Prevalence and associations of diabetic retinopathy in a large cohort of prediabetic subjects: The Gutenberg Health Study

Lamparter, Julia; Raum, Philipp; Pfeiffer, Norbert; Pető, Tünde; Höhn, René; Elflein, Heike M.; Wild, Philipp S.; Schulz, Andreas; Schneider, Astrid; Mirshahi, Alireza

doi:10.1016/j.jdiacomp.2014.02.008

Cited by 71 publications

(53 citation statements)

References 41 publications

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“…Most studies in the world literature concern retinopathy that is the most serious ocular complication of diabetes and the leading cause of vision impairment and blindness in diabetic patients. Its frequency in people with IFG and/or IGT is estimated in the previous analysis at 7.9-12% [7][8][9]. In our study, the proportion of patients with retinopathy was 8.33%, which is comparable to the results of other researchers.…”

Section: Discussionsupporting

confidence: 90%

The evaluation of ocular changes in prediabetic individuals

Sokołowska-Oracz

Piątkiewicz

2017

Clinical Diabetology

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Section: Discussionsupporting

confidence: 90%

The evaluation of ocular changes in prediabetic individuals

Sokołowska-Oracz

Piątkiewicz

2017

Clinical Diabetology

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“…Nevertheless, as this prophylactic therapy is not recommended according to the Guidelines of the German Diabetes Association [38], we suppose that the number of prediabetic persons treated with off-label oral antidiabetic drugs was rather low. The results on the prevalence of DR in prediabetes have been published previously [39]. …”

Section: Discussionmentioning

confidence: 99%

Prevalence and Cardiovascular Associations of Diabetic Retinopathy and Maculopathy: Results from the Gutenberg Health Study

et al. 2015

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ObjectiveDiabetic retinopathy (DR) is the leading cause of blindness in people of working age. The purpose of this paper is to report the prevalence and cardiovascular associations of diabetic retinopathy and maculopathy (DMac) in Germany.Research Design and MethodsThe Gutenberg Health Study (GHS) is a population-based study with 15,010 participants aged between 35 at 74 years from the city of Mainz and the district of Mainz-Bingen. We determined the weighted prevalence of DR and DMac by assessing fundus photographs of persons with diabetes from the GHS data base. Diabetes was defined as HbA1c ≥ 6.5%, known diagnosis diabetes mellitus or known diabetes medication. Furthermore, we analysed the association between DR and cardiovascular risk factors and diseases.ResultsOverall, 7.5% (1,124/15,010) of the GHS cohort had diabetes. Of these, 27.7% were unaware of their disease and thus were newly diagnosed by their participation in the GHS. The prevalence of DR and DMac was 21.7% and 2.3%, respectively among patients with diabetes. Vision-threatening disease was present in 5% of the diabetic cohort. In the multivariable analysis DR (all types) was associated with age (Odds Ratio [95% confidence interval]: 0.97 [0.955–0.992]; p = 0.006) arterial hypertension (1.90 [1.190–3.044]; p = 0.0072) and vision-threatening DR with obesity (3.29 [1.504–7.206]; p = 0.0029). DR (all stages) and vision-threatening DR were associated with duration of diabetes (1.09 [1.068–1.114]; p<0.0001 and 1.18 [1.137–1.222]; p<0.0001, respectively).ConclusionsOur calculations suggest that more than a quarter-million persons have vision-threatening diabetic retinal disease in Germany. Prevalence of DR was lower in the GHS compared to East-Asian studies. Associations were found with age, arterial hypertension, obesity, and duration of diabetes mellitus.

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“…In the largest European study evaluating the prevalence of RP in a prediabetic population of Caucasian origin, the Gutenberg Health Study, the prevalence of any RP in a prediabetic subgroup, defined by haemoglobin A1c levels between 5.7% and 6.4%, was 8.1%, but no association with obesity was reported 17. Studies examining RP prevalence vary largely by inclusion criteria such as ethnicity, age and comorbidities, and characterise the group studied consisting predominantly of Caucasian, predominantly female (two-thirds), young (mean age 41 years) individuals with severe obesity (mean BMI 50 kg/m 2 ) as uncommon.…”

Section: Discussionmentioning

confidence: 96%