Prevalence and clinical correlates of restless legs syndrome among psychogeriatric patients

Agüera-Ortíz, Luis; Perez, M. Isabel Ramos-García; Osorio, Ricardo S.; Sacks, Hayley; Palomo, Tomás

doi:10.1002/gps.2674

Cited by 14 publications

(12 citation statements)

References 31 publications

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“…Many studies have indicated that RLS is not associated with the use of antidepressants, and some studies have suggested that antidepressants might exacerbate RLS symptoms. [ 17 18 19 ] In addition, depression did not improve as significantly as the symptoms of RLS in our study. Thus, we believe that rTMS alleviates RLS directly rather than through the treatment of associated symptoms.…”

Section: Discussioncontrasting

confidence: 68%

Repetitive Transcranial Magnetic Stimulation for the Treatment of Restless Legs Syndrome

Lin

Feng

Zhan

et al. 2015

Chinese Medical Journal

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Background:Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique used to alter cortex excitability that has been proposed as an efficient method for treating brain hyperexcitability or hypoexcitability disorders. The aim of this study was to investigate whether high-frequency rTMS could have any beneficial effects in restless legs syndrome (RLS).Methods:Fourteen patients with RLS were given high-frequency rTMS (15 Hz, 100% motor threshold) to the leg representation motor cortex area of the frontal lobe for 14 sessions over 18 days. Patients were diagnosed according to the international criteria proposed by the International Restless Legs Syndrome Study Group in 2003. The International RLS Rating Scale (IRLS-RS), Pittsburgh Sleep Quality Index (PSQI), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale were used to evaluate the severity of RLS, sleep quality, anxiety and depression, respectively. The scale scores were evaluated at four-time points (baseline, end of the 14th session, and at 1- and 2-month posttreatment). One-way analysis of variance was used to compare scale scores at different time points.Results:There was significant improvement in the IRLS-RS (from 23.86 ± 5.88 to 11.21 ± 7.23, P < 0.05), PSQI (from 15.00 ± 4.88 to 9.29 ± 3.91, P < 0.05), and HAMA (from 17.93 ± 7.11 to 10.36 ± 7.13, P < 0.05) scale scores at the end of 14th session, with ongoing effects lasting for at least 2 months.Conclusions:High-frequency rTMS can markedly alleviate the motor system symptoms, sleep disturbances, and anxiety in RLS patients. These results suggest that rTMS might be an option for treating RLS.

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Section: Discussioncontrasting

confidence: 68%

Repetitive Transcranial Magnetic Stimulation for the Treatment of Restless Legs Syndrome

Lin

Feng

Zhan

et al. 2015

Chinese Medical Journal

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“…Population-/community-based studies 22,23,[29][30][31][32][33][34][35][36][37][38][39][40] and clinicbased studies 18,25,[41][42][43][44][45] have consistently demonstrated an increased prevalence or risk of depression and/or anxiety in 44 . In the majority of cases, the onset of RLS occurred prior to that of the psychiatric disorder.…”

Section: Depressive and Anxiety Disordersmentioning

confidence: 99%

Diagnosis, comorbidities, and management of restless legs syndrome

Becker

Novák

2014

Current Medical Research and Opinion

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Although clinical diagnosis of RLS can be straightforward, diagnostic challenges may arise when patients present with comorbid conditions. Comorbidities of RLS include insomnia, depressive and anxiety disorders, and pain disorders. Differential diagnosis is particularly important, as some of the medications used to treat insomnia and depression may exacerbate RLS symptoms. Appropriate diagnosis and management of RLS symptoms may benefit patient well-being and, in some cases, may lessen comorbid disease burden. Therefore, it is important that physicians are aware of the presence of RLS when treating patients with conditions that commonly co-occur with the disorder.

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“…Differential diagnosis may be difficult in cognitively impaired patients with affective disorders, who may have difficulty explaining their array of sensory complaints and distinguishing them from psychiatric complaints. 25 Recognition of RLS is particularly important in patients receiving treatment for mood disorders and anxiety, as some of the medications commonly used to treat insomnia and depression may result in exacerbation of RLS symptoms.…”

Section: Diagnosis Of Rlsmentioning

confidence: 99%

“…24 Among 99 elderly patients attending a Spanish psychiatric clinic, the prevalence of confirmed RLS was 11%. 25 An additional 10% of patients had "possible RLS"; the diagnosis could not be confirmed due to doubts regarding the accuracy and reliability of the information provided by the patient. None of the patients in the study had previously been diagnosed with RLS.…”

mentioning

confidence: 99%

Mood Disorders in Restless Legs Syndrome (Willis-Ekbom Disease)

Becker¹,

Sharon²

2014

J. Clin. Psychiatry

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Study Selection: 173 publications were retrieved. Articles related to the association between idiopathic RLS and depression, anxiety, and mood disorders were reviewed. In total, 32 epidemiologic studies were identified. These studies were reviewed in detail and ranked according to quality.Data Extraction: Data were extracted on the basis of relevance to the topic. Epidemiologic studies were assessed using 3 parameters: methodology, data quality, and generalizability of the results. Each factor was scored from 1 (high quality) to 4 (low quality), giving a total score of between 3 and 12 for each study.Results and Conclusions: RLS and mood disorders are frequently comorbid. Recognition and appropriate treatment of comorbid RLS are particularly important in patients with psychiatric disorders, as RLS is a common medical reason for insomnia, and antidepressant use may exacerbate sensory symptoms.

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Prevalence and clinical correlates of restless legs syndrome among psychogeriatric patients

Abstract: RLS is a frequent condition in psychogeriatric patients, especially among those with depression, and is commonly underdiagnosed and undertreated. Clinicians should routinely ask for RLS symptoms when assessing their patients in their regular clinical practice.

Cited by 14 publications

References 31 publications

Repetitive Transcranial Magnetic Stimulation for the Treatment of Restless Legs Syndrome

Repetitive Transcranial Magnetic Stimulation for the Treatment of Restless Legs Syndrome

Diagnosis, comorbidities, and management of restless legs syndrome

Mood Disorders in Restless Legs Syndrome (Willis-Ekbom Disease)

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