Prevalence and characteristics of  -lactamase and plasmid-mediated quinolone resistance genes in Escherichia coli isolated from farmed fish in China

Jiang, Hongxia; Dian, Tang; Liu, Yahong; Zhang, Xiaohua; Zeng, Zhenling; Xu, Liang; Hawkey, Peter M.

doi:10.1093/jac/dks250

Cited by 119 publications

(105 citation statements)

References 23 publications

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“…This means that both quinolones and ESBL resistant genes were more likely to coexist on the same plasmid. Demonstration of high levels existence of mobile genes conferring reduced susceptibility to fluroquinolones as well as the presence of ESBL genes in fish produced in China and identification of a significant reservoir of antibiotic resistance genes relevant to human medicine was detected by Jiang et al (2012). Therefore, these findings are of a great clinical and environmental importance for horizontal transfer of various resistant genes among population of clinically relevant pathogens.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial resistance pattern of aerobic bacteria isolated from patients with diabetic foot ulcers in Egypt

Noha¹,

Mohammad²,

Wafaa³

et al. 2014

Afr. J. Microbiol. Res.

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Section: Discussionmentioning

confidence: 99%

Antibacterial resistance pattern of aerobic bacteria isolated from patients with diabetic foot ulcers in Egypt

Noha¹,

Mohammad²,

Wafaa³

et al. 2014

Afr. J. Microbiol. Res.

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“…CTX-M-79, an Asp287Asn variant of CTX-M-55 (Ambler numbering), was first detected in China (32). So far, this enzyme had been isolated only from humans and farmed fish in China and from cattle in Ohio, USA (33,34). Interestingly, SHV-12, first reported in Switzerland in 1997 (35), had been predominant in human clinical isolates in Switzerland and disseminated worldwide during the following decades but was detected in the present study in only three environmental isolates.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae Isolates from Rivers and Lakes in Switzerland

Zurfluh

Hächler

Nüesch‐Inderbinen

et al. 2013

Appl Environ Microbiol

257

163

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One of the currently most relevant resistance mechanisms in Enterobacteriaceae is the production of enzymes that lead to modern expanded-spectrum cephalosporin and even carbapenem resistance, mainly extended-spectrum ␤-lactamases (ESBLs) and carbapenemases. A worrisome aspect is the spread of ESBL and carbapenemase producers into the environment. The aim of the present study was to assess the occurrence of ESBL-and carbapenemase-producing Enterobacteriaceae and to further characterize ESBL-and carbapenemase-producing Enterobacteriaceae in rivers and lakes in Switzerland. ESBL-producing Enterobacteriaceae were detected in 21 (36.2%) of the 58 bodies of water sampled. One river sample tested positive for a carbapenemase-producing Klebsiella pneumoniae subsp. pneumoniae strain. Seventy-four individual strains expressing an ESBL phenotype were isolated. Species identification revealed 60 Escherichia coli strains, seven Klebsiella pneumoniae subsp. pneumoniae strains, five Raoultella planticola strains, one Enterobacter cloacae strain, and one Enterobacter amnigenus strain. Three strains were identified as SHV-12 ESBL producers, and 71 strains carried genes encoding CTX-M ESBLs. Of the 71 strains with CTX-M ESBL genes, 8 isolates expressed CTX-M-1, three produced CTX-M-3, 46 produced CTX-M-15, three produced CTX-M-55, one produced CTX-M-79, six produced CTX-M-14, and four produced CTX-M-27. Three of the four CTX-M-27 producers belonged to the multiresistant pandemic sequence type E. coli B2:ST131 that is strongly associated with potentially severe infections in humans and animals.

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“…Additionally, plasmid-mediated AmpC beta-lactamases and, even more alarming, carbapenemases are leading to a worsening of the situation in both human and veterinary medicine (13). Although the resistant bacteria were initially observed in human samples, an increase in the detection of ESBL/AmpC-producing E. coli in animals, such as pigs (9,14), horses (15), cattle, dogs, cats (4,15), fish (16), and, particularly, broiler chickens, has been reported worldwide (3,8,12,14). The gastrointestinal tract of healthy broilers may be an important reservoir for these beta-lactamase-producing bacteria (11).…”

mentioning

confidence: 99%

Longitudinal Monitoring of Extended-Spectrum-Beta-Lactamase/AmpC-Producing Escherichia coli at German Broiler Chicken Fattening Farms

Laube¹,

Friese²,

Salviati³

et al. 2013

Appl Environ Microbiol

133

106

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Antimicrobial resistance of Escherichia coli to modern beta-lactam antibiotics due to the production of extended-spectrum betalactamases (ESBL) and/or plasmid-mediated AmpC beta-lactamases (AmpC) represents an emerging and increasing resistance problem that dramatically limits therapeutic options in both human and veterinary medicine. The presence of ESBL/AmpC genes in commensal E. coli from food-producing animals like broilers may pose a human health hazard. However, there are no data available concerning the prevalence of ESBL/AmpC-producing E. coli in German broiler flocks using selective methods. In this longitudinal study, samples were taken from seven conventional broiler fattening farms at three different times within one fattening period. Various samples originating from the animals as well as from their direct environment in the barn were investigated for the occurrence of ESBL/AmpC-producing E. coli. Average detection levels of 51, 75, and 76% in animal samples collected during the three samplings in the course of the fattening period demonstrate a colonization of even 1-day-old chicks, as well as a continuous significant (P < 0.001) increase in prevalence thereafter. The detection frequencies in housing environmental samples were relatively high, with an increase over time, and ranged between 54.2 and 100%. A total of 359 E. coli isolates were characterized by PCR and partly via the disc diffusion method. This study shows that prevalence of ESBL/AmpC-producing E. coli increases during the fattening period of the broiler flocks examined. Both colonized day-old chicks and contaminated farm environments could represent significant sources of ESBL/AmpC-producing E. coli in German broiler fattening farms.

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Prevalence and characteristics of -lactamase and plasmid-mediated quinolone resistance genes in Escherichia coli isolated from farmed fish in China

Cited by 119 publications

References 23 publications

Antibacterial resistance pattern of aerobic bacteria isolated from patients with diabetic foot ulcers in Egypt

Antibacterial resistance pattern of aerobic bacteria isolated from patients with diabetic foot ulcers in Egypt

Characteristics of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae Isolates from Rivers and Lakes in Switzerland

Longitudinal Monitoring of Extended-Spectrum-Beta-Lactamase/AmpC-Producing Escherichia coli at German Broiler Chicken Fattening Farms

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