Prevalence and Causes of Hyperuricemia in Children

Kumar, Jitendra; Gupta, Aarzoo; Dev, Kapeel; Kumar, Sandeep; Kataria, Deepak; Gul, Ambresha; Abbas, Mohammed Talat; Jamil, Amna; Shahid, Simra; Memon, Sidra

doi:10.7759/cureus.15307

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Considering that changes in uric acid levels occur gradually during development, it is natural that the amount of uric acid depends on age, as seen in our study. In line with this finding of ours, Kumar and colleagues 2021 showed that hyperuricemia was more common in older children (58).…”

Section: Discussionsupporting

confidence: 84%

Potentials of Hyperuricemia and Insulin Levels in Predicting Hypertension in Obese Children: A Cross-sectional Study

Dalili,

Hassanzadeh Rad,

Salkhori

et al. 2023

J Compr Ped

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Background: Recent studies in humans show that increased uric acid predicts hyperinsulinemia and obesity. Objectives: Our study aimed to investigate whether hyperuricemia and insulin levels predict hypertension in obese children. Methods: This analytical cross-sectional study was conducted on the records of 161 obese children aged 5 to 15 years old based on the defined inclusion criteria. Children's blood pressure, height, weight, FBS (fasting blood sugar), HDL (high-density lipoprotein), LDL (low-density lipoprotein), TG (triglyceride), HbA1c (hemoglobin A1c), urine albumin, creatinine, insulin levels, and uric acid were measured. Data were analyzed by SPSS software. The significance level was considered P < 0.05. Results: According to the data obtained from this study, the mean of SBP (systolic blood pressure) and DBP (diastolic blood pressure) in obese children with hyperuricemia was higher than in obese children without hyperuricemia. The average insulin in obese children and hypertension was higher than in obese children without hypertension, especially in males and the age group of 5 - 10 years. The levels of cholesterol and LDL in hypertensive males were higher than in those with hyperuricemia. HDL was higher in children without hyperuricemia than in children with hyperuricemia. The strongest predictors of uric acid were age (P < 0.001, B = 0.183), HbA1c (P = 0.014, B = 0.255), and cholesterol (P = 0.03, B = -0.007), respectively. Conclusions: Based on this study, there is a relationship between uric acid levels and parameters such as obesity and blood pressure, and the findings showed that increased uric acid predicts hyperinsulinemia and obesity. Therefore, this study indicates that physicians and healthcare workers should consider the level and state of uric acid.

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Section: Discussionsupporting

confidence: 84%

Potentials of Hyperuricemia and Insulin Levels in Predicting Hypertension in Obese Children: A Cross-sectional Study

Dalili,

Hassanzadeh Rad,

Salkhori

et al. 2023

J Compr Ped

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“…Other studies showed variable results, in a study in Korea 18 the prevalence was ( 9.4%). However, higher results were obtained in the Pakistan study (26.02%) 19 , and in U.S 20 study (30.2%). These differences among studies can be explained as hyperuricemia is the result of combinations of many factors including, genetic, variable lifestyles, and environmental risk factors, in addition to different age group samples among each study.…”

mentioning

confidence: 60%

Hyperuricemia And Its Relation With Obesity Among Children In Anbar Province

Hussein Ali Hussein,

Al‐Dulaimy,

Al-Dulaimy

2024

ijmsci

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Background; The prevalence of pediatric hyperuricemia is increasing worldwide. No other similar study was done in Anbar province previously. Objective: This study was designed to show the prevalence of hyperuricemia among children from 6 to 16 years old in Ramadi teaching hospital for maternity and childhood, Anbar province, Iraq. Studying the relation of hyperuricemia with childhood obesity, in addition to its relation with gender, residency, and economic status of their families. Material and Methods: Across sectional study was done for 6 months from the first of January 2021 to the end of June 2021, to determine the expected prevalence of hyperuricemia among a randomized sample of children of ages from 6-16 years with either gender. Weight and height were measured for all cases, a body mass index was calculated for each child for estimation of obesity. For all studied cases, other data was collected for socioeconomic status and residency. All cases were sent for serological calculation of uric acid levels. Results: The total number of studied children was 520, the overall prevalence of hyperuricemia among these cases was (11.3%). The overweight's and obese children had a higher prevalence of hyperuricemia (29.3 %) compared with only (3.3%) among those who were not. Girls had more prevalence than boys with female to male ratio (2.2:1). Most of the cases were from middle-economic status families with a non-significant relation when compared with control, while it was more and significant among urban area residence. Conclusions: A higher prevalence of hyperuricemia was found among obese children in Anbar province, and this requires a specific educational program given to the families in explaining the risk and how to deal with obesity.

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“…High FPG was defined at ≥ 100 mg/dL 21 and elevated ALT at > 40 IU/L. Hyperuricemia was defined as ≥ 6.0 mg/dL in subjects aged 12 years and ≥ 7.5 mg/dL in subjects aged 13–18 years based on reference values from the Mayo Clinic Laboratories 22 .…”

Section: Methodsmentioning

confidence: 99%

Associations of overweight and obesity with cardiometabolic risk factor clusters among Korean adolescents

Huh,

Park

2024

Sci Rep

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This study investigated the association between overweight, obesity, and cardiometabolic risk factor clusters in Korean adolescents. We included 2182 participants (1161 boys and 1021 girls) aged 12–18 years from the Korea National Health and Nutrition Examination Survey (2016–2021). Cardiometabolic risk factors include hypertension, high low-density lipoprotein cholesterol (LDL-C) level, low high-density lipoprotein cholesterol (HDL-C) level, hypertriglyceridemia, high fasting plasma glucose level, elevated alanine aminotransferase level, and hyperuricemia. The average age was 15.1 ± 0.1 years in both boys and girls. The proportion of subjects with ≥ 1, ≥ 2, and ≥ 3 cardiometabolic risk factors was 76.5%, 49.8%, and 22.7% in obese adolescents, and 60.5%, 24.0%, and 9.1%, in overweight adolescents, respectively. Compared to adolescents with underweight/normal weight, the odds ratios (ORs) and 95% confidence intervals for the clustering of cardiometabolic risk factors were at 2.76 (1.74–4.38) for ≥ 1; 3.75 (2.11–6.66) for ≥ 2; and 4.75 (1.70–13.25) for ≥ 3 factors in obese adolescents and 1.88 (1.26–2.81) for ≥ 1 factor in overweight adolescents. Overweight and obese adolescents exhibited high cardiometabolic risk clustering. Prevention and management of overweight/obesity in Korean adolescents are emerging to mitigate health risk associated with this condition.

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Prevalence and Causes of Hyperuricemia in Children

Cited by 5 publications

References 21 publications

Potentials of Hyperuricemia and Insulin Levels in Predicting Hypertension in Obese Children: A Cross-sectional Study

Potentials of Hyperuricemia and Insulin Levels in Predicting Hypertension in Obese Children: A Cross-sectional Study

Hyperuricemia And Its Relation With Obesity Among Children In Anbar Province

Associations of overweight and obesity with cardiometabolic risk factor clusters among Korean adolescents

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