Prevalence and causes of congenital microcephaly in the absence of a Zika virus outbreak in southern Brazil

Herber, Silvani; Silva, André A.; Sanseverino, Maria Teresa Vieira; Friedrich, Luciana; Ranieri, Tani Schilling; Favreto, Cátia; Fraga, Lucas Rosa; Terra, Anna Pires; Schwartz, Ida Vanessa Döederlein; Schüler‐Faccini, Lavínia

doi:10.1016/j.jped.2018.05.013

Cited by 17 publications

(20 citation statements)

References 14 publications

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“…Among the agents belonging to the TORCH group, a predominance in the diagnosis of congenital syphilis associated with congenital microcephaly was observed, specifically in the studies by Ribeiro et al 25 and Herber et al 28 . This information confirms the data from the latest Epidemiological Bulletin of Syphilis of the Ministry of Health (2020) that in Brazil, in general, in the last 10 years and especially from 2010, there has been a progressive increase in the incidence rate of congenital syphilis: in 2008, the rate was 2.0 cases/1,000 live births, and in 2018, they were more than four times higher, reaching 9.0 cases/1,000 live births, decreasing to 8.2 cases per 1,000 live births in 2019.…”

Section: Discussionmentioning

confidence: 95%

“…Although numerous, almost all publications in databases were unable to answer the target question of this review. For the primary endpoint of congenital microcephaly due to an infectious cause, it was possible to extract data in only 10 articles [19][20][21][22][23][24][25][26][27][28] . All selected studies were published after the year 2015, with data obtained in the period between years 2015 and 2017, during the ZIKV epidemic in the country.…”

Section: Discussionmentioning

confidence: 99%

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Microcephaly caused by or associated with congenital infections in the last 20 years in Brazil: a systematic review

Quintans

Bueno

Cardoso

2022

Rev. Inst. Med. trop. S. Paulo

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This systematic review aimed to identify the pathogens causing or associated with congenital microcephaly in Brazil in the last 20 years due to the lack of official information by the Health Authorities and, as a consequence the uncertainty on the real infectious etiology of congenital microcephaly. A review protocol was prepared according to the PRISMA recommendation, using the PubMed, SciELO and LILACS databases to search for references presenting original data on microcephaly caused by or associated with congenital infectious in Brazil, using the descriptors "MICROCEPHALY AND INFECTION". The search ended on 30/Jun/2020. All selected titles were read in full and analyzed independently by the three reviewers. After searching the databases, 2,389 articles were selected for title review. Of these, 109 were excluded due to duplicates and 2,236 according to the criteria defined in the review. Only 44 met the eligibility criteria and were therefore read in full. Data extraction was performed on 10 articles, all published after 2015. Seven studies were literature reviews or case series, only two were case-control, and one was a cross-sectional study. As the studies focused on the period of the ZIKV epidemic in Brazil, the cases of congenital microcephaly between 2015 and 2017 were attributed to maternal infection by this virus when it was not possible to prove the presence of other etiological agents. Among the TORCH agents, a predominance of syphilis was observed. The analyzed studies did not add consistent information about the infectious causes or association of microcephaly in Brazil outside the period of ZIKV epidemic, revealing the need for more studies on the subject.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Microcephaly caused by or associated with congenital infections in the last 20 years in Brazil: a systematic review

Quintans

Bueno

Cardoso

2022

Rev. Inst. Med. trop. S. Paulo

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“…• 3 Herber et al [2019] realizaram um estudo transversal onde foram incluídas todas as notificações de microcefalia congênita no estado do Rio Grande do Sul no período de 1º de dezembro de 2015 a 31 de dezembro de 2016. Dos 153.744 nascidos vivos registrados no período do estudo, 148 casos foram notificados, mas apenas 58 foram confirmados para microcefalia.…”

Section: Trabalhos Relacionadosunclassified

“…Alguns autores afirmam que o baixo peso ao nascer e a prematuridade são apontados como desfechos adversos mais frequentes da infecção pelo ZKV [Ribeiro et al 2018]. Outros entendem que apesar de crianças com microcefalia apresentarem maior probabilidade de ter baixo peso ao nascer, a frequência de prematuridade não é alta [Herber et al 2019]. A regra ao combinar perímetro cefálico normal e peso inferir a 3035 está de acordo com a literatura, já que é sabido que crianças com microcefalia devido ao ZKV, mesmo quando nascem com peso e comprimento normais, apresentam agravamento de seu estado nutricional, apresentando baixo peso duas vezes maior em relação às crianças não infectadas com a mesma idade [Brasil et al 2017].…”

Section: Análise Das Regras De Classificação Obtidasunclassified

Classification of Newborns with Congenital Syndrome Associated with Zika Virus Infection Using Machine Learning

Assis¹,

Zárate²,

Nobre³

2021

Anais Do IX Symposium on Knowledge Discovery, Mining and Learning (KDMiLe 2021)

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Due to evidence that Zika virus (ZIKV) infection during pregnancy caused congenital brain anomalies, including microcephaly, in 2016 the WHO declared this disease a worldwide public health problem. The objective of this work is to identify the most important characteristics for the diagnosis of children with congenital syndrome due to ZIKV virus infection. We applied machine learning algorithms to RESP-Microcephaly, a database from the Brazilian Ministry of Health that records suspected cases of congenital abnormalities. At the end of the process, the most relevant characteristics were: weight, age of the pregnant woman, length, head circumference and region where the mother lives. This information is very significant as it is in agreement with the literature that associates these attributes with critical factors for the occurrence of congenital infection.

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“…Zika incidence has decreased in equatorial Brazil, [40][41][42] yet the impacts of the pandemic persist inequitably across the region. A recent analysis demonstrated that women from more impoverished communities experienced a higher burden of infants with CZS.…”

Section: %mentioning

confidence: 99%

Women’s Health Perceptions and Beliefs Related to Zika Virus Exposure during the 2016 Outbreak in Northern Brazil

Anderson

Ernst

Martins³

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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During the 2016 Zika pandemic in Brazil, women's perceptions of infection risk, ability to adhere to Zika prevention strategies, or access to services following exposure were not emphasized in the public health response. Women in Fortaleza, Brazil, responded to a questionnaire on social factors related to perceived Zika risk and access to health care in June 2016. Data were coded using prespecified categories, and response frequency was reported. Of 37 respondents, most reported a lack of public services to support mosquito control (n = 19) or delayed access to reproductive health care (n = 14). Only 22% described specific maternal risks or fetal outcomes as a consequence of Zika infection. Respondents indicated an overall disconnect between public health efforts and women's perceptions of their reproductive control, including limited support concerning microcephaly in infants. Interventions targeting Zika may require a greater emphasis on strengthening health systems and infrastructure to realistically prevent transmission.

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Prevalence and causes of congenital microcephaly in the absence of a Zika virus outbreak in southern Brazil

Cited by 17 publications

References 14 publications

Microcephaly caused by or associated with congenital infections in the last 20 years in Brazil: a systematic review

Microcephaly caused by or associated with congenital infections in the last 20 years in Brazil: a systematic review

Classification of Newborns with Congenital Syndrome Associated with Zika Virus Infection Using Machine Learning

Women’s Health Perceptions and Beliefs Related to Zika Virus Exposure during the 2016 Outbreak in Northern Brazil

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