Prevalence and Characterization of Thrombocytopenia in Pregnancy in Indian Women

Singh, Nisha; Dhakad, Amita; Uma, Singh; Tripathi, Anil Kumar; Sankhwar, Pushp Lata

doi:10.1007/s12288-011-0107-x

Cited by 47 publications

(67 citation statements)

References 18 publications

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“…The results of this study were consistent with our study findings. 18 In a study done in Ege University in Turkey assessing thrombocytopenia in pregnancy, around 43.5% of thrombocytopenia was due to HELLP syndrome followed by gestational thrombocytopenia (39.5%) and ITP was around 16%. 19 Fifty percent of patients were primigravida and 14% of patients had advanced maternal age.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of thrombocytopenia in pregnancy

Begam

Nambisan

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Thrombocytopenia in pregnancy occurs due to several etiologies which include both pregnancy specific and non pregnancy related causes. It is second only to anemia as the most common hematological abnormality encountered in pregnancy. Better antenatal care has led to increased detection. Once diagnosed, it is important to further evaluate and to determine the cause to optimize management. Several studies have been undertaken across the world; however there are very few studies in Kerala hence this study. The aim of this study was to determine the risk factors of thrombocytopenia in pregnancy.Methods: This was a case control study undertaken in the Department of Obstetrics and Gynecology, Medical college Hospital, Trivandrum, Kerala. Using purposive sampling, a sample size of 96 cases and 96 controls were included in this study. “Cases” were antenatal women with thrombocytopenia and “controls” were consecutive women without it. Study period was 18 months and analysis was done using SPSS version 22.Results: In 49% of subjects ,the cause was identified as gestational thrombocytopenia,39.5% cases were due to hypertensive disorders of pregnancy.10.4% was due to ITP. SLE, AFLP, Dengue infection, HUS and APLA were rare causes of thrombocytopenia in our hospital. Of the 96 cases enrolled in the study,88 were diagnosed during pregnancy. Amongst the hypertensive disorders,16.7% was due to gestational hypertension,10.4% due to preeclampsia and 7.4% were due to HELLP syndrome.82.3% of patients with thrombocytopenia in this study were asymptomatic.Conclusions: Thrombocytopenia should be evaluated by making a practice of routinely checking the platelet count and peripheral smear in early pregnancy and also in third trimester to enable early diagnosis since most cases may be asymptomatic.

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Section: Discussionmentioning

confidence: 99%

Risk factors of thrombocytopenia in pregnancy

Begam

Nambisan

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…It may result in bleeding into mucous membranes presenting as petechiae, ecchymosed, epistaxis, gingival bleeding etc. Moreover, bruising, hematuria, gastrointestinal bleeding and rarely intracranial hemorrhage can occur 10 .…”

Section: Discussionmentioning

confidence: 99%

Gestational Thrombocytopenia: Does it cause any Maternal and/or Perinatal Morbidity?

Pafumi¹

2012

Gynecol Obstet

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Purpose: The aim of this study was to retrospectively evaluate maternal platelet count fluctuation during pregnancy and puerperium and its correlation with the newborn's platelet levels. Material and Methods: A group of 36 patients who have been referred to a haematology-clinic for gestational thrombocytopenia (GT) and who delivered at the same hospital during a period of 4 years, from January 2006 to December2009 were included in the study. Mothers and their related foetuses-newborns were evaluated retrospectively for symptoms and/or signs of external and internal haemorrhage throughout pregnancy and early puerperium, even in relationship with mode of delivery (caesarean section versus spontaneous vaginal delivery).Results: All observed cases of GT have an uncomplicated course with no related perinatal and maternal morbidity even in patients with initial platelet count < 75.000/ml independently from the route of delivery. gestasyonel trombositopeniden (GT) dolayı hematoloji kliniğinde tedavi görmüş ve doğum yapmış 36 hasta oluşturmaktadır. Anneler ve onlara ait fetusler ile yeni doğanlar hamilelik ve lohusalığın erken dönemleri boyunca iç ve dış kanama (doğum şekli ile ilişkili durumlarda dahil-Normal doğumla sezeryan doğum karşılaştırılması) gibi belirtiler ve/veya semptomlar açısından geriye dönük olarak değerlendirilmiştir. Bulgular: Gestasyonel trombositopenili tüm vakalarda hastalık maternal ve perinatal morbidite ile ilgili olmaksızın, doğumun gidişatından bağımsız olarak başlangıçta ki trombosit sayısı< 75.000/ml. olduğu halde, komplike olmayan bir seyire sahiptir. Sonuç: Her ne kadar rastlantısal olarak eşlik eden neonatal trombositopeni gözardı edilemesede, gestasyonel trombositopeni durumunda maternal trombosit sayısının standardizasyonun postpartum dönemde gerçekleşmesi beklenmelidir. Bu gibi durumlarda fetal trombosit sayısının belirlenmesi veya sezeryan doğum gibi müdahaleler gerekmemektedir.

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“…6 In our study majority of women had moderate thrombocytopenia (49%) at the time of delivery, 26% had severe thrombocytopenia and 25% had mild thrombocytopenia this is in contrast to other studies where they observed mild to moderate thrombocytopenia during delivery time. 2,5,9 The aim of management in these cases is to achieve and maintain a 'safe' rather than normal platelet count. An experienced team and an individualized approach are important.…”

Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 99%

“…1 The normal range of platelets in non-pregnant women is 150,000-400,000/µ L. Average platelet count in pregnancy is decreased 180,000-213,000 versus 250,000/µL. 2 Classification of thrombocytopenia in pregnancy is similar to non-pregnant patients. Mild thrombocytopenia is 100,000-150,000/µL.…”

Section: Introductionmentioning

confidence: 99%

“…4 Most common cause of thrombocytopenia reported by several authors is gestational thrombocytopenia (70-80%) followed by hypertensive disorders (15-20%), idiopathic thrombocytopenic purpura (1-4%) and other rare causes. 2,3 The diagnosis of specific disorder is often difficult because the time of onset of these disorders during pregnancy and their clinical manifestations often overlap.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of thrombocytopenia in Parturient: Experience in Tertiary Care Center

2020

IJOGR

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Introduction: Thrombocytopenia can result from a wide range of conditions with several of them being pregnancy related. Obstetricians manage most cases of pregnancy-associated thrombocytopenia. Thus, a working knowledge of the clinical features and management of thrombocytopenia in pregnant women is important. The objective of the study was to evaluate the causes of thrombocytopenia and its effect on maternal and neonatal outcome in parturient women and also evaluate the obstetric risk factors, complications, and outcome of pregnancies complicated by thrombocytopenia. Materials and Methods: A prospective study of 100 antenatal women with thrombocytopenia who delivered at St John's Medical College Hospital during a one and a half year period. The blood samples of pregnant women in labor room were collected at the time of admission. These women were followed up till they deliver. Results:The main causes of thrombocytopenia were hypertensive disorders: preeclampsia (15%), Hemolysis, elevated liver enzymes, and low platelets (24%) and eclampsia (4%); idiopathic thrombocytopenic purpura (16%), gestational thrombocytopenia (11%). Women with hypertensive disorders had higher rates of cesarean delivery (65%), intrauterine growth restriction (30%) and preterm deliveries (31%). Hemorrhagic complications are common in rarer causes of thrombocytopenia. Conclusion:The adverse outcome is specifically attributed to preeclampsia, HELLP syndrome and rare causes. While the perinatal outcome of GT and ITP is basically favorable. Careful surveillance is required for these women in high-risk units for early detection and treatment of possible complications, in order to reduce adverse maternal and neonatal outcomes.

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Prevalence and Characterization of Thrombocytopenia in Pregnancy in Indian Women

Cited by 47 publications

References 18 publications

Risk factors of thrombocytopenia in pregnancy

Risk factors of thrombocytopenia in pregnancy

Gestational Thrombocytopenia: Does it cause any Maternal and/or Perinatal Morbidity?

Prevalence of thrombocytopenia in Parturient: Experience in Tertiary Care Center

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