Prevalence and clinical profile of patients with restless legs syndrome in Parkinson's disease: A meta-analysis

Maggi, Gianpaolo; Barone, Angelo; Mastromarino, Clara; Santangelo, Gabriella; Vitale, Carmine

doi:10.1016/j.sleep.2024.07.015

Sleep Medicine

2024

DOI: 10.1016/j.sleep.2024.07.015

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Prevalence and clinical profile of patients with restless legs syndrome in Parkinson's disease: A meta-analysis

Gianpaolo Maggi,

Angelo Barone,

Clara Mastromarino

et al.

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2024

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Cited by 1 publication

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Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship

Antelmi,

Lanza,

Mogavero

et al. 2024

Movement Disord Clin Pract

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BackgroundPatients with Parkinson's Disease (PD) frequently exhibit non‐motor symptoms, particularly sleep disturbances. Sleep disorders in PD patients are intricately linked to the pathogenesis and progression of PD itself, exacerbating neurodegenerative processes and worsening patient quality of life.ObjectivesThis review underscores the significance of sleep disorders in PD, highlighting their prevalence, impact on disease progression, and the bidirectional relationship between sleep disruption and neurodegeneration. It aims to enhance clinician awareness for better diagnosis and management of sleep‐related comorbidities in PD.MethodsA comprehensive literature search was conducted in PubMed and Scopus using key terms such as “sleep disorders”, “Parkinson's disease”, “REM sleep behavior disorder”, “restless legs syndrome”, “insomnia”, “obstructive sleep apnea”, “excessive daytime sleepiness”, “circadian rhythm disorders”, “sleep and neurodegeneration”.ResultsSleep disorders are prevalent in PD affecting up to 90% of patients. Conditions such as insomnia, REM sleep behavior disorder, restless legs syndrome, obstructive sleep apnea, excessive daytime sleepiness, and circadian rhythm disorders are commonly reported. These disorders are linked to multifactorial biological mechanisms and are associated with more severe disease phenotypes. Of note, several evidence shows that sleep abnormalities may contribute to neuroinflammation and neurodegeneration, further accelerating the disease course.ConclusionsSleep disturbances are critical non‐motor symptoms in PD. Early diagnosis and tailored management of sleep disorders are essential for improving clinical outcomes and potentially offering neuroprotective benefits.

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Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship

Antelmi,

Lanza,

Mogavero

et al. 2024

Movement Disord Clin Pract

View full text Add to dashboard Cite

show abstract

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Prevalence and clinical profile of patients with restless legs syndrome in Parkinson's disease: A meta-analysis

Cited by 1 publication

References 107 publications

Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship

Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship

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