Prevalence and associated factors of steroid induced impaired glucose metabolism in obstructive lung diseases, Jimma, and Southwest Ethiopia, Africa

Tadesse, Jarso; Vata, Prabhanjan Kumar; Abebe, Reta Kassa

doi:10.18203/2349-3933.ijam20162511

Cited by 2 publications

(2 citation statements)

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“…This was consistent with the ndings of studies conducted in Korea (14.7%) and Spain (18%) [23,39]. This result was higher than the ndings of the studies done in Britain (10%) and Jimma, (11.11%) [40,41]. This difference might be due to variations in sample size, corticosteroid types used, exposure time, study design, and sociodemographic characteristics.…”

Section: Discussionsupporting

confidence: 87%

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Evaluating Serum Glucose Levels and Lipid Profiles in Adult Asthma Patients Taking Corticosteroid Therapy: A Comparative Cross-Sectional Study at Bahir Dar Public Hospitals, 2023

Bayines,

Fetene,

Deress

et al. 2024

Preprint

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Background: Corticosteroid drugs are widely used to manage asthma worldwide. However, their use can potentially lead to side effects like hyperglycemia, diabetes, and dyslipidemia. Previous studies on steroid drug use have shown conflicting results regarding lipid profiles and glucose abnormalities. Methods: An institutional-based comparative cross-sectional study was conducted among asthmatic patients receiving corticosteroid therapy and control subjects at Bahir Dar public hospitals between July 8 and November 10, 2023. A consecutive sampling method with age and sex-matched was used to recruit 304 study participants. Sociodemographic and clinical data were collected using a semi-structured questionnaire. Five milliliters of fasting venous blood samples were drawn. An independent t-test and logistic regression were used to compare the burden of hyperglycemia and dyslipidemia between the two groups and identify associated factors. Results: Asthmatic patients on corticosteroid therapy had significantly higher mean values of serum glucose and lipid profiles, except for HDL-c, compared to the control group. The prevalence of fasting blood glucose, total cholesterol, triglyceride, LDL-c, and HDL-c abnormalities and dyslipidemia were higher in asthmatic patients on corticosteroid therapy. The prevalence of hyperglycemia and dyslipidemia was 20.39% (95% CI: 14.3-27.7), 45.39% (95% CI: 37.3-53.7), and 4.6% (95% CI: 1.9-9.3), 26.31% (95% CI: 20-34) for asthmatic patients on corticosteroid therapy and the control group, respectively. The study also found that dyslipidemia was associated with overweight, obesity, combined corticosteroid use, and high-dose corticosteroids (AOR=7.28; 95% CI: 1.740-30.530, p=0.007, AOR=5.7; 95% CI: 1.447-18.474, p=0.011, and AOR=7; 95% CI: 2.015-24.610, p=0.015, respectively). Conclusions: Asthmatic patients on corticosteroid therapy had higher mean values of serum glucose and lipid profile parameters, along with a significantly higher prevalence of hyperglycemia and dyslipidemia. Further studies should be conducted on a large scale, with long follow-ups, to investigate the effects of steroid drugs on lipid profiles and glucose abnormalities.

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Section: Discussionsupporting

confidence: 87%

“…This difference might be due to variations in sample size, corticosteroid dose, and duration of treatment [41]. The study also showed that the blood glucose of the study participants was positively correlated with total cholesterol, triglyceride, and LDL, and negatively correlated with HDL cholesterol.…”

Section: Discussionmentioning

confidence: 87%

Evaluating Serum Glucose Levels and Lipid Profiles in Adult Asthma Patients Taking Corticosteroid Therapy: A Comparative Cross-Sectional Study at Bahir Dar Public Hospitals, 2023

Bayines,

Fetene,

Deress

et al. 2024

Preprint

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Chronic obstructive pulmonary disease in East Africa: a systematic review and meta-analysis

Mebrahtom,

Hailay,

Mariye

et al. 2024

International Health

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Chronic obstructive pulmonary disease (COPD) is a common lung disease that causes restricted airflow and breathing problems. Globally, COPD is the third leading cause of death and low- and middle-income countries account for the majority of these deaths. There is limited information on COPD's prevalence in East Africa. Thus the purpose of this systematic review and meta-analysis is to estimate the pooled prevalence of COPD in East Africa.A computerized systematic search using multiple databases was performed in search of relevant English articles from the inception of the databases to August 2023. All the authors independently extracted the data. R and RStudio software were used for statistical analysis. Forest plots and tables were used to represent the data. The statistical heterogeneity was evaluated using I2 statistics. There was heterogeneity between the included articles. Therefore, a meta-analysis of random effects models was used to estimate the overall pooled prevalence of COPD in East Africa. A funnel plot test was used to examine possible publication bias.The database search produced 512 papers. After checking for inclusion and exclusion criteria, 43 full-text observational studies with 68 553 total participants were found suitable for the review. The overall pooled prevalence of COPD in East Africa was 13.322%. The subgroup analysis found the COPD pooled prevalence in the different countries was 18.994%, 7%, 15.745%, 9.032%, 15.026% and 11.266% in Ethiopia, Uganda, Tanzania, Malawi, Sudan, and Kenya, respectively. Additionally, the subgroup analysis of COPD by study setting among community-based studies was 12.132% and 13.575% for hospital-based studies.According to the study's findings, approximately one of every seven individuals in East Africa has COPD, indicating a notably high prevalence of the disease. Thus governments and other stakeholders working on non-communicable disease control should place an emphasis on preventive measures to minimize the burden of COPD.

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Prevalence and associated factors of steroid induced impaired glucose metabolism in obstructive lung diseases, Jimma, and Southwest Ethiopia, Africa

Cited by 2 publications

References 4 publications

Evaluating Serum Glucose Levels and Lipid Profiles in Adult Asthma Patients Taking Corticosteroid Therapy: A Comparative Cross-Sectional Study at Bahir Dar Public Hospitals, 2023

Evaluating Serum Glucose Levels and Lipid Profiles in Adult Asthma Patients Taking Corticosteroid Therapy: A Comparative Cross-Sectional Study at Bahir Dar Public Hospitals, 2023

Chronic obstructive pulmonary disease in East Africa: a systematic review and meta-analysis

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