Prevalence and clinical profile of mycoplasma pneumoniae respiratory infection in children: a hospital based study

Cherian, Carol Sara; Nair, Thushara; Sushama, S; Oommen, Seema

doi:10.18203/2349-3291.ijcp20161049

Cited by 2 publications

(1 citation statement)

References 10 publications

(12 reference statements)

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“…About 90.32% cases belonged to age group <5 years and this age group also had a maximum number of positive cases which is in agreement with the epidemiological data based on serological studies [4,13]. Comparison of clinical signs and symptoms between M. pneumoniae-infected and non-infected patients revealed that fever, cough, hurried breathing, with signs of crepitations, intercostal and subcostal retractions were predominant findings in M. pneumoniae-positive patients (Table 1) and are comparable with findings of Chaudhry R et al, [14] Using a combination of PCR and serology, overall 31 of 133 patients included in the present study (23.3%) were found positive and the results are comparable with prevalence rate of 10-30% reported in different studies [14][15][16]. In the present study, maximum samples were positive by serology followed by PCR.…”

Section: Discussionsupporting

confidence: 91%

Detection of Mycoplasma pneumoniae in Children with Respiratory Tract Infections by ELISA and PCR

Basawarajappa¹,

Rangappa²,

Rangaiah³

et al. 2019

SJPM

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Mycoplasma pneumoniae has been well established as a major cause of lower respiratory tract infections (LRTIs) accounting for 10-30% of all cases of community-acquired pneumonia and is clinically indistinguishable from other infectious causes of pneumonia. The study aimed to investigate the occurrence of M. pneumoniae as the etiologic pathogen in LRTIs among children and to compare Polymerase Chain Reaction [PCR] and serology for the diagnosis of M. pneumoniae in community-acquired LRTIs in children. A total of 133 children aged between 6 months and 12 years with signs and symptoms of community-acquired LRTIs attending the Paediatrics OPD, emergency or admitted to the wards of a tertiary care hospital were prospectively enrolled into the study. M. pneumoniae in throat swab samples was detected by conventional PCR, and compared with serology and clinical signs and symptoms. Univariate analyses was conducted to determine the association of M. pneumoniae infection among different categories of patients. 31 out of 133 patients included in the study (23.3%) were positive for M. pneumoniae by any test. Among 31 patients, serology (IgM) was positive in 19 patients (61.2%) and PCR in 12 patients (38.7%); 2 patients were found to be positive by both methods. Fever, cough, hurried breathing and intercostal retraction were the clinical signs and symptoms significantly associated with LRTIs due to M. pneumoniae (P<0.05). A combination of clinical features, PCR and IgM for Mycoplasma pneumoniae is recommended depending upon the duration of illness for optimal diagnosis, timely initiation of therapy and to prevent overuse of macrolides.

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Section: Discussionsupporting

confidence: 91%

Detection of Mycoplasma pneumoniae in Children with Respiratory Tract Infections by ELISA and PCR

Basawarajappa¹,

Rangappa²,

Rangaiah³

et al. 2019

SJPM

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Epidemiology and Clinical Pattern of Mycoplasma Pneumonia in Children Hospitalised With Community Acquired Pneumonia

Kalpana

Lakshmi

et al. 2022

ijsr

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OBJECTIVE: To identify the proportion and clinical pattern of mycoplasma pneumonia among children hospitalised with community acquired pneumonia. METHODS: Study design – descriptive cohort. Children between 2 months to 12 years of age who were hospitalised with symptoms suggestive of community acquired pneumonia were included. Children with community acquired pneumonia whose induced sputum grew mycoplasma in culture were dened as having mycoplasma pneumonia. RESULTS: Among the 268 children included in the study, mycoplasma pneumonia was positive in 33(12.3%) cases. Presenting features like fever (P=0.451), fast breathing (P=0.057), lower chest indrawing (P=0.086) and wheeze (P=0.780) were comparable between the two groups. Signicant cough (P=0.008), crepitations (P=0.024) and hypoxia (P=0.036) were more common in children with non mycoplasma pneumonia. There was no difference in length of stay between Mp patients who did and did not receive an antibiotic with activity against Mp (P=0.680). All mycoplasma positive cases clinically improved and the outcome (ICU admission or invasive mechanical ventilation) was comparable between the two groups (p 0.514). CONCLUSIONS: No clinical or radiological features were characteristic of mycoplasma pneumonia.Clinical course was not altered by use of macrolides.

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Prevalence and clinical profile of mycoplasma pneumoniae respiratory infection in children: a hospital based study

Cited by 2 publications

References 10 publications

Detection of Mycoplasma pneumoniae in Children with Respiratory Tract Infections by ELISA and PCR

Detection of Mycoplasma pneumoniae in Children with Respiratory Tract Infections by ELISA and PCR

Epidemiology and Clinical Pattern of Mycoplasma Pneumonia in Children Hospitalised With Community Acquired Pneumonia

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