Prevalence and clinico-mycological profile of vulvovaginal candidiasis in a tertiary care hospital

Samal, Rupal; Vaithy, Anandraj; Kotasthane, Dhananjay Srikanth; Ghose, Seetesh

doi:10.18203/2320-1770.ijrcog20150443

Cited by 6 publications

(10 citation statements)

References 27 publications

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“…This is in contrast to present study's finding. 10 This study reported 7.14% isolates of Candida parapsilosis among VVC cases. Another study done in Iran corroborates this finding as it reported 1% isolates of Candida parapsilosis, which is close to study.…”

Section: Discussionmentioning

confidence: 63%

Identification of various Candida species isolated from patients with vulvovaginal candidiasis attending a tertiary care hospital in North India

et al. 2020

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Background: Vulvovaginal Candidiasis (VVC) is a condition diagnosed in a large proportion of women presenting with complaints of abnormal vaginal discharge. The risk of VVC is high in women with diabetes mellitus, pregnancy, using oral contraceptives or broad-spectrum antibiotics and those having Human Immunodeficiency Virus infection.Objective of the present study was to identify the various species of Candida isolated from patients with Vulvovaginal Candidiasis.Methods: A cross-sectional study was done from January to June 2018. A total of 69 clinically suspected VVC cases were included in the study whose high vaginal swabs were collected and subjected to direct microscopy and cultured on Sabouraud Dextrose Agar (SDA). Creamy white pigmented colonies on SDA were confirmed as Candida by doing Gram’s staining. Speciation of positive cultures was confirmed by conventional methods like Corn Meal agar culture, Germ tube test (GTT), Candida CHROM Agar Medium (CAM), sugar assimilation and fermentation test.Results: Out of 69 clinically suspected VVC cases included in the study, only 14 cultures were positive for Candida species. All the 14 isolates were found to be Non-albicans Candida (NAC). Most common species isolated were Candida glabrata 7(50%), followed by Candida tropicalis 3(21.4%), Candida lusitaniae 3(21.4%), and Candida parapsilosis 1 (7.1%).Conclusions: Candida albicans was known to be the most common causative agent of VVC as it was isolated in 90% cases. However, this study showed that all isolates from VVC were Non-albicans Candida. Therefore, species identification should be done in all microbiology laboratories for accurate diagnosis of VVC.

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Section: Discussionmentioning

confidence: 63%

Identification of various Candida species isolated from patients with vulvovaginal candidiasis attending a tertiary care hospital in North India

et al. 2020

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“…According to our previous study [23], the most common isolate was Candida albicans: 72.81% of all vaginal Candida isolates (383/526). Samal et al [28] reported a 72.58% rate of prevalence of C. albicans and 27.42% of non-albicans Candida spp. C. albicans is the most common isolate in patients with VVC, according to other reports as well [31,32].…”

Section: Aetiology Of Vvc and Association With Microscopic Signs Of Imentioning

confidence: 99%

“…Eckert et al [8] believe that the establishment of clinical signs of inflammation during the examination is significant for VVC diagnosis. Other authors recognize that the clinical symptoms are non-specific and do not allow to distinguish VVC with certainty from other types of vaginitis and vaginosis [28][29][30].…”

Section: Association Between Signs Of Inflammation and Vaginal Infectmentioning

confidence: 99%

Analysis of clinical and microbiological indicators of vulvovaginal candidiasis

Dermendzhiev

Hadzhieva²,

Дерменджиев

et al. 2016

Biotechnology & Biotechnological Equipment

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Vulvovaginal candidiasis (VVC) is the most common vaginal infection. It is considered to be the reason for 15%-30% of all vulvovaginal symptoms. A diagnosis based only on clinical signs and/or on a syndrome-based approach, recommended by some authors and health institutions, is in many cases incorrect. There is no indisputable diagnostic method that guarantees high specificity, sensitivity and predictive value. There is no pathognomonic clinical feature of VVC. The aim of the present study was to assess the role of selected clinical and mycological indicators in the diagnosis of VVC using the standard complex scoring system. The research is retrospective and was conducted in several stages to give a more precise and detailed assessment of the examined clinical and microbiological indicators. Clinical, microbiological and statistical methods were used. The results showed the lowest level of compliance between clinical and laboratory diagnosis in VVC: 67.65%. We did not observe a statistically significant relation between the density of the vaginal smear, inflammation, odour test and VVC (p > 0.05). The results showed a moderate association between the positive yellow swab test and VVC (p < 0.05). A significant positive association was established between VVC and presence of microscopic signs of invasiveness (p < 0.001). The most common isolate was Candida albicans: 72.81% of all vaginal Candida isolates.

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“…VVC is a sexually transmitted infection of vaginal mucosa caused by various species of genus Candida, Candida albicans being the commonest of all. [ 1 ] It is typically described as “white cottage cheese” discharge per vagina with associated vulval and vaginal inflammation. [ 2 ] It is the second most common cause of vaginitis after bacterial vaginosis.…”

Section: Introductionmentioning

confidence: 99%

Antifungal profile of vulvovaginal candidiasis in sexually active females from a tertiary care hospital of Western Rajasthan

Kombade

Abhishek

Mittal

et al. 2021

Journal of Family Medicine and Primary Care

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Introduction: Vulvovaginal candidiasis (VVC) is the commonest form of sexually transmitted infection especially in sexually active females. Various species of Candida i.e., Candida albicans and non-albicans Candida are associated with VVC. More than 75% of women experiences vulvovaginal candidiasis at least once in their lifetime and 10% of it can lead to recurrent VVC. So, this study was planned to evaluate the clinico-mycological profile and antifungal profile of VVC in sexually active female attending tertiary care hospital. Materials and Methods: The present two months study was conducted in sexually active females attending Obstetrics –gynecology OPD with VVC in tertiary care hospital. Two high vaginal swabs were taken and fungal culture was done on SDA agar by standard methods. Identification and antifungal susceptibility testing of candidial isolates were done by standard mycological methods. Results: Most of the patients belonged to younger age group between 18 and 29 years (55%). Lower abdominal pain was the most common symptom after vaginal discharge followed by burning sensation and pruritis. Candida glabrata (15) with 58% of all the isolates was the most common Candida species associated with VVC in this study, followed by Candida albicans (5, 19%). Highest antifungal resistance was observed to itraconazole (81%) followed by amphotericin B (35%) and fluconazole (31%). 81% resistance to itraconazole among Candida glabrata and Candida albicans . Voriconazole was maximum susceptible to all Candida species. Conclusion: This study highlights the incidence of VVC among sexually active females of reproductive age group as its recurrence may result into obstetric complications and even infertility and also enlightens the common Candida species and their antifungal profile, which would help the treating clinicians to formulate local antifungal treatment policy for VVC.

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Prevalence and clinico-mycological profile of vulvovaginal candidiasis in a tertiary care hospital

Cited by 6 publications

References 27 publications

Identification of various Candida species isolated from patients with vulvovaginal candidiasis attending a tertiary care hospital in North India

Identification of various Candida species isolated from patients with vulvovaginal candidiasis attending a tertiary care hospital in North India

Analysis of clinical and microbiological indicators of vulvovaginal candidiasis

Antifungal profile of vulvovaginal candidiasis in sexually active females from a tertiary care hospital of Western Rajasthan

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