Prevalence and characteristics ofStaphylococcus aureusand methicillin‐resistantStaphylococcus aureusnasal colonization among a community‐based diabetes population in Foshan, China

Abstract

Aims/IntroductionEvidence suggests that diabetes might cause an increase in colonization of Staphylococcus aureus (S. aureus) and methicillin‐resistant S. aureus (MRSA) in community settings. We carried out a cross‐sectional study to determine the prevalence and influencing factors of S. aureus and MRSA nasal colonization among a community‐based diabetes population, and to identify the characteristics of the isolated strains.Materials and MethodsA total of 956 participants from 11 community settings were included in the study.ResultsOf the 529 diabetes participants, 46 were colonized with S. aureus and 22 were colonized with MRSA. Of the 427 non‐diabetes participants, 25 were colonized with S. aureus and 12 were colonized with MRSA. Men (odds ratio 0.45, 95% confidence interval 0.20–0.99, P = 0.047) were less likely to have S. aureus nasal colonization, and those with well‐controlled blood glucose (odds ratio 2.04, 95% confidence interval 1.01–4.13, P = 0.047) among the diabetes population were more likely to have S. aureus nasal colonization. The proportion of multidrug‐resistant S. aureus strains in the diabetes population (52.17%) was higher than that in the non‐diabetes population (28.00%; χ2 = 3.848, P = 0.050). The most common clonal complex type and Staphylococcal chromosome cassette mec type of MRSA in diabetes population was clonal complex 5 (40.91%) and type IV (27.27%), respectively. The proportion of Panton–Valentine leukocidin gene in MRSA strains was 17.65%. There was great sequence type diversity in MRSA strains.ConclusionsThe prevalence of MRSA in the community‐based diabetes population was moderate, and the high proportions of multidrug‐resistant S. aureus strains and diverse molecular characteristics in the diabetes population should be noticed.

The microbiology of diabetic foot infections: a meta-analysis

“…Diabetic patients are thought to have a higher chance of being colonized or infected by MRSA than non-diabetic patients [ 26 , 27 ]. S. aureus isolates were detected in 109 of the 112 studies.…”

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“…28,29 Several studies have shown the rate of MRSA colonization as high as 27% to 56.6% in diabetic patients, significantly greater than their nondiabetic controls. [28][29][30][31][32][33] These results indicate that it is especially important for patients with diabetes to have preoperative decolonization of MRSA. Since these patients are prone to recolonization with MRSA, post-op prophylaxis against MRSA may be effective in preventing tissue expansion-related infections.…”

“…It has been reported that DM is one of the most significant risk factors for MRSA colonization and subsequent infection. 28,29 Several studies have shown the rate of MRSA colonization as high as 27% to 56.6% in diabetic patients, significantly greater than their nondiabetic controls. 28 -33 These results indicate that it is especially important for patients with diabetes to have preoperative decolonization of MRSA.…”

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