Prevalence and Clinical Implications of Newly Revealed, Asymptomatic Abnormal Ankle-Brachial Index in Patients With Significant Coronary Artery Disease

Lee, Jong‐Young; Lee, Seung-Whan; Lee, Woo Seok; Han, Seungbong; Park, Yong Kyu; Kwon, Chang Hee; Jang, Jeong Yoon; Cho, Young‐Rak; Park, Gyung‐Min; Ahn, Jung‐Min; Kim, Won‐Jang; Park, Duk‐Woo; Kang, Soo–Jin; Kim, Young‐Hak; Lee, Cheol Whan; Park, Seong-Wook; Park, Seung‐Jung

doi:10.1016/j.jcin.2013.08.008

Cited by 65 publications

(65 citation statements)

References 46 publications

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“…In our study, 20 of 133 patients with CAD (15%) were found to have PAD by ankle-brachial index test. This prevalence of PAD was similar to that reported by Lee et al 18 (385 of 2424 patients with CAD [16%]). Blann et al 12 reported sEng levels to be high in 26 patients with PAD.…”

Section: Saita Et Al Soluble Endoglin Levels In Cad 51supporting

confidence: 91%

Plasma Soluble Endoglin Levels Are Inversely Associated With the Severity of Coronary Atherosclerosis—Brief Report

Saita

Miura

Suzuki-Sugihara

et al. 2017

ATVB

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Objective-Transforming growth factor-β inhibits migration and proliferation of endothelial and smooth muscle cells.Endoglin is a transmembrane receptor for transforming growth factor-β1 and transforming growth factor-β3. Endoglin is released into blood as a soluble form (soluble endoglin [sEng]), but plasma sEng levels in patients with coronary artery disease (CAD) have not been elucidated. Approach and Results-We measured plasma sEng levels in 244 patients undergoing coronary angiography. The severity of coronary atherosclerosis was evaluated as the numbers of >50% stenotic vessels and segments. CAD was found in 147 patients, of whom 55 had 1-vessel, 42 had 2-vessel, and 50 had 3-vessel disease. Compared with 97 patients without CAD, 147 with CAD had lower sEng levels (median 4.04 versus 4.37 ng/mL; P<0.005). A stepwise decrease in sEng levels was found based on the number of stenotic vessels: 4.37 in CAD(−), 4.23 in 1-vessel, 4.13 in 2-vessel, and 3.74 ng/mL in 3-vessel disease (P<0.005). sEng levels inversely correlated with the number of stenotic segments (r=−0.25; P<0.001). In multivariate analysis, sEng was an independent factor for 3-vessel disease and CAD. Odds ratios for CAD and 3-vessel disease were 0.97 (95% confidence interval, 0.95-0.99; P<0.02) and 0.96 (95% confidence interval, 0.93-0.99; P<0.01) for a 0.1 ng/mL increase in sEng levels, respectively. Conclusions-Plasma sEng levels were low in patients with CAD, especially 3-vessel disease, and were inversely associated with the severity of coronary atherosclerosis. The study sponsors had no role in the design, analysis, and interpretation of the study. The online-only Data Supplement is available with this article at http://atvb.ahajournals.org/lookup/suppl

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Section: Saita Et Al Soluble Endoglin Levels In Cad 51supporting

confidence: 91%

Plasma Soluble Endoglin Levels Are Inversely Associated With the Severity of Coronary Atherosclerosis—Brief Report

Saita

Miura

Suzuki-Sugihara

et al. 2017

ATVB

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“…2 In patients who underwent diagnostic coronary angiography, an abnormal ABI (≥0.9, ≥1.4) was associated with a significantly higher risk of 3-year composite death, MI and stroke (HR 2.40) compared with a normal ABI. 12 However, some studies have reported inconsistent results with respect to high ABI patients. 13, 15 In the present study, a low ABI was associated with a significantly higher risk of MACE (HR 2.35, 95% CI 1.73-3.17, P<0.0001).…”

Section: Study Limitationsmentioning

confidence: 99%

Clinical Impact of the Ankle-Brachial Index in Patients Undergoing Successful Percutaneous Coronary Intervention

Hiramori

Soga

Kamioka

et al. 2018

Circ J

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“…Патологический уровень ЛПИ может отражать не только явные патоло-гические изменения периферических артерий, но так-же их начальные изменения, которые могут оказать влия-ние на развитие сердечно-сосудистых заболеваний (ССЗ) [9,10]. В последние годы стали обращать внимание на тот факт, что оценка ЛПИ может иметь прогностическое значение в различных когортах обследованных [11], не только в эпидемиологических исследованиях, но и у па-циентов с наличием ССЗ [12]. Недавно опубликованы исследования по прогностическому значению ЛПИ у больных ОНМК [13], однако до сих пор такие иссле-дования проводили в зарубежных странах, отече-ственные исследования ЛПИ при ОНМК только стали появляться, и касаются только отдельных клинических вопросов данной тематики [14].…”

Section: Annual Prognosis After Stroke: Role Of Ankle-brachial Index unclassified

Annual Forecast in Patients With Acute Ischemic Stroke: Role of Pathological Ankle-Brachial Index

Sumin

Kolmykova

Кухарева

et al. 2016

Racionalʹnaâ farmakoterapiâ v kardiologii

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Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Россия 650002, Кемерово, Сосновый бульвар, 6Цель. Изучить факторы, ассоциированные с неблагоприятным годовым прогнозом у больных с острым нарушением мозгового кровообра-щения, и прогностическую роль патологического лодыжечно-плечевого индекса (ЛПИ). Материал и методы. В исследование включено 345 пациентов (возраст 63,6±7,8 лет; 181 мужчин и 164 женщин) с ишемическим инсультом, которые наблюдались в течение 1 года. Пациенты были разделенные на 2 группы. Группа 1 включала пациентов с благоприятным исходом инсульта, а группа 2 -пациентов, которые в течение года имели какие-либо клинические события, в том числе летальный исход. Всем па-циентам проводилось стандартное неврологическое и инструментальное обследование, а также оценка состояния периферических артерий с помощью сфигмоманометрии. Результаты. Группы не различались по возрасту и полу. Частота неблагоприятных исходов (летальный исход, повторное нарушение мозго-вого кровообращения, сердечно-сосудистые события) через 1 год после перенесенного ишемического инсульта составила 29,5%. Наибо-лее часто в группе 2 выявлялись хроническая сердечная недостаточность, фибрилляция предсердий, перенесенные ранее сосудистые события, наличие периферического атеросклероза, избыточная масса тела. Пациенты группы 2 исходно имели более грубый неврологический дефицит. Патологический ЛПИ выявлен у 70,7% пациентов группы 2, в то время как у пациентов группы 1 он выявлен у 33,8% (р=0,000001). При проведении регрессионного анализа выявлена сильная взаимосвязь патологического ЛПИ с неблагоприятным исходом инсульта. Заключение. При ишемическом инсульте патологический ЛПИ позволяет выявить пациентов с периферическим атеросклерозом и прово-дить у них целенаправленные профилактические мероприятия. Стратификация риска может способствовать более эффективной вторичной профилактике у пациентов с цереброваскулярной патологией.Ключевые слова: лодыжечно-плечевой индекс, инсульт, факторы риска, исходы инсульта. Aim. To study the factors associated with a poor annual prognosis in patients with acute stroke and prognostic role of pathological ankle-brachial index (ABI). Material and methods. The study included 345 patients (age 63.6±7.8 years, 181 males and 164 females) with ischemic stroke that were observed for 1 year. All patients were divided into 2 groups: Group 1 included patients with favorable annual outcome of stroke; Group 2 included patients that during a year had any clinical events including death. All patients underwent a standard neurological and instrumental examination including assessment of peripheral arteries status by sphygmomanometry. Results. Both groups did not differ by age and sex. The frequency of unfavorable outcomes (death, re-stroke, cardiovascular events) 1 year after ischemic stroke was 29.5%. Chronic heart failure, atrial fibrillation, previous cardiovascular events, presence of peripheral atherosclerosis, overweight were identified most commonly in Group 2. Patients of Group 2 initi...

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Prevalence and Clinical Implications of Newly Revealed, Asymptomatic Abnormal Ankle-Brachial Index in Patients With Significant Coronary Artery Disease

Abstract: The prevalence of newly revealed abnormal, asymptomatic ABI among patients who have significant CAD on coronary angiography was 15.9%. The presence of abnormal ABI was associated with a higher incidence of adverse clinical outcomes over 3 years.

Cited by 65 publications

References 46 publications

Plasma Soluble Endoglin Levels Are Inversely Associated With the Severity of Coronary Atherosclerosis—Brief Report

Plasma Soluble Endoglin Levels Are Inversely Associated With the Severity of Coronary Atherosclerosis—Brief Report

Clinical Impact of the Ankle-Brachial Index in Patients Undergoing Successful Percutaneous Coronary Intervention

Annual Forecast in Patients With Acute Ischemic Stroke: Role of Pathological Ankle-Brachial Index

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