Prevalence and associated factors of psychological distress in tuberculosis patients in Northeast China: a cross-sectional study

Chen, Xu; Wu, Ruiheng; Xu, Jia; Wang, Jiawei; Gao, M.; Chen, Yunting; Pan, Yuanping; Ji, Haoqiang; Duan, Yuxin; Sun, Meng; Du, Liang; Zhou, Ling

doi:10.1186/s12879-021-06284-4

Cited by 17 publications

(14 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, in Russia, an association with prisons and poverty has persisted, despite TB affecting all sectors of society [42]. Stigma was most acutely felt in China, and a recent study described psychological distress in nearly two-thirds of TB patients, associated with a high experienced stigma [43]. In our study, some patients did not even disclose their diagnosis to close family.…”

Section: Discussioncontrasting

confidence: 55%

Living with tuberculosis: a qualitative study of patients’ experiences with disease and treatment

et al. 2022

View full text Add to dashboard Cite

Background Although tuberculosis (TB) is a curable disease, treatment is complex and prolonged, requiring considerable commitment from patients. This study aimed to understand the common perspectives of TB patients across Brazil, Russia, India, China, and South Africa throughout their disease journey, including the emotional, psychological, and practical challenges that patients and their families face. Methods This qualitative market research study was conducted between July 2020 and February 2021. Eight TB patients from each country (n = 40) completed health questionnaires, video/telephone interviews, and diaries regarding their experiences of TB. Additionally, 52 household members were interviewed. Patients at different stages of their TB treatment journey, from a range of socioeconomic groups, with or without TB risk factors were sought. Anonymized data underwent triangulation and thematic analysis by iterative coding of statements. Results The sample included 23 men and 17 women aged 13–60 years old, with risk factors for TB reported by 23/40 patients. Although patients were from different countries and cultural backgrounds, experiencing diverse health system contexts, five themes emerged as common across the sample. 1) Economic hardship from loss of income and medical/travel expenses. 2) Widespread stigma, delaying presentation and deeply affecting patients’ emotional wellbeing. 3) TB and HIV co-infection was particularly challenging, but increased TB awareness and accelerated diagnosis. 4) Disruption to family life strained relationships and increased patients’ feelings of isolation and loneliness. 5) The COVID-19 pandemic made it easier for TB patients to keep their condition private, but disrupted access to services. Conclusions Despite disparate cultural, socio-economic, and systemic contexts across countries, TB patients experience common challenges. A robust examination of the needs of individual patients and their families is required to improve the patient experience, encourage adherence, and promote cure, given the limitations of current treatment.

show abstract

Section: Discussioncontrasting

confidence: 55%

Living with tuberculosis: a qualitative study of patients’ experiences with disease and treatment

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Inclusion criteria for the study were as follows: (1) confirmed and highly suspected TB patients who have been diagnosed in accordance with national TB program guidelines ( 23 , 24 ); (2) those who could complete the questionnaire with their communication and cognitive skills; and (3) those who voluntarily participated in the study. Patients with severe somatic disorders, including but not limited to tumors, critical infections, immune diseases; or confirmed psychiatry disorders; or those took on special drugs, such as psychotropic or immune-altering medications, were excluded.…”

Section: Methodsmentioning

confidence: 99%

Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: A cross-sectional study

Liu

Bai²,

Ren³

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundDepression and anxiety are major psychological issues among patients with tuberculosis (TB) owing to chronic and complex treatments, have been reported to be closely correlated with immune and inflammation. However, the association of peripheral immune-inflammatory characteristics with depression/anxiety symptoms in in-patients with TB has rarely been reported.MethodsA cross-sectional study of 338 in-patients with TB from 3 hospitals in China were enrolled to investigate their depression and anxiety status by using the nine-item Patient Health Questionnaire (PHQ-9) and seven-item Generalized Anxiety Disorder Scale (GAD-7). Participants were divided into groups based on their PHQ-9 and GAD-7 scores, and differences in demography and immune-inflammatory characteristics were studied. Logistic analysis was performed to explore factors related to depression and anxiety symptoms.ResultsDepression and anxiety prevalence among patients with TB was 47.9 and 42.6%, respectively. Furthermore, 38.5% of patients reported a comorbidity of depression and anxiety symptoms. The counts of CD3, CD4, CD8, and lymphocytes decreased, whereas those of neutrophils, platelets, and peripheral blood cells and their derived indices increased among TB patients with depression or anxiety in comparison with those without symptoms (p < 0.05). In addition, increasing age, lower income (monthly income ≤ 3,000 yuan), divorced or widowed, drug resistance, and higher systemic immune inflammation index (SII) were significantly associated with depression or anxiety symptoms (p < 0.05).ConclusionApproximately half of the patients with TB suffered from depression or/and anxiety symptoms. Patients with depression or anxiety present worse cell immune status and stronger inflammatory responses compared to those without symptoms. We emphasized the importance of paying attention to the dysfunction of immune-inflammation process of TB patients with depression or anxiety symptoms. Especially, SII has a potential application value in guiding the evaluation of TB-related depression or anxiety owing to its easily accessibility and being economical.

show abstract

“…The inclusion criteria were as follows: (1) Confirmed or highly suspected TB patients who have been diagnosed based on the guidelines of the national TB program ( 17 , 22 ); (2) Patients who could complete the questionnaire with their communication and cognitive skills; and (3) Patients who voluntarily participated in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Another study showed that more than half of the TB patients perceived higher stress, which increased the risk of emotional distress ( 16 ). Previous studies have shown that the presence of at least one chronic disease, such as diabetes, in TB patients is closely associated with psychological distress ( 17 ). The incidence of TB is accompanied by a decrease in appetite, nutrient malabsorption, and metabolism disturbance, leading to wasting and undernutrition status ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Sleep quality and its associated factors among patients with tuberculosis: A cross-sectional study

Liu

Lan

Bai

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundTuberculosis (TB) patients commonly suffer from sleep issues owing to various adverse drug reactions (ADRs), disease symptoms, and the contagious nature of their disease. These sleep issues negatively affect the treatment outcome and quality of life. However, the prevalence of sleep disturbance and its associated factors among TB patients have rarely been reported.MethodsA total of 497 inpatients with TB from three hospitals in China were enrolled in this cross-sectional study to investigate their sleep quality using the Pittsburgh sleep quality index (PSQI). Clinical data, including demographic information, TB-related stigma, perceived stress, and nutrition- and immunity-related indicators, were also collected to explore the factors associated with sleep disturbance among the recruited patients.ResultsApproximately 70% of the recruited patients reported a sleep disturbance to varying degrees, presenting poorer global and subjective sleep qualities, longer sleep latency, shorter sleep duration, lower sleep efficiency, more frequent sleep disturbances, greater use of sleeping medication, and more severe daytime dysfunction. Furthermore, the body mass index (BMI), hemoglobin levels, albumin levels, and T lymphocyte count of the patients in the poor sleep quality group were significantly lower than those in the good sleep quality group (p < 0.05). Increasing age, higher income, drug resistance, higher stigma or stress perception, lower albumin levels, and lower CD4 levels were significantly associated with sleep disturbance among TB patients (p < 0.05).ConclusionThree-quarters of the participants were found to suffer from a probable sleep disturbance. And sleep problems are linked to biological traits that interact with psychological, cultural, and social factors in complex ways. It is therefore important to pay attention to the sleep quality of TB patients, especially those with the identified risk factors. Besides, taking care of these risk factors may prove to be an effective sleep management strategy.

show abstract

Prevalence and associated factors of psychological distress in tuberculosis patients in Northeast China: a cross-sectional study

Cited by 17 publications

References 47 publications

Living with tuberculosis: a qualitative study of patients’ experiences with disease and treatment

Living with tuberculosis: a qualitative study of patients’ experiences with disease and treatment

Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: A cross-sectional study

Sleep quality and its associated factors among patients with tuberculosis: A cross-sectional study

Contact Info

Product

Resources

About