Prevalence and Characteristics of Coeliac Disease in Type 1 Diabetes Mellitus

Cacciari, E; Salardi, S; Volta, Umberto; Biasco, Guido; Partesotti, S; Mantovani, W; Cicognani, Alessandro; Tonioli, S; Tassoni, P; Pirazzoli, Piero; Bianchi, Francesco; Barboni, F; Pisi, E

doi:10.1111/j.1651-2227.1987.tb10542.x

Cited by 43 publications

(17 citation statements)

References 7 publications

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“…Others have previously shown no difference in growth parameters regardless of dietary compliance (20). Within case subjects, the start of a GFD resulted in further significant improvement in mean HbA 1c levels compared with pre-GFD, confirming findings of some studies (24,27) but not others (13,14,19,25).…”

Section: Effect Of Gfdsupporting

confidence: 74%

A Longitudinal Study of the Effects of a Gluten-Free Diet on Glycemic Control and Weight Gain in Subjects With Type 1 Diabetes and Celiac Disease

et al. 2002

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OBJECTIVE—To describe the longitudinal growth characteristics and glycemic control in type 1 diabetic children diagnosed with celiac disease and started on a gluten-free diet (GFD). RESEARCH DESIGN AND METHODS—Data on growth and glycemic control for 11 case subjects diagnosed with celiac disease (cd+ group) and started on a GFD were collected prospectively, and two control subjects without celiac disease matched for age, sex, and duration of diabetes (cd− group) were selected for comparison. RESULTS—In the period between diagnosis of type 1 diabetes and start of a GFD in the cd+ compared with the cd− group, BMI standard deviation score (SDS) was lower (–0.2 vs. 0.7, P = 0.015), as was HbA1c (8.9 vs. 9.8%, P = 0.002). In a regression model the cd+ group had lower BMI SDS (P < 0.001) and lower HbA1c (P = 0.04), independent of other variables. On a GFD, BMI SDS increased by 12 months in the cd+ group and then was no different than the cd− group (1.1 vs. 1.0, P = 0.11), whereas HbA1c improved further within case subjects compared with pre-GFD (8.9 vs. 8.3%, P = 0.002). On a GFD, case subjects in contrast to control subjects showed no deterioration in HbA1c during the years of puberty (8.3 vs. 10.0%, P = 0.022) CONCLUSIONS—In children with type 1 diabetes, untreated celiac disease resulted in lower BMI SDS and lower HbA1c. Recovery of BMI SDS with a GFD was associated with further improvement in HbA1c as compared with pre-GFD, with no expected deterioration in glycemic control during puberty. These apparent clinical benefits need confirming by larger studies.

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Section: Effect Of Gfdsupporting

confidence: 74%

A Longitudinal Study of the Effects of a Gluten-Free Diet on Glycemic Control and Weight Gain in Subjects With Type 1 Diabetes and Celiac Disease

et al. 2002

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“…These children had symptoms that could be attributed to celiac disease but none had diarrhea or symptoms of malabsorbtion. In Italy, three studies using antigliadin antibodies, antireticulin antibodies, and AEAs as screening tests reported a prevalance of celiac disease among 146, 133, and 200 type 1 diabetic patients of 3.4, 3.7, and 4.0%, respectively (19)(20)(21). A study from Sweden showed a 6.2% prevalance among 115 diabetic children (22); another study from the United Kingdom showed a 4.8% prevalance among 167 children (23).…”

Section: Discussionmentioning

confidence: 92%

Celiac Disease in an Adult Turkish Population with Type 1 Diabetes Mellitus

et al. 2005

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Celiac disease is a frequent cause of morbidity among patients with type 1 diabetes mellitus. In this study our objective was to determine the prevalance of celiac diasease in a Turkish adult population with type 1 diabetes mellitus. Patients included 122 type 1 diabetes cases from adult diabetes clinic. Total IgA and IgA-antiendomysial antibody (AEA) assays were performed. Patients positive for IgA-AEA were asked to undergo small intestinal biopsy. Of the 122 patients, none was IgA deficient and 3 had positive IgA-AEA results (2.45%). All three of these patients had biopsies diagnostic of celiac disease. The body mass index (BMI) values of patients with positive AEA were significantly lower than normal (P = 0.024). Among the gastrointestinal complaints there was an association between early satiety and AEA positivity (P = 0.02). None of the other gastrointestinal complaints or age, duration of diabetes, glycosylated hemoglobin values, or insulin doses used were found to be related to AEA positivity. Celiac disease has a high prevalence among Turkish paients with type 1 diabetes mellitus. Screening for IgA-AEA during routine investigations of type 1 diabetic patients is important to prevent celiac-associated symptoms.

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“…At the time of screening most children do not have gastrointestinal symptoms[18–21,23,25,26,28,31,32,37] but failure to thrive[34] and severe gastrointestinal symptoms[24,34] may occur. Mild gastrointestinal symptoms may only be recognized in retrospect[34].…”

Section: Screening For Coeliac Disease In Diabetesmentioning

confidence: 99%

Coeliac disease and Type 1 diabetes mellitus – the case for screening

2001

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Coeliac disease commonly occurs in Type 1 diabetes. It is recommended that screening for coeliac disease should be part of the routine investigation and offered to all patients because of the high prevalence and the potential benefits of treatment with a GFD. This includes control of symptoms, stabilization of diabetes and prevention of complications associated with coeliac disease. The cost per patient diagnosed with coeliac disease from the existing population with Type 1 diabetes would be pound860 and for those newly arising pound950.

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Prevalence and Characteristics of Coeliac Disease in Type 1 Diabetes Mellitus

Cited by 43 publications

References 7 publications

A Longitudinal Study of the Effects of a Gluten-Free Diet on Glycemic Control and Weight Gain in Subjects With Type 1 Diabetes and Celiac Disease

A Longitudinal Study of the Effects of a Gluten-Free Diet on Glycemic Control and Weight Gain in Subjects With Type 1 Diabetes and Celiac Disease

Celiac Disease in an Adult Turkish Population with Type 1 Diabetes Mellitus

Coeliac disease and Type 1 diabetes mellitus – the case for screening

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