Prevalence and clinical impact of eating disorders in bipolar patients

Seixas, Camila; Miranda‐Scippa, Ângela; Nery-Fernandes, Fabiana; Andrade-Nascimento, Mônica; Quarantini, Lucas C.; Kapczinski, Flávio; Oliveira, Irismar Reis de

doi:10.1016/s1516-4446(12)70012-0

Cited by 24 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found that BD comorbid with ED was strongly associated with other comorbidities, including anxiety disorders, alcohol use disorders, and impulsiveness when accounting for age and sex. Our findings of high lifetime rates of EDs in a sample of BD patients are consistent with the findings of previous studies, suggesting that ED and BD are comorbid at a rate higher than what would be predicted through chance alone (McElroy et al 2011 ; McElroy et al 2006 2005 ; Brietzke et al 2011 ; Seixas et al 2012 ; Wildes et al 2008 ). As expected, comorbidity with ED was associated with female gender and earlier age at onset of BD by an average of 3.3 years.…”

Section: Discussionsupporting

confidence: 91%

“…EDs collectively include an alteration in hunger and satiation cues and overvaluing the role of body size and shape in self-image. Data demonstrate high comorbidity between BD and various EDs, especially among females (Fornaro et al 2010 ; McElroy et al 2011 ; Brietzke et al 2011 ; Seixas et al 2012 ). The estimated prevalence of ED in BD has varied widely but ranges between 6% and 27% in BD, many times greater than the population prevalence of 3.6% to 10% (McElroy et al 2005 2006 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impulsivity, anxiety, and alcohol misuse in bipolar disorder comorbid with eating disorders

Jen

Saunders

Ornstein

et al. 2013

Int J Bipolar Disord

View full text Add to dashboard Cite

BackgroundEating disorders (ED) are noted to occur with bipolar disorder (BD), but relationships between additional comorbidities, clinical correlates, and personality factors common to both remain largely unknown.MethodsUsing data from the Prechter Longitudinal Study of Bipolar Disorder, we measured the prevalence and demographic factors of comorbid ED with BD, presence of additional comorbidity of anxiety and substance use disorders, psychosis, suicide attempts, mixed symptoms, childhood abuse, impact of NEO-Personality Inventory (NEO-PI) personality factors, and mood outcome in 354 patients with BD. We analyzed the prevalence of ED using both broad and narrow criteria.Results and discussionED was more common in the Prechter BD sample than the general population, with the majority of those with ED being female. Anxiety disorders, alcohol abuse/dependence, and NEO-PI N5 impulsiveness were independently associated with ED in a multivariable linear regression analysis. BD age at onset was earlier in the ED group than that in the non-ED group and was earlier than the average onset of ED. Anxiety occurred before ED and alcohol use disorders after both BD and ED. Childhood trauma was associated with ED. Impulsivity and anxiety associated with BD may fuel ED and put patients at risk for other impulsivity-related disorders such as alcohol use disorders. ED was associated with more severe and variable moods and more frequent depression. Patients with BD should be regularly screened for ED, anxiety disorders, and alcohol use disorders, and comorbidity should be promptly addressed.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Impulsivity, anxiety, and alcohol misuse in bipolar disorder comorbid with eating disorders

Jen

Saunders

Ornstein

et al. 2013

Int J Bipolar Disord

View full text Add to dashboard Cite

show abstract

“…Further research is needed to consolidate the findings on the gender-specific aspects of rapid cycling and SP status, as these may have particular treatment implications for women (Burt & Rasgon, 2004). Likewise, the prevalence of eating disorders (EDs) in BD is 5-14% and of course is strongly associated with female gender (McElroy et al, 2011;Seixas et al, 2012). In our study, lifetime comorbidity of ED with SPþ was over twice as frequent as ED with SPÀ cases (19% versus 9%).…”

Section: Discussionmentioning

confidence: 65%

Bipolar Disorder with Seasonal Pattern: Clinical Characteristics and Gender Influences

Geoffroy

Bellivier

Scott

et al. 2013

Chronobiology International

View full text Add to dashboard Cite

Bipolar disorder (BD) has a multifactorial etiology with heterogeneous clinical presentations. Around 25% of BD patients may present with a depressive seasonal pattern (SP). However, there are limited scientific data on the prevalence of SP, its clinical manifestations, and any gender influence. Four hundred and fifty-two BD I and II cases (62% female), recruited from three French university-affiliated psychiatric departments, were assessed for SP. Clinical, treatment, and sociodemographic variables were obtained from structured interviews. One hundred and two (23%) cases met DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) criteria for SP, with similar frequency according to gender. Multivariate analysis showed a significant association between SP and BD II (odds ratio [OR] = 1.99, p = 0.01), lifetime history of rapid cycling (OR = 2.05, p = 0.02), eating disorders (OR = 2.94, p = 0.003), and total number of depressive episodes (OR = 1.13, p = 0.002). Seventy-one percent of cases were correctly classified by this analysis. However, when stratifying the analyses by gender, SP was associated with BD II subtype (OR = 2.89, p = 0.017) and total number of depressive episodes (OR = 1.21, p = 0.0018) in males but with rapid cycling (OR = 3.02, p = 0.0027) and eating disorders (OR = 2.60, p = 0.016) in females. This is the first study to identify different associations between SP and clinical characteristics of BD according to gender. The authors suggest that SP represents a potentially important specifier of BD. These findings indicate that seasonality may reflect increased severity or complexity of disorder.

show abstract

“…La comorbilidad bipolar ha sido descrita tanto en pacientes con TCA como en pacientes con SOP (Campos et al, 2011;Fornaro et al, 2010;Jiang et al, 2009;Kemp et al, 2010;Klipstein y Goldberg, 2006;Lunde et al, 2009;McElroy et al, 2005;McElroy et al, 2006;McIntyre et al, 2005;Rodríguez, 2006;Seixas et al, 2012;Tseng et al, 2016;Wildes et al, 2007), y fue confirmada en 13.14% de las mujeres de nuestro estudio. La significativa mayor prevalencia de TB en el grupo SOP (34.1% vs. 7.0%) es evidente, y específicamente la del tipo II, lo que sugeriría un mayor riesgo de bipolaridad si el TCA y el SOP coocurren.…”

Section: Discussionunclassified

“…La mayoría de los estudios sobre prevalencia indagan la presencia de TCA en personas con TB, y son muchos menos los que hacen la exploración inversa: estimar la prevalencia de TB entre pacientes con TCA. Sin embargo, como han señalado diversos autores, la relevancia de esta asociación no solo está en la alta coocurrencia, sino en las implicaciones terapéuticas, especialmente en cuanto a la elección de los fármacos apropiados (Campos, Angst, Cordas y Moreno, 2011;Fornaro et al, 2010;Jiang, Kenna y Rasgon, 2009;Kemp et al, 2010;Klipstein y Goldberg, 2006;Lunde, Fasmer, Akiskal, Akiskal y Oedegaard, 2009;McElroy, Kotwal y Keck, 2006;McElroy, Kotwal, Keck y Akiskal, 2005;McIntyre, Mancini, McCann, Srinivasan y Kennedy, 2005;Rodríguez, 2006;Seixas et al, 2012;Tseng, Chang, Chen, Liao y Chen, 2016;Wildes, Marcus y Fagiolini, 2007). Recientemente, un estudio con genoma ampliado examinó la asociación entre estos dos tipos de patologías (Liu, Bipolar Genome Study, Kelsoe y Greenwood, 2016), indagando la comorbilidad de TCA como un potencial subfenotipo del TB, para identificar variaciones genéticas que sean comunes y únicas para ambos trastornos.…”

Section: Introductionunclassified

Polycystic ovarian syndrome and its potential association with bipolar disorder in patients with eating disorder

Guarín

Rueda²,

Muñoz³

et al. 2017

Revista Mexicana de Trastornos Alimentarios

View full text Add to dashboard Cite

Exploration of polycystic ovarian syndrome (PCOS) in women with eating disorders (ED) is uncommon, and its association with bipolar disorder (BD) has been understudied. The aim of this study was to determine the prevalence of PCOS in women with ED in an outpatient program and to analyze the potential associations with BD. A total of 388 patients (88 with PCOS and 300 without PCOS) aged among 14 to 61 years were included in the study. Pelvic ultrasound, laboratory tests, and physical exams were performed to each participant. Bivariate analyses were carried out between PCOS, BD and other variables such as: psychiatric comorbidities, body mass index and type of ED. An association model was built. PCOS and BD prevalence were 22.7% and 13.1% respectively. The variables associated with PCOS were: BD type II, overweight or obesity and having an ED with binges and/or purges. When obesity and bulimic ED subtypes were controlled, patients with PCOS and BD type have 5.8 times higher risk of BD type II (OR = 5.85; 95% IC = 2.9-11.6). Comorbidities among these three pathologies are frequent, therefore its exploration and management should be considered.

show abstract

Prevalence and clinical impact of eating disorders in bipolar patients

Abstract: ED comorbidities imposed important negative outcomes in bipolar patients. This finding suggests that attention should be given to the presence of EDs in BD patients and that better treatments focused on this population should be developed.

Cited by 24 publications

References 13 publications

Impulsivity, anxiety, and alcohol misuse in bipolar disorder comorbid with eating disorders

Impulsivity, anxiety, and alcohol misuse in bipolar disorder comorbid with eating disorders

Bipolar Disorder with Seasonal Pattern: Clinical Characteristics and Gender Influences

Polycystic ovarian syndrome and its potential association with bipolar disorder in patients with eating disorder

Contact Info

Product

Resources

About