Prevalence and causes of vision impairment and blindness in the Russian ural eye and medical study

Бикбов, М.М.; Kazakbaeva, Gyulli; Зайнуллин, Р.М.; Gilmanshin, Timur R.; Nuriev, Ildar F.; Zaynetdinov, Artur F.; Yakupova, Dilya F.; Uzianbaeva, Yulia V.; Panda‐Jonas, Songhomitra; Mukhamadieva, Svetlana R.; Khikmatullin, Renat I.; Aminev, Said K.; Arslangareeva, Inga I.

doi:10.1038/s41598-020-69439-4

Cited by 10 publications

(20 citation statements)

References 26 publications

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“…In the UEMS population, which included participants with substantially younger ages, myopic maculopathy was the second most common factor associated with irreversible blindness (2 of 8 individuals [25.0%] with irreversible blindness, or 2 of 5893 individuals [0.03%] in the total study population) and the second most common factor associated with irreversible moderate to severe VI (11 of 73 individuals [15.1%] with irreversible moderate to severe VI, or 11 of 5893 individuals [0.2%] in the total study population). 23 The prevalence of myopic maculopathy as a factor associated with blindness (0.3% in our study vs 0.03% in the UEMS) and moderate to severe VI (1.1% in our study vs 0.2% in the UEMS) was thus higher in our older population compared with the younger population of the UEMS. Even if one assumes a further age-related increase in the prevalence of myopic maculopathy, the 5- to 10-fold higher prevalence of myopic maculopathy as a factor associated with blindness or moderate to severe VI in our older study population compared with the middle-aged population of the UEMS suggests that, in the UEMS and UVOS study regions, the prevalence of myopic maculopathy as a factor associated with moderate to severe VI or blindness (in the middle-aged population) may not have substantially increased compared with previous periods.…”

Section: Discussioncontrasting

confidence: 42%

“…Factors associated with moderate to severe VI and blindness were older age, lower MMSE score, lower dynamometric hand grip force, lower prothrombin index, lower prevalence of previous cataract surgery, and more substantial cylindrical refractive error ( Table 3 ). Although the associations with older age have also been reported in previous studies, 4 , 23 , 25 , 26 , 27 , 28 , 29 the association between a higher prevalence of moderate to severe VI and blindness and lower cognitive function (as measured by MMSE score) is of interest because another study 31 found an association between the prevalence of Alzheimer disease and hearing loss. This finding suggests that cataract surgery (and the provision of best-correcting glasses), in particular, may be a means of reducing the risk of cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 77%

“… 18 , 19 The marked difference in prevalence was mainly because of the substantial difference in participant age. Among participants in the oldest age category in the UEMS (202 participants ≥80 years; mean [SD] age, 83.0 [2.9] years), the prevalence of moderate to severe VI was 19.2% (95% CI, 10.3%-28.2%) among men and 27.6% (95% CI, 19.6%-35.7%) among women 23 ; this finding was substantially lower than the prevalence of 48.9% (95% CI, 46.0%-51.8%) found in the older population in the present study (mean [SD] age, 88.2 [2.8] years). In the ALIENOR study 24 of individuals 75 years and older, which used the oldest age inclusion criterion among ophthalmologically related population-based studies to date, the prevalence of blindness and moderate to severe VI has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

“…We assessed the prevalence of blindness, moderate to severe VI, and mild VI (reported as means with 95% CIs) using SPSS for Windows, version 25.0 (SPSS Institute), and we performed a binary regression analysis of the association between the prevalence of moderate to severe VI or blindness and other demographic, clinical, and ocular factors. 23 This analysis was followed by a multivariable regression analysis, with the prevalence of blindness or moderate to severe VI as the dependent variable and all factors that were significantly associated with prevalence as independent variables in the univariate analyses. We then removed, in a step-by-step manner, those factors from the list of independent variables that had collinearity with other factors and that were no longer significantly associated with the prevalence of moderate to severe VI or blindness.…”

Section: Methodsmentioning

confidence: 99%

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Prevalence Factors Associated With Vision Impairment and Blindness Among Individuals 85 Years and Older in Russia

et al. 2021

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IMPORTANCE Visual performance is important for quality of life. However, vision impairment among adults 85 years and older has not been intensively examined.OBJECTIVE To assess the prevalence of mild vision impairment (VI), moderate to severe vision impairment, and blindness and the factors associated with these conditions among a population 85 years and older. DESIGN, SETTING, AND PARTICIPANTSThe Ural Very Old Study was a population-based cohort study conducted in rural and urban areas in Bashkortostan, Russia from 2017 to 2020. Among 1882 eligible individuals 85 years and older, 1526 participants (81.1%) were enrolled. EXPOSURES Ophthalmologic, physical, and mental examinations. MAIN OUTCOMES AND MEASURES Prevalence of vision impairment and blindness based on best-corrected visual acuity (BCVA; measured using modified Early Treatment of Diabetic Retinopathy Study charts) in the better eye or both eyes. Mild vision impairment was defined as BCVA worse than 6/12 to 6/18, and moderate to severe VI was defined as BCVA worse than 6/18 but equal to or better than 3/60. Blindness was defined as BCVA worse than 3/60. RESULTS Among 1526 participants, 1149 individuals (75.3%; 846 women [73.6%]; mean [SD] age, 88.2 [2.8 years]) had available BCVA measurements and were included in the present analysis. Mild vision impairment was present in 114 individuals (9.9%; 95% CI, 8.2%-11.7%), moderate to severe VI in 562 individuals (48.9%; 95% CI, 46.0%-51.8%), and blindness in 68 individuals (5.9%; 95% CI, 4.6%-7.3%). Factors associated with moderate to severe VI were cataracts (324 individuals [57.7% of those with moderate to severe VI and 28.2% of total population; 95% CI, 25.6%-30.8%]), secondary cataracts (4 individuals [0.7% of those with moderate to severe VI and 0.3% of total population; 95% CI, 0%-0.7%]), age-related macular degeneration (78 individuals [13.9% of those with moderate to severe VI and 6.8% of total population; 95% CI, 5.3%-8.3%]), glaucoma (45 individuals [8.0% of those with moderate to severe VI and 3.9% of total population; 95% CI, 2.8%-5.0%]), corneal opacifications (26 individuals [4.6% of those with moderate to severe VI and 2.3% of total population; 95% CI, 1.4%-3.1%]), myopic maculopathy (13 individuals [2.3% of those with moderate to severe VI and 1.1% of total population; 95% CI, 0.5%-1.7%]), and nonglaucomatous optic nerve damage (4 individuals [0.7% of those with moderate to severe VI and 0.3% of total population; 95% CI, 0%-0.7%]). Factors associated with blindness were cataracts (33 individuals [48.5% of those with blindness and 2.9% of total population; 95% CI, 1.9%-3.8%]), age-related macular degeneration (15 individuals [22.1% of those with blindness and 1.3% of total population; 95% CI, 0.7%-2.0%]), glaucoma (7 individuals [10.3% of those with blindness and 0.6% of total population; 95% CI, Key PointsQuestion What is the prevalence of Open Access. This is an open access article distributed under the terms of the CC-BY License.

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Section: Discussioncontrasting

confidence: 42%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Prevalence Factors Associated With Vision Impairment and Blindness Among Individuals 85 Years and Older in Russia

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“…Age-related macular degeneration (AMD) is the most common cause of irreversible vision impairment in industrialized countries 1 , 2 . The introduction of anti-vascular endothelial growth factor (anti-VEGF) intravitreal treatment has provided a significant improvement in visual and anatomical prognosis in patients with neovascular AMD (nAMD), and has resulted in significant reduction of AMD-related irreversible vision loss in developed countries 3 .…”

Section: Introductionmentioning

confidence: 99%

High frequency SD-OCT follow-up leading to up to biweekly intravitreal ranibizumab treatment in neovascular age-related macular degeneration

Tuerksever

Pruente

Hatz

2021

Sci Rep

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A remarkable proportion of neovascular age-related macular degeneration (nAMD) patients respond rather poorly to ranibizumab treatment, in spite of the minimum 4-week follow-up and treatment interval. Usually, retreatments are based on nAMD activity as evaluated by Spectral-domain Optical coherence Tomography (SD-OCT), biomicroscopic fundus examination and visual acuity changes. In this prospective pilot study, we aimed to study SD-OCT changes in a high-frequent follow-up manner (weekly (month 0–6), biweekly (month 7–12)) throughout the first year, which consequently led to intravitreal ranibizumab being administered up to biweekly. Best corrected visual acuity (BCVA) was already significantly improved at week 2. Central retinal thickness (CRT), intraretinal and subretinal fluid (SRF) were significantly improved from week 1 onwards. Half of the patients showed nAMD activity at week 2 or 3 and received the first retreatment earlier than 4 weeks after baseline injection. In total, 46% of retreatments were already applied 2 or 3 weeks after the previous treatment. Greater range of CRT and SRF fluctuation during follow-up was associated with lower final BCVA. Lower baseline BCVA and better SRF improvement at week 2 was associated with greater BCVA improvement. In conclusion, high-frequency SD-OCT follow-up provided a good option for adapting treatment in nAMD individually.

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Primary glaucomas in adults: Epidemiology and public health‐A review

Reis

Paula

Furtado

2022

Clinical Exper Ophthalmology

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Glaucoma is a mixed group of optic neuropathies that lead to irreversible visual field loss and blindness if left untreated. It is estimated that 3.5% of the global population aged 40 to 80 years have any glaucoma, being the primary open‐angle and the primary angle‐closure glaucoma the most prevalent forms. Although the age‐standardised prevalence of blindness caused by glaucoma has decreased substantially over the last decades, population growth and ageing impose many challenges in preventing glaucoma‐related morbidities on a global level. In addition, difficulties in diagnoses and treatment, along with its chronic and irreversible nature, urge the development and implementation of innovative approaches in confronting the disease. This manuscript reviews recent literature related to the epidemiology of primary glaucomas in adults, the risk factors attributed to the development of the disease, and discuss challenges and potential solutions from a public health perspective.

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Prevalence and causes of vision impairment and blindness in the Russian ural eye and medical study

Cited by 10 publications

References 26 publications

Prevalence Factors Associated With Vision Impairment and Blindness Among Individuals 85 Years and Older in Russia

Prevalence Factors Associated With Vision Impairment and Blindness Among Individuals 85 Years and Older in Russia

High frequency SD-OCT follow-up leading to up to biweekly intravitreal ranibizumab treatment in neovascular age-related macular degeneration

Primary glaucomas in adults: Epidemiology and public health‐A review

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