Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data

Gilaberte, Yolanda; Pérez-Gilaberte, Juan Blas; Poblador‐Plou, Beatriz; Bliek-Bueno, Kevin; Gimeno‐Miguel, Antonio; Prados‐Torres, Alexandra

doi:10.3390/jcm9061632

Cited by 46 publications

(41 citation statements)

References 47 publications

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“…Another relevant comorbidity in this cluster was anxiety and neuroses, and sensory-processing disorders (hearing loss in women and visual impairment in men). Further studies are needed to research the relationship between these associations, especially in the case of sensory-processing disorders, congenital anomalies and some musculoskeletal diseases in which there are very few studies reporting them 25 , 26 .…”

Section: Discussionmentioning

confidence: 99%

Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort

Carmona-Pírez

Poblador‐Plou

Ioakeim-Skoufa

et al. 2021

Sci Rep

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Chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis, and obstructive sleep apnea (OSA) are amongst the most common treatable and preventable chronic conditions with high morbidity burden and mortality risk. We aimed to explore the existence of multimorbidity clusters in patients with such diseases and to estimate their prevalence and impact on mortality. We conducted an observational retrospective study in the EpiChron Cohort (Aragon, Spain), selecting all patients with a diagnosis of allergic rhinitis, asthma, COPD, and/or OSA. The study population was stratified by age (i.e., 15–44, 45–64, and ≥ 65 years) and gender. We performed cluster analysis, including all chronic conditions recorded in primary care electronic health records and hospital discharge reports. More than 75% of the patients had multimorbidity (co-existence of two or more chronic conditions). We identified associations of dermatologic diseases with musculoskeletal disorders and anxiety, cardiometabolic diseases with mental health problems, and substance use disorders with neurologic diseases and neoplasms, amongst others. The number and complexity of the multimorbidity clusters increased with age in both genders. The cluster with the highest likelihood of mortality was identified in men aged 45 to 64 years and included associations between substance use disorder, neurologic conditions, and cancer. Large-scale epidemiological studies like ours could be useful when planning healthcare interventions targeting patients with chronic obstructive airway diseases and multimorbidity.

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Section: Discussionmentioning

confidence: 99%

Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort

Carmona-Pírez

Poblador‐Plou

Ioakeim-Skoufa

et al. 2021

Sci Rep

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“…Recently, atopic diseases have been reported to be associated with functional GI disorders such as functional dyspepsia and irritable bowel syndrome [ 15 ]. Moreover, adults with AD had higher odds of developing gastroenteritis than those without AD [ 33 , 34 ]. In this study, we found the GI function such as dyspepsia and gastric discomfort correlated with AD symptoms (SCORAD).…”

Section: Discussionmentioning

confidence: 99%

Effect of acupuncture treatment in patients with mild to moderate atopic dermatitis: a randomized, participant- and assessor-blind sham-controlled trial

Park

Lee

Yeom

et al. 2021

BMC Complement Med Ther

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Background Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease that affects 1–3% of adults worldwide. Currently, it is not possible to completely cure AD; therefore, alternative treatments need to be developed to meet the patients’ needs. Here, based on our previous pilot study, we conducted the first confirmatory randomized controlled trial to evaluate the effect of acupuncture in patients with mild to moderate AD. Methods A randomized, participant- and assessor-blinded, sham-controlled trial was designed with an intervention period twice-weekly for 4 weeks and a 4-week follow-up. We equally allocated 36 participants to the verum acupuncture (VA) and sham acupuncture (SA) groups. The main outcome measure was the change in SCORing Atopic Dermatitis index (SCORAD) score before and after treatment. Results A total of 36 participants, aged 19 to 38 years, were enrolled, and 35 were included in the intention-to-treat analyses. The mean change in total SCORAD score differed significantly among the two groups at 4 weeks after randomization (P < .0001): the mean difference was − 11.83 (7.05) in the VA group and 0.45 (7.77) in the SA group. The mean SCORAD score substantially decreased 2-weeks after starting the acupuncture treatment and continued to improve for at least 4 weeks after the end of the treatment in the VA group compared to the SA group (each P < .0001). No serious adverse events were observed. Conclusions Twice-weekly acupuncture treatment was effective in reducing AD symptoms in patients with mild to moderate AD without serious adverse events. Trial registration Clinical Research Information Service Identifier: KCT0002796.

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“…Atopic dermatitis (AD) develops after inflammatory responses against common environmental antigens (Ag) and is a lifelong disease with approximately 10 to 15% prevalence in both children and dogs [ 1 , 2 ]. Pruritus, the hallmark symptom of AD, causes a substantial impact on the quality of life for the dog patients, as well as the dog owners, and affected humans ([ 3 , 4 ] and references therein).…”

Section: Introductionmentioning

confidence: 99%

Mast Cells Limit Ear Swelling Independently of the Chymase Mouse Mast Cell Protease 4 in an MC903-Induced Atopic Dermatitis-Like Mouse Model

Svanberg

Öhlund

et al. 2020

IJMS

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Atopic dermatitis (AD) is a complex, often lifelong allergic disease with severe pruritus affecting around 10% of both humans and dogs. To investigate the role of mast cells (MCs) and MC-specific proteases on the immunopathogenesis of AD, a vitamin D3-analog (MC903) was used to induce clinical AD-like symptoms in c-kit-dependent MC-deficient Wsh−/− and the MC protease-deficient mMCP-4−/−, mMCP-6−/−, and CPA3−/− mouse strains. MC903-treatment on the ear lobe increased clinical scores and ear-thickening, along with increased MC and granulocyte infiltration and activity, as well as increased levels of interleukin 33 (IL-33) locally and thymic stromal lymphopoietin (TSLP) both locally and systemically. The MC-deficient Wsh−/− mice showed significantly increased clinical score and ear thickening albeit having lower ear tissue levels of IL-33 and TSLP as well as lower serum levels of TSLP as compared to the WT mice. In contrast, although having significantly increased IL-33 ear tissue levels the chymase-deficient mMCP-4−/− mice showed similar clinical score, ear thickening, and TSLP levels in ear tissue and serum as the WT mice, whereas mMCP-6 and CPA3 -deficient mice showed a slightly reduced ear thickening and granulocyte infiltration. Our results suggest that MCs promote and control the level of MC903-induced AD-like inflammation.

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Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data

Cited by 46 publications

References 47 publications

Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort

Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort

Effect of acupuncture treatment in patients with mild to moderate atopic dermatitis: a randomized, participant- and assessor-blind sham-controlled trial

Mast Cells Limit Ear Swelling Independently of the Chymase Mouse Mast Cell Protease 4 in an MC903-Induced Atopic Dermatitis-Like Mouse Model

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