Ural Eye and Medical Study

Cited by 16 publications

References 31 publications

Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study

Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study

Features of angiogenesis in eye diseases

Determination of the optical density of macular pigment: clinical value

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