Prevalence and associated factors of clinical manifestations of vitamin a deficiency among preschool children in asgede-tsimbla rural district, north Ethiopia, a community based cross sectional study

Abrha, Tesfalem; Girma, Yonas; Haile, Kebede; Hailu, Mezgebe; Hailemariam, Mengistu

doi:10.1186/s13690-016-0122-3

Cited by 28 publications

(34 citation statements)

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“…High risk of selection bias was observed in eight studies. Measurement bias was observed in three studies [28,32,34]. Bias related to analysis was also observed in three studies [8,27,33] (Supplementary file 1: Table S1).…”

Section: Risk Of Bias and Heterogeneitymentioning

confidence: 84%

“…The national prevalence of child night blindness was 0.8% in 2005 with high rate in the Harari region (1.1%) followed by the Amhara and Benishangul-Gumuz (both 1.0%) [14]. Likewise, about 1.2% of child night blindness was documented in the rural Tigray region in 2014 [32] and the lowest prevalence (0.6%) was reported in Amhara region in 2015 [33] ( Table 3). The overall prevalence of the meta-analysis of 13 studies, according to the Der Simonian-Laird random-effects model, revealed that the pooled prevalence of night blindness among preschool-age children in Ethiopia was 2.8% (95% CI: 1.9%-3.8%) ( Figure 7).…”

Section: Prevalence Of Clinical Vitamin a Deficiency (Xerophthalmia)mentioning

confidence: 95%

“…All 15 studies included in this systematic review and metaanalysis were community-based cross-sectional studies. Seven studies used both clinical and subclinical (biochemical) assessment methods [8,16,[24][25][26][27][28], and six of them used clinical assessment method only [29][30][31][32][33][34], while two studies were subclinical assessment method only [15,35]. Thirteen 3 BioMed Research International studies indicated the prevalence of xerophthalmia through clinical examination.…”

Section: Characteristics Of the Studies A Total Of 4150 Publishedmentioning

confidence: 99%

“…A study conducted in 1991 in Hararge region documented 10.7% prevalence of Bitot's spot [29], while a study conducted in 1993 reported high prevalence of Bitot's spot (26.5%) among preschool children in Oromia region [24], whereas in 1997, it was 0.5% in a study done in the same district of Arsi zone [28]. Similarly, four studies [8,25,31,32] conducted in Tigray region had shown a reduction of the prevalence of Bitot's spot ranging from 3.4% in 1993 [31] to 1.5% in 2014 [28]. Likewise, the prevalence of Bitot's spot in southwest Ethiopia was 2.1% in 1993 [30], while in 1995, it was 0.5% [34].…”

Section: Prevalence Of Clinical Vitamin a Deficiency (Xerophthalmia)mentioning

confidence: 99%

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Prevalence of Vitamin A Deficiency among Preschool Children in Ethiopia: A Systematic Review and Meta‐Analysis

Sahile

Gebremichael

Tezera

et al. 2020

BioMed Research International

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Background. Vitamin A deficiency is a major nutritional concern in lower-income countries. The aim of this systematic review and meta-analysis was to show the magnitude of vitamin A deficiency among preschoolers in Ethiopia. Objective. The present study was aimed at synthesizing qualitatively and quantitatively the existing literature on the prevalence of VAD in preschool children in Ethiopia. Methods. Studies were searched through the search engine of Google Scholar, Hinari, MEDLINE/PubMed, Cochrane Library, and Africa-Wide Information. Searching was made using the keywords/MeSH of vitamin A deficiency, xerophthalmia, night blindness, Bitot’s spot, retinol, children, and Ethiopia. Data were analyzed and compared with the WHO threshold criteria to declare a public health problem. Heterogeneity among studies was assessed using a Cochran Q test and I2 statistics. A random-effects model with 95% confidence interval was used for prevalence estimations. Results. Of the 13 studies included in clinical analysis, 12 of them reported the prevalence of night blindness and/or Bitot’s spot among preschool children in Ethiopia which was above WHO cutoff point for the public health problem 1% and 0.5%, respectively. The prevalence of night blindness significantly decreased from moderate public health problem 4.2% (95% CI: 2.8%-5.7%) in a period from 1990 to 2004 to mild public health problem 0.8% (95% CI: 0.6%-1.0%) in a period from 2005 to 2019. Furthermore, statistically insignificant reduction was observed in the prevalence of Bitot’s spot in a period from 1990 to 2004, 2.2% (95% CI: 1.3%-3.2%) to 1.8% (95% CI: 1.2%-2.3%) in a period from 2005 to 2019. Among 8 studies on subclinical vitamin A deficiency, 7 of them indicated a severe public health problem (>20%). The prevalence of subclinical vitamin A deficiency decreased from 55.7% (95% CI: 39.8%-71.6%) in a period from 1990 to 2004 to 28.3% (95% CI: 9.8%-46.7%) in a period from 2005 to 2019, but not statistically significant. Conclusions. Despite the reduced proportion of night blindness and Bitot’s spot, still both clinical and subclinical vitamin A deficiencies remain a public health problem in Ethiopia requiring strengthen intervention through the newly initiated health extension program.

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Section: Risk Of Bias and Heterogeneitymentioning

confidence: 84%

Section: Prevalence Of Clinical Vitamin a Deficiency (Xerophthalmia)mentioning

confidence: 95%

Section: Characteristics Of the Studies A Total Of 4150 Publishedmentioning

confidence: 99%

Section: Prevalence Of Clinical Vitamin a Deficiency (Xerophthalmia)mentioning

confidence: 99%

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Prevalence of Vitamin A Deficiency among Preschool Children in Ethiopia: A Systematic Review and Meta‐Analysis

Sahile

Gebremichael

Tezera

et al. 2020

BioMed Research International

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“…Open Access Library Journal pre-school children [3]. Vitamin A deficiency remains a widespread public health problem among women and children in the developing world [4], and it increases morbidity and mortality due to increased susceptibility to infection [5].…”

mentioning

confidence: 99%

Model of Long-Term Vitamin A Deficiency in the Mammary Gland of Virgin Rats

Gomez¹,

Varas²,

Giménez³

2017

OALib

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Deficiency in vitamin A is an evil in underdeveloped countries where the minimum recommended intake is not achieved. This may have long-term implications on the health of the population. For this reason, it would be very useful to achieve an animal model where the different implications of this deficiency can be observed. This could lead to the formulation of future nutrition politics. The levels of retinoic acid and intermediary of the vitamin A pathway were studied; The levels of retinoic acid and intermediary of the vitamin A pathway (CRBP-1 and RARα) were studied. There was a decrease in the values of retinoic acid main indicator of deficiency of this vitamin in serum, liver and mammary gland and variation in expression of CRBP-1 and RARα mRNA in mammary gland. This model provides a tool for the study of the metabolism of vitamin A and its effects in different organs and especially in virgin mammary gland, where a deficiency is achieved despite being in a state of latency.

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Quality diets for better health: Integrated orange‐fleshed sweetpotato intervention improved dietary practice in southern Ethiopia

Brouwer,

Bocher,

Low

2023

Crop Science

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Poor diet quality for women and children under 2 years of age is the major public health problem in developing countries claiming lives of millions of children and mothers. Nutrition‐sensitive, climate smart orange‐fleshed sweetpotato (OFSP) [Ipomoea batatas (L.) Lam] intervention has been proved to be an effective approach to ensure enhanced diet quality and reduce the health burden faced by women and children. The objective of this study is to contribute to evidence generation effort by assessing the effectiveness of the introduction of vitamin A‐rich, OFSP cultivars alongside social and behavior change communication strategy and agronomic practice in improving diet quality. Cluster‐randomized control trial design was implemented on cross‐sectional data collected from project beneficiary and control households in 2017 (n = 1451) and 2019 (n = 2065). Quasi‐experimental double difference analysis is used to measure the impact of the intervention on key nutrition outcome indicators. Nutrition‐sensitive climate smart agriculture focused on OFSP cultivars with integrated nutrition behavioral change social communication and agronomic training presented significant potential to improved food security, dietary diversity, and frequency of vitamin A food‐rich intake among the rural population of southern Ethiopia. Thus, it is concluded that enhanced investment in nutrition dense agricultural commodities such as orange fleshed‐sweetpotatoes with appropriate training on both nutrition and agronomic can be effective and cheaper means to address the diet quality problem.

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Prevalence and associated factors of clinical manifestations of vitamin a deficiency among preschool children in asgede-tsimbla rural district, north Ethiopia, a community based cross sectional study

Cited by 28 publications

References 9 publications

Prevalence of Vitamin A Deficiency among Preschool Children in Ethiopia: A Systematic Review and Meta‐Analysis

Prevalence of Vitamin A Deficiency among Preschool Children in Ethiopia: A Systematic Review and Meta‐Analysis

Model of Long-Term Vitamin A Deficiency in the Mammary Gland of Virgin Rats

Quality diets for better health: Integrated orange‐fleshed sweetpotato intervention improved dietary practice in southern Ethiopia

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