Prevalence and clinical presentation at the onset of type 1 diabetes mellitus among children and adolescents in AL-Baha region, Saudi Arabia

Alghamdi, Ahmed; Fureeh, Abdelhameed A

doi:10.1515/jpem-2017-0059

Cited by 19 publications

(18 citation statements)

References 11 publications

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“…Multiple characteristics were positively associated with reporting a diagnosis of diabetes among the adolescent study population, including, parental marital status, ever having smoked or used illegal drugs and male gender. Our finding that males were significantly more likely to self-report diabetes than females conflicts with evidence on gender-specific diabetes prevalence rates in the MENA region, with most research showing that the prevalence of T2D [38][39][40] and the incidence rates of T1D are higher among female children and adolescents. 41 42 However, our findings are consistent with a study in Kuwait conducted by Moussa et al 35 among a random sample of school children and adolescents.…”

Section: Discussioncontrasting

confidence: 99%

Prevalence of and risk factors for diabetes mellitus in the school-attending adolescent population of the United Arab Emirates: a large cross-sectional study

et al. 2021

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ObjectivesThe prevalence of diabetes has reportedly increased among adolescents in low-income and middle-income countries of the Middle East and may be linked to social, demographic and economic contextual factors. This study aimed: (1) to estimate the prevalence of self-reported diagnosis of diabetes in the adolescent population of the United Arab Emirates (UAE); (2) to assess differences in the prevalence based on gender and (3) to identify other characteristics of those with diabetes including parental marital status, smoking/illegal drug use, quality of life and nationality.DesignA secondary data analysis was performed on data from the National Study of Population Health in the UAE, conducted between 2007 and 2009.SettingLarge cross-sectional population-based survey study.ParticipantsSurvey was administered to a stratified random sample of 151 public and private schools from the UAE, across 7 emirates. 6365 school-attending adolescents (12–22 years; mean=16 years) participated.OutcomesMultivariable logistic regression analysis was used to examine the relationships between diabetes diagnosis and characteristics of participants after adjusting for confounding from other predictors.ResultsThe overall prevalence of self-reported diabetes was 0.9% (95% CI 0.7% to 1.2%) and was higher in males 1.5% (95% CI 1.0% to 2.1%) than females 0.5% (95% CI 0.3% to 0.8%), (p<0.001). Children of parents who were not currently married had more than twice the odds of self-reporting diabetes (p=0.031) compared with those with married parents. Adolescents who reported ever smoking/using illegal drugs had more than three times the odds of diabetes (p<0.001).ConclusionWe found a positive association between certain characteristics of adolescents and their diabetes status, including male gender, parental marital status and smoking/illegal drug use. The high prevalence of smoking/illegal drug use among those reporting a diagnosis of diabetes suggests the need for behavioural and mental health interventions for adolescents with diabetes, as well as strong parental support and involvement.

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Section: Discussioncontrasting

confidence: 99%

Prevalence of and risk factors for diabetes mellitus in the school-attending adolescent population of the United Arab Emirates: a large cross-sectional study

et al. 2021

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“…18,[25][26][27][28][29][30] However, relatively higher frequencies were reported in other countries such as Saudi Arabia, UK and others. 19,22,27,28,31,32 Current findings also showed that the severity of DKA in pre-school age children was elevated from 7.6% to 33.3% across the study period. The high frequency of severe DKA among preschool age children is in agreement with previous studies conducted in Saudi Arabia, Serbia and Ethiopia.…”

Section: Discussionmentioning

confidence: 60%

“…15,16 However, high frequency of DKA among children with T1DM was reported in countries such as Egypt, Serbia, Saudi Arabia, USA, UK and others. [17][18][19][20][21][22][23][24] The current study showed a trend of increase in the severity of DKA among children with T1DM over the study period with an overall frequency of 12.3%. This frequency is comparable to that reported in Kuwait, Spain, France, Finland and Italy.…”

Section: Discussionmentioning

confidence: 87%

Frequency and severity of ketoacidosis at diagnosis among childhood type 1 diabetes in Khartoum state, Sudan

Ahmed¹,

Khabour²,

Ahmed³

et al. 2020

Afr H. Sci.

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Background: Diabetic ketoacidosis (DKA) is a potentially life threatening acute complication of Type I diabetes mellitus (T1DM). This study aimed to determine the frequency and clinical characteristics of pediatric DKA at diagnosis of new-onset T1DM in Khartoum during 2000- 2017 period. Methods: The study was retrospective and involved review of medical files of children (<15 years) with T1DM in the city hos- pitals and diabetes centers. Results: The overall frequency of DKA among T1DM children at onset of disease diagnosis was 17.6% (173/982). The epi- sodes of DKA increased from 26% in first 6- year period (2000-2005) to 46.3% in the last 6-year period (2011-2012; p<0.001). No significant difference in the frequency of DKA was observed according to gender (p=0.9) and age (p=0.24). Compared to other age groups, the severity of DKA (pH<7.1) was higher in pre-school children (p<0.01). Approximately, 5% of patients were complicated with cerebral edema with a mortality rate of 1.7%. Conclusion: The DKA frequency at diagnosis of childhood T1DM in Khartoum was lower than previous reports. In addition, the severity of DKA was high among pre-school age children with a relatively high mortality rate when compared to the global rate. Keywords: Ketoacidosis; mortality; onset; DKA; T1DM; Sudan; Khartoum.

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“…In a study conducted in the Al-Baha region in Saudi Arabia (58) over 10 years (2007–2016), on 471 children below 19 years of age, the prevalence rate of T1DM was dramatically high at 355, which could be cause for great concern. The female to male ratio in the cohort was 1:1.36 where T1DM was more common among girls at 57.5% compared to 42.5% among boys.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Childhood Diabetes Research in the Middle East Region

et al. 2019

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Background: Diabetes mellitus (DM) is a common chronic disorder in children and is caused by absolute or relative insulin deficiency, with or without insulin resistance. There are several different forms of childhood DM. Children can suffer from neonatal diabetes mellitus (NDM), type 1 diabetes (T1DM), type 2 diabetes (T2DM), Maturity Onset Diabetes of the Young (MODY), autoimmune monogenic, mitochondrial, syndromic and as yet unclassified forms of DM. The Middle East has one of the highest incidences of several types of DM in children; however, it is unclear whether pediatric diabetes is an active area of research in the Middle East and if ongoing, which research areas are of priority for DM in children.Objectives: To review the literature on childhood DM related to research in the Middle East, summarize results, identify opportunities for research and make observations and recommendations for collaborative studies in pediatric DM.Methods: We conducted a thorough and systematic literature review by adhering to a list recommended by PRISMA. We retrieved original papers written in English that focus on childhood DM research, using electronic bibliographic databases containing publications from the year 2000 until October 2018. For our final assessment, we retrieved 429 full-text articles and selected 95 articles, based on our inclusion and exclusion criteria.Results: Our literature review suggests that childhood DM research undertaken in the Middle East has focused mainly on reporting retrospective review of case notes, a few prospective case studies, systemic reviews, questionnaire-based studies, and case reports. These reported studies have focused mostly on the incidence/prevalence of different types of DM in childhood. No studies report on the establishment of National Childhood Diabetes Registries. There is a lack of consolidated studies focusing on national epidemiology data of different types of childhood DM (such as NDM, T1DM, T2DM, MODY, and syndromic forms) and no studies reporting on clinical trials in children with DM.Conclusions: Investing in and funding basic and translational childhood diabetes research and encouraging collaborative studies, will bring enormous benefits financially, economically, and socially for the whole of the Middle East region.

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Prevalence and clinical presentation at the onset of type 1 diabetes mellitus among children and adolescents in AL-Baha region, Saudi Arabia

Cited by 19 publications

References 11 publications

Prevalence of and risk factors for diabetes mellitus in the school-attending adolescent population of the United Arab Emirates: a large cross-sectional study

Prevalence of and risk factors for diabetes mellitus in the school-attending adolescent population of the United Arab Emirates: a large cross-sectional study

Frequency and severity of ketoacidosis at diagnosis among childhood type 1 diabetes in Khartoum state, Sudan

A Systematic Review of Childhood Diabetes Research in the Middle East Region

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