2011
DOI: 10.4081/reumatismo.2003.256
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Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis

Abstract: Objectives: To evaluate the prevalence and clinical significance of cathepsin G antibodies in patients affected with systemic sclerosis (SSc, scleroderma). Methods: 115 patients affected by SSc, 55 (47,8%) with diffuse scleroderma (dSSc) and 60 (52,2%) with limited scleroderma (lSSc), were tested for cathepsin G antibodies by ELISA method. Moreover these sera were evaluated by indirect immunofluorescence (IIF) on ethanol and formalin fixed human neutrophils. Results: By means of the ELISA method 16 (13,9%) pat… Show more

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“…However, the exact role in scleroderma needs to be clarified. 52,53 The mRNA levels of CTSG increase in peripheral blood mononuclear cells and muscles of dermatomyositis patients. The activity of serum CTSG also increase in dermatomyositis and correlate with creatine kinase and lactate dehydrogenase levels; moreover, patients with Jo-1 auto-antibody have higher activity of CTSG.…”
Section: Cathepsin G and Autoimmune Diseasesmentioning
confidence: 99%
“…However, the exact role in scleroderma needs to be clarified. 52,53 The mRNA levels of CTSG increase in peripheral blood mononuclear cells and muscles of dermatomyositis patients. The activity of serum CTSG also increase in dermatomyositis and correlate with creatine kinase and lactate dehydrogenase levels; moreover, patients with Jo-1 auto-antibody have higher activity of CTSG.…”
Section: Cathepsin G and Autoimmune Diseasesmentioning
confidence: 99%