Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis

Paudel, Klara

doi:10.7860/jcdr/2014/7821.4246

Cited by 16 publications

(17 citation statements)

References 33 publications

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“…Increased thyroid gland volume 1 and an increased prevalence of goiter 2,3 have been observed, potentially related to altered iodine metabolism, autoimmune, and uremic factors. 3,5 Cases of reversible primary hypothyroidism with iodine restriction have been reported in patients with mild to severe renal dysfunction and those receiving maintenance hemodialysis, suggesting that impaired renal excretion of iodine may contribute to the observed association between hypothyroidism and chronic kidney disease (CKD). 3,5 Cases of reversible primary hypothyroidism with iodine restriction have been reported in patients with mild to severe renal dysfunction and those receiving maintenance hemodialysis, suggesting that impaired renal excretion of iodine may contribute to the observed association between hypothyroidism and chronic kidney disease (CKD).…”

Section: Introductionmentioning

confidence: 99%

“…4 Existing data suggest that primary hypothyroidism is more common in patients with ESRD compared with the general population. 3,5 Cases of reversible primary hypothyroidism with iodine restriction have been reported in patients with mild to severe renal dysfunction and those receiving maintenance hemodialysis, suggesting that impaired renal excretion of iodine may contribute to the observed association between hypothyroidism and chronic kidney disease (CKD). 6,7 These observations are of interest, given that 2 large observational studies reported an inverse graded relation between kidney function and risk of prevalent clinical or subclinical hypothyroidism within the general population 8,9 and among patients with moderate to severe CKD.…”

Section: Introductionmentioning

confidence: 99%

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Thyroid function in end stage renal disease and effects of frequent hemodialysis

Beck

Kaysen

et al. 2017

Hemodialysis International

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thyroid function in end stage renal disease and effects of frequent hemodialysis

Beck

Kaysen

et al. 2017

Hemodialysis International

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“…9 A study among HD patients in western Nepal showed the combined prevalence of subclinical and clinical hypothyroidism in 26.6 % patients. 10 Higher rate of thyroid dysfunction in CKD patients as observed in our study may also be due to high prevalence of thyroid autoimmunity in study population, excess iodine nutrition or iodine deficiency, and the inclusion of subjects with non-thyroidal illness. 11,12 We observed decreasing trend for free T3 and free T4 levels (though the decrease were not significant) and increasing trend for TSH level (significant rise) across CKD stages 3-5, which suggest that TSH level increases with the progression of renal impairment (which is indicated by a decrease in GFR).…”

Section: Discussionmentioning

confidence: 46%

Prevalence of hypothyroidism in chronic kidney disease: a single centre cross-sectional study

Pj¹,

Bishal²,

Manjuri³

2019

International Journal of Health Research and Medico Legal Practice

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Background: The kidney normally plays an important role in the metabolism, degradation and excretion of thyroid hormones. Chronic kidney disease (CKD) affects the hypothalamus pituitary thyroid axis and peripheral metabolism of thyroid hormone and thus affects thyroid function in many ways. Despite considerable overlap in the symptoms related to hypothyroidism and advanced chronic kidney disease, relatively little is known about the prevalence of thyroid abnormalities in persons with CKD. In patients with end-stage renal disease, it has been suggested that primary hypothyroidism may be more common in patients with end stage renal disease (ESRD) compared with the general population. Thus this study was conducted to estimate the prevalence of hypothyroid in CKD. Objectives: To study the prevalence of hypothyroid in CKD and to see if prevalence increases with advancement of CKD stage. Materials and methods: This study is a Cross-Sectional study that was conducted among nondialytic CKD patients attending Nephrology OPD of GMCH from March 2014 to Feb 2016. Out of 1742 CKD patients, 280 patients who met the study criteria were included in the study. Demographic features (age and sex) and medical history of each patient were noted at the time of diagnosis. Results: The mean age of patients with overt hypothyroid was 59.64 years, in sub-clinical hypothyroid group was 58.14 years, and in patients with normal thyroid function was 55.51 years. We observed that prevalence of hypothyroidism was increased in patients with reduced GFR, and it increases as estimated glomerular filtration rate (eGFR) decreases ranging from 13.33% in stage 2 to 35.55% in ESRD (end stage renal disease). We also found that 68.8% of hypothyroids have sub-clinical hypothyroidism. Conclusion: This study concludes that prevalence of hypothyroid in CKD is more than that of general population and it further increases as eGFR decreases.

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“…Our result was consistent with the finding of several previous studies. 17 A small study was conducted in CKD patients dependent on hemodialysis in western Uttar Pradesh. This study showed the combined prevalence (26.6% patients) of clinical and subclinical hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

Assessment of thyroid dysfunction, dyslipidemia and oxidative stress in hypertensive end stage chronic renal disease patients in a teaching hospital in Western Uttar Pradesh

Kachhawa

Sinha

2019

Asian J Med Sci

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Background: CKD is a serious health problem in worldwide. In developing nation, CKD has severe implication on health and economic output. The rapid increase of common risk factors such as hypertension (HTN), obesity and type 2 diabetes will result in greater and more burdens to developing country. There are many complications associated with CKD including thyroid dysfunction, dyslipidemia,hypertension and cardiovascular disease (CVD).It is generally seen that patients suffering from CKD are at high risk of cardiovascular disease. Aims and Objectives: The purpose of the study was to evaluate the diagnostic screening of thyroid dysfunction, dyslipidemia and oxidative stress in hypertensive end stage chronic renal disease patients. Materials and Methods: Thyroid status, Lipid profile, serum Urea, serum Creatinine, serum Uric acid, serum electrolyte, Catalase,Malondialdehyde (MDA) and Superoxide dismutase (SOD) were assayed in 160 subjects in which 80 patients of CKD were having hypertension and 80 healthy controls. Results: In our study, we found statistical significantly increased level of (p<0.001) of malondialdehyde (MDA) and significantly decreased level (p<0.001) of Catalase and Superoxide dismutase (SOD).There was found significantly increased level (p<0.001) of TSH in CKD associated with hypertension patients.We also found deranged lipid profile and renal functions in CKD associated with hypertension patients as compared to controls. Conclusion: In the present study, we arrived at conclusion that dyslipidemia and thyroid dysfunction is very common in CKD patients. Our study revealed that there was significant association between thyroid dysfunction and CKD progression and dyslipidemia. The antioxidant status is assessed through changes in antioxidant enzymatic activity in patients of CKD with hypertensive and data provide evidence of blood pressure modulation by measurable oxidative stress–related parameters.

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Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis

Abstract: Background: The prevalence of hypothyroidism in persons with chronic kidney disease is documented to be higher, compared to the normal population. However, no data is available about the prevalence rate of hypothyroidism among hemodialysis patients in Nepal.

Cited by 16 publications

References 33 publications

Thyroid function in end stage renal disease and effects of frequent hemodialysis

Thyroid function in end stage renal disease and effects of frequent hemodialysis

Prevalence of hypothyroidism in chronic kidney disease: a single centre cross-sectional study

Assessment of thyroid dysfunction, dyslipidemia and oxidative stress in hypertensive end stage chronic renal disease patients in a teaching hospital in Western Uttar Pradesh

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