Prevalence and characteristics of diffuse idiopathic skeletal hyperostosis (DISH) in Italy

Ciaffi, Jacopo; Borlandelli, Elena; Visani, Gaia; Facchini, Giancarlo; Miceli, Marco; Ruscitti, Piero; Cipriani, Paola; Giacomelli, Roberto; Ursini, F.

doi:10.1007/s11547-022-01545-x

Cited by 8 publications

(3 citation statements)

References 57 publications

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“…4,5 Literature has also found that males have a higher prevalence of DISH. 8,[11][12][13] This study found that patients with DISH had a higher prevalence of diabetes mellitus, congestive heart failure, and dementia. Previous studies have also shown higher prevalence of DISH in patients with DM.…”

Section: Resultsmentioning

confidence: 66%

“…Previous literature has found the average at which DISH was diagnosed was between 57 years old and 68 years old, similar to but slightly younger than the mean age shown in the present study's DISH cohort. [6][7][8]12 There is an increased prevalence of DISH at older ages. 4,5 Literature has also found that males have a higher prevalence of DISH.…”

Section: Resultsmentioning

confidence: 99%

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Diffuse Idiopathic Skeletal Hyperostosis: Prevalence and Risk Factors

Madariaga,

Groff,

O’Malley

et al. 2024

Preprint

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Background Diffuse Idiopathic Skeletal Hyperostosis (DISH) is a degenerative disease of the spine which has been estimated to affect anywhere from 8–37% of the population. In addition, previous literature has shown an association between DISH and serious disability including dysphagia. Previous research detailing prevalence and risk factors for DISH, however, have been limited by studying homogenous populations. Methods Patients who received CT scans of the spine during hospital admission were included. Demographic data including age, sex, race/ethnicity, smoking history, alcohol use, and comorbidities were collected via chart review. DISH was defined as the presence of flowing ossifications along ≧ 4 contiguous vertebral bodies on CT. The location, number of levels, and side of ossification were also collected. Results were analyzed using t-test and chi-square analyses. Significance was set to p < 0.05 Results 1097 patients with CT scans were identified, revealing a DISH prevalence of 20.3%. Patients with DISH were significantly older than those without DISH and had significantly higher CCI scores when compared to the non-DISH cohort. Significant differences were also observed between ethnic groups. Men were found to have a significantly higher prevalence of DISH when compared to women. Finally, those with DM, PVD, Dementia, COPD, and CHF were noted to have higher prevalence of DISH when compared to those without DISH.

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Section: Resultsmentioning

confidence: 66%

Section: Resultsmentioning

confidence: 99%

Diffuse Idiopathic Skeletal Hyperostosis: Prevalence and Risk Factors

Madariaga,

Groff,

O’Malley

et al. 2024

Preprint

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“…DISH primarily affects older individuals, while axSpA affects a younger population. DISH has a prevalence ranging from 3.8% [6] to 30% [7][8][9][10][11][12][13][14][15] in people aged > 50 years. The prevalence of DISH is increasing with age [16].…”

Section: Similarities and Differences In Epidemiology And Demographicsmentioning

confidence: 99%

Diffuse idiopathic skeletal hyperostosis and axial spondyloarthritis—similarities and differences

Kiefer,

Khan,

Baraliakos

2023

Explor Musculoskeletal Dis

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Diffuse idiopathic skeletal hyperostosis (DISH) and axial spondyloarthritis (axSpA) are diseases with inflammatory involvement of the axial skeleton that can result in new bone formation that may lead to total ankylosis of the spine and functional impairment of different extent in individual patients. In these diseases, the new bone formation may lead to total ankylosis of the spine and impaired mobility with functional impairment. This review will highlight the similarities and differences of these two conditions. In axSpA, the genetic background with the association with human leukocyte antigen-B27 (HLA-B27) is known for 50 years, while in DISH, a genetic contribution is not yet proven. The phenotype of new bone formation and its anatomic features are different between these diseases. In axSpA symmetric, thin and marginal syndesmophytes representing an ossification of enthesitic inflammation at the area of the attachment of the annulus fibrosus that may extend to the adjacent deeper layers anterior longitudinal ligament and are typical, while in DISH the so-called “chunky bridging osteophytes” grow as an additional layer on the anterior longitudinal ligament. Besides distinct anamnestic and clinical features, magnetic resonance imaging is helpful differentiating the two diseases since inflammatory changes with the typical pattern of axSpA are reliably visualized. Similar in both diseases is the high prevalence of vertebral fractures, which are mainly caused by the local osteoporosis and decreased flexibility of the affected bones, and therefore may occur even after minor traumata. The presence of extraarticular manifestations like uveitis, inflammatory bowel disease or psoriasis are only linked to axSpA. In contrast, DISH is associated with obesity, diabetes mellitus, and other metabolic diseases. Although DISH and axSpA are distinct conditions, the cooccurrence of these two diseases exists in some patients. Various therapeutic options are becoming available for axSpA, but no therapy has been approved for DISH yet.

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