Prevalence and Clustering of Congenital Heart Defects Among Boys With Hypospadias

Richard, Melissa A.; Patel, Jenil; Benjamin, Renata H.; Canon, Stephen; Marengo, Lisa; Canfield, Mark A.; Agopian, A. J.; Lupo, Philip J.; Nembhard, Wendy N.

doi:10.1001/jamanetworkopen.2022.24152

Cited by 5 publications

(1 citation statement)

References 64 publications

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“…Environmental risk factors for hypospadias are related to intrauterine growth restriction [4]. It is hypothesized that impaired placental function may also lead to reduced androgen effects through decreased production of human chorionic gonadotropin (hCG) [5].…”

Section: Introductionmentioning

confidence: 99%

Enhancement Risk Disease Cardiovascular in Children with Hypospadias

Putra,

Prayuda,

Suherman

et al. 2023

Int Jou of PHE

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Hypospadias is a congenital disorder in boys due to low fetal androgen hormones. Hypospadias is one of the congenital disorders with the highest prevalence. Several studies have revealed the association of hypospadias with cardiovascular disease. There are still very few studies that summarize cardiovascular manifestations in pediatric hypospadias. Therefore, this study was designed to describe the cardiovascular risk in pediatric patients with hypospadias. Method : Journal searches were carried out through several research databases including Google Scholar, PubMed, and Sciencedirect . The keywords used were "hypospadias", "cardiovascular", and "pediatric". The results of the literature search were 1,543 journals with 20 journals meeting the criteria. Results and Discussion : Hypospadias is one of the second most common congenital abnormalities in men after testicular undescensus . Children born with hypospadias are proven to experience changes in vascular structure, namely increased carotid intima media thickness (CMIT) and are associated with hypertension. Hypospadias patients have impaired endothelial function, decreased vasorelaxation, and increased vasoreactivity. The underlying mechanism is a Rho kinase and ROS dependent process. Conclusion: Children with hypospadias have a higher risk of cardiovascular disease.

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Section: Introductionmentioning

confidence: 99%

Enhancement Risk Disease Cardiovascular in Children with Hypospadias

Putra,

Prayuda,

Suherman

et al. 2023

Int Jou of PHE

View full text Add to dashboard Cite

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Enhancing the Classification of Congenital Heart Defects for Outcome Association Studies in Birth Defects Registries

Stephens,

Benjamin,

Lopez

et al. 2024

Birth Defects Research

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IntroductionTraditional strategies for grouping congenital heart defects (CHDs) using birth defect registry data do not adequately address differences in expected clinical consequences between different combinations of CHDs. We report a lesion‐specific classification system for birth defect registry–based outcome studies.MethodsFor Core Cardiac Lesion Outcome Classifications (C‐CLOC) groups, common CHDs expected to have reasonable clinical homogeneity were defined. Criteria based on combinations of Centers for Disease and Control‐modified British Pediatric Association (BPA) codes were defined for each C‐CLOC group. To demonstrate proof of concept and retention of reasonable case counts within C‐CLOC groups, Texas Birth Defect Registry data (1999–2017 deliveries) were used to compare case counts and neonatal mortality between traditional vs. C‐CLOC classification approaches.ResultsC‐CLOC defined 59 CHD groups among 62,262 infants with CHDs. Classifying cases into the single, mutually exclusive C‐CLOC group reflecting the highest complexity CHD present reduced case counts among lower complexity lesions (e.g., 86.5% of cases with a common atrium BPA code were reclassified to a higher complexity group for a co‐occurring CHD). As expected, C‐CLOC groups had retained larger sample sizes (i.e., representing presumably better‐powered analytic groups) compared to cases with only one CHD code and no occurring CHDs.DiscussionThis new CHD classification system for investigators using birth defect registry data, C‐CLOC, is expected to balance clinical outcome homogeneity in analytic groups while maintaining sufficiently large case counts within categories, thus improving power for CHD‐specific outcome association comparisons. Future outcome studies utilizing C‐CLOC‐based classifications are planned.

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Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities

Rudd

2023

Cancer Chemother Pharmacol

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Cytotoxic chemotherapy remains a key modality in cancer treatment. These therapies, successfully used for decades, continue to transform the lives of cancer patients daily. With the high attrition rate of current oncology drug development, combined with the knowledge that most new therapies do not displace standard-of-care treatments and that many healthcare systems cannot afford these new therapies; cytotoxic chemotherapies will remain an important component of cancer therapy for many years to come. The clinical value of these therapies is often under-appreciated within the pre-clinical cancer research community, where this diverse class of agents are often grouped together as non-specific cellular poisons killing tumor cells based solely upon proliferation rate; however, this is inaccurate. This review article seeks to reaffirm the importance of focusing research efforts upon improving our basic understanding of how these drugs work, discussing their ability to target pan-essential pathways in cancer cells, the relationship of this to the chemotherapeutic window, and highlighting basic science approaches that can be employed towards refining their use.

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Prevalence and Clustering of Congenital Heart Defects Among Boys With Hypospadias

Cited by 5 publications

References 64 publications

Enhancement Risk Disease Cardiovascular in Children with Hypospadias

Enhancement Risk Disease Cardiovascular in Children with Hypospadias

Enhancing the Classification of Congenital Heart Defects for Outcome Association Studies in Birth Defects Registries

Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities

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