Prevalence and characteristics of nodular gastritis in <scp>J</scp>apanese elderly

Kitamura, Shinji; Yasuda, Mitsugi; Muguruma, Naoki; Okamoto, Koichi; Takeuchi, Hisashi; Bando, Yoshimi; Miyamoto, Hiroshi; Okahisa, Toshiya; Yano, Mitsuyasu; Torisu, Ryusuke; Takayama, Tetsuji

doi:10.1111/jgh.12180

Cited by 18 publications

(12 citation statements)

References 20 publications

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“…Gastric atrophy is rare in NG patients ; therefore, there are low levels of PG I and a decrease of the PG I/II ratio and hypergastrinemia in the serum . Our results agree with those of previous studies and, consequently, also indicated that there was no severe atrophy and hypochlorhydria in patients with NG.…”

Section: Discussionsupporting

confidence: 92%

The Relationship Between Iron Deficiency in Patients with Helicobacter Pylori‐Infected Nodular Gastritis and the Serum Prohepcidin Level

et al. 2014

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Section: Discussionsupporting

confidence: 92%

The Relationship Between Iron Deficiency in Patients with Helicobacter Pylori‐Infected Nodular Gastritis and the Serum Prohepcidin Level

et al. 2014

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“…In this study, six (5%) cases of gastric cancers, all of which were of the diffuse type, were observed in patients with NG. Previous reports indicate that NG is a risk factor for the development of diffuse‐type gastric cancer in the gastric corpus, and our results were in line with those of previous reports. NG appears to increase the risk of developing diffuse‐type cancer due to highly active gastric inflammation and lower levels of atrophy.…”

Section: Discussionsupporting

confidence: 94%

“…Observational studies of Japanese adults with NG have suggested an association with gastric cancer, particularly diffuse‐type gastric cancer . However, the biological and epidemiological associations between NG and cancer development are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4]9 Observational studies of Japanese adults with NG have suggested an association with gastric cancer, particularly diffusetype gastric cancer. 3,5,10,11 However, the biological and epidemiological associations between NG and cancer development are largely unknown. Few reports exist on the differences in clinical course and cancer development between patients with H. pylori infections with and without NG.…”

Section: Introductionmentioning

confidence: 99%

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Nodular gastritis in association with gastric cancer development before and after Helicobacter pylori eradication

et al. 2018

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Background and AimNodular gastritis is caused by Helicobacter pylori infection and is associated with the development of diffuse‐type gastric cancer. This study examined the clinical characteristics of patients with nodular gastritis, including cancer incidence before and after H. pylori eradication.MethodsThis was a retrospective study of patients who underwent upper endoscopy and were positive for H. pylori infection. We examined the clinical findings and follow‐up data after H. pylori eradication in patients with and without nodular gastritis.ResultsOf the 674 patients with H. pylori infections, nodular gastritis was observed in 114 (17%). It was more prevalent in women (69%) and young adults. Among patients with nodular gastritis, six (5%) had gastric cancer, all of which were of the diffuse type. Among the 19 (4%) patients with gastric cancer and no nodular gastritis, 16 had intestinal‐type cancer. White spot aggregates in the corpus, a specific finding in patients with nodular gastritis, were more frequently observed in patients with gastric cancer than in those without (83% vs 26%, P = 0.0025). Of 82 patients with nodular gastritis who had H. pylori eradicated successfully, none developed gastric cancer over a 3‐year follow‐up period, while 7 (3%) of 220 patients without nodular gastritis developed gastric cancer after H. pylori eradication.ConclusionsIn patients with nodular gastritis, white spot aggregates in the corpus may indicate a higher risk of developing diffuse‐type gastric cancer. Nodular gastritis may be an indication for eradication therapy to reduce the risk of cancer development after H. pylori eradication.

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“…The prognosis differs in adults with NG; some might progress to a diffuse-type gastric cancer and a few may progress to a lymphofollicular malignancy [ 9 , 10 ]. Several studies have found reductions in symptoms and in the risk of peptic ulcers and possibly gastric cancer following H. pylori eradication [ 5 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Nodule Regression in Adults With Nodular Gastritis

et al. 2015

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BackgroundNodular gastritis (NG) is associated with the presence of Helicobacter pylori infection, but there are controversies on nodule regression in adults. The aim of this study was to analyze the factors that are related to the nodule regression in adults diagnosed as NG.MethodsAdult population who were diagnosed as NG with H. pylori infection during esophagogastroduodenoscopy (EGD) at our center were included. Changes in the size and location of the nodules, status of H. pylori infection, upper gastrointestinal (UGI) symptom, EGD and pathology findings were analyzed between the initial and follow-up tests.ResultsOf the 117 NG patients, 66.7% (12/18) of the eradicated NG patients showed nodule regression after H. pylori eradication, whereas 9.9% (9/99) of the non-eradicated NG patients showed spontaneous nodule regression without H. pylori eradication (P < 0.001). Nodule regression was more frequent in NG patients with antral nodule location (P = 0.010), small-sized nodules (P = 0.029), H. pylori eradication (P < 0.001), UGI symptom (P = 0.007), and a long-term follow-up period (P = 0.030). On the logistic regression analysis, nodule regression was inversely correlated with the persistent H. pylori infection on the follow-up test (odds ratio (OR): 0.020, 95% confidence interval (CI): 0.003 - 0.137, P < 0.001) and short-term follow-up period < 30.5 months (OR: 0.140, 95% CI: 0.028 - 0.700, P = 0.017).ConclusionsIn adults with NG, H. pylori eradication is the most significant factor associated with nodule regression. Long-term follow-up period is also correlated with nodule regression, but is less significant than H. pylori eradication. Our findings suggest that H. pylori eradication should be considered to promote nodule regression in NG patients with H. pylori infection.

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Prevalence and characteristics of nodular gastritis in Japanese elderly

Abstract: NG in the elderly was also suggested to be a risk factor for gastric cancer as well as in the young.

Cited by 18 publications

References 20 publications

The Relationship Between Iron Deficiency in Patients with Helicobacter Pylori‐Infected Nodular Gastritis and the Serum Prohepcidin Level

The Relationship Between Iron Deficiency in Patients with Helicobacter Pylori‐Infected Nodular Gastritis and the Serum Prohepcidin Level

Nodular gastritis in association with gastric cancer development before and after Helicobacter pylori eradication

Nodule Regression in Adults With Nodular Gastritis

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