Prevalence and Complications of Bicuspid Aortic Valve in Chinese According to Echocardiographic Database

Li, Yijian; Wei, Xin; Zhang, Zhengang; Liao, Yanbiao; He, Jialing; Xiong, Tingting; Yang, Xu; Lv, Wenyu; Ou, Yuanweixiang; Tang, Hong; Feng, Yuan; Chen, Mao

doi:10.1016/j.amjcard.2017.04.025

Cited by 33 publications

(24 citation statements)

References 25 publications

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“…As a potentially devastating complication, infective endocarditis remains a big challenge, 21) especially among young regurgitant BAV patients. The occurrence of endocarditis was 3.2% in the present study, which was in agreement with a recent cross-sectional study by Li et al 22) Similar incidences could be found in follow-up studies by Michelena, et al and Tzemos, et al in 2008, while Roberts reported a much higher occurrence in his pilot BAV autopsy study in 1970. 4,23,24) With growing awareness and improving surveillance, even before the onset of significant aortic valve dysfunction, we could expect better management of BAV valvular ailments and therefore fewer cases of infective endocarditis and overt cardiac remodeling.…”

Section: Discussionsupporting

confidence: 93%

Distribution Patterns of Valvular and Vascular Complications in Bicuspid Aortic Valve

Wang

et al. 2020

Int. Heart J.

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For its high occurrence and elevated risks for aortic valve dysfunction and vascular complications, bicuspid aortic valve (BAV) represents a great health challenge. However, the prevalence and clinical features of BAV in the Chinese population are inadequately illustrated. From January 2011 to December 2015, 3,673 BAV patients with 69.1% male predominance were identified among 325,910 recipients of transthoracic echocardiography in our institution, demonstrating 58.4% overt aortic valve dysfunction, 52.5% ascending aortic dilatation, and 19.2% aortic root dilatation. The prevalence of pure aortic stenosis and mixed aortic valve dysfunction rose strikingly with age (both P < 0.0001), while pure aortic regurgitation showed significant decrease with age (P < 0.0001). Males showed elevated prevalence of pure aortic regurgitation (OR 3.16, 95% CI 2.55-3.91, P < 0.0001) and mixed aortic valve dysfunction than females (OR 1.63, 95% CI 1.23-2.17, P = 0.0008), but lower prevalence of pure aortic stenosis (OR 0.51, 95% CI 0.43-0.60, P < 0.0001). Aortic root dilatation was associated with male gender (OR 5.02, 95% CI 3.74-6.74, P < 0.0001), pure aortic regurgitation (OR 2.61, 95% CI 2.15-3.17, P < 0.0001), and right-left (RL) cusp fusion type (OR 1.98, 95% CI 1.64-2.40, P < 0.0001). Ascending aortic dilatation was associated with an elder age (OR 1.04, 95% CI 1.04-1.05, P < 0.0001), pure aortic stenosis (OR 1.37, 95% CI 1.16-1.61 P = 0.0002), and mixed aortic valve dysfunction (OR 2.51, 95% CI 1.89-3.33, P < 0.0001). Bicuspid aortic stenosis and ascending aortic dilatation demonstrate a similar pattern of age escalation, while aortic regurgitation is more prevalent in younger BAV patients. Aortic root dilatation intervenes closely with a unique phenotypic subgroup of male BAV patients with pure aortic regurgitation and RL fusion type.

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Section: Discussionsupporting

confidence: 93%

Distribution Patterns of Valvular and Vascular Complications in Bicuspid Aortic Valve

Wang

et al. 2020

Int. Heart J.

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“…A recent report about prevalence and complications of BAV in Chinese, suggested that almost half of the patients who were diagnosed BAV had different degrees of aortic valve disease with similar results in western report (Li et al, 2017; Masri et al, 2017b). In the large international registry of 2118 patients with BAV, compared with patients with raphe, the prevalence of aortic stenosis and aortic regurgitation was lower in patients who have no raphe.…”

Section: Bicuspid Valvulopathy: a Complication With High Incidence Ansupporting

confidence: 53%

Bicuspid Aortic Valve: An Update in Morphology, Genetics, Biomarker, Complications, Imaging Diagnosis and Treatment

Liu

Xie

et al. 2019

Front. Physiol.

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The bicuspid aortic valve, a kind of heart disease that comes from parents, has been paid attention around the world. Although most bicuspid aortic valve (BAV) patients will suffer from some complications including aortic stenosis, aortic regurgitation, endocarditis, and heart dysfunction in the late stage of the disease, there is none symptom in the childhood, which restrains us to diagnose and treatment in the onset phase of BAV. Hemodynamic abnormalities induced by the malformations of the valves in BAV patients for a long time will cause BAV-associated aortopathy: including progress aortic dilation, aneurysm, dissection and rupture, cardiac cyst and even sudden death. At present, preventive surgical intervention is the only effective method used in this situation and the diameter of the aorta is the primary reference criterion for surgery. And the treatment effects are always not satisfactory for patients and clinicians. Therefore, we need more methods to evaluate the progression of BAV and the surgery value and the appropriate intervention time by combining basic research with clinical treatment. In this review, advances in morphology, genetic, biomarkers, diagnosis and treatments are summarized, which expects to provide an update about BAV. It is our supreme expectations to provide some evidences for BAV early screening and diagnosis, and in our opinion, personalized surgical strategy is the trend of future BAV treatment.

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“…However, even though BAV patients may have a relative risk of dissection 9 times greater than patients with normal tricuspid aortic valve (TAV), results of the literature converge toward a very moderate absolute risk of acute aortic event. Incidence of aortic dissection in the case of BAV was indeed estimated to 1.5/100,000 patient-years by Michelena et al (2011) and at 18/100,000 patient-years in a recent Chinese cohort by Li et al (2017), much lower than the 2/100 patient-years in the case of Marfan syndrome (Groth et al, 2017).…”

Section: Introductionmentioning

confidence: 89%

Aortic Wall Elastic Properties in Case of Bicuspid Aortic Valve

et al. 2019

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Purpose of the Review Bicuspid aortic valve (BAV) is associated with a significant risk of development of aneurysm and dissection of the ascending thoracic aorta. Development of what is called BAV associated aortopathy is particularly heterogeneous with an uncertain prognosis and with no prognostic biomarkers except for the aortic diameter. This situation leads to an important variability of the therapeutic strategy of this aortopathy. By reviewing the literature on aortic stiffness in the case of BAV, we aimed at evaluating its potential prognostic role in the development of aortic dilatation. Recent Findings Studies evaluating aortic stiffness, with ultrasound or magnetic resonance imaging, converge toward the description of an increased segmental aortic stiffness in BAV patients regardless of age, diameter or aortic level, from the root to the arch. Even though there is a lack of longitudinal studies evaluating the progression of aortic dilatation, new data have recently shown the potential prognostic role of the maximal rate of systolic distension of the aortic wall with magnetic resonance imaging. Summary Although the use of aortic distensibility calculation is a simple evaluation of stiffness that could be easily transposed in daily practice, its interpretation remains uncertain. New arterial stiffening indicators seem more promising but need a stronger validation.

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Prevalence and Complications of Bicuspid Aortic Valve in Chinese According to Echocardiographic Database

Cited by 33 publications

References 25 publications

Distribution Patterns of Valvular and Vascular Complications in Bicuspid Aortic Valve

Distribution Patterns of Valvular and Vascular Complications in Bicuspid Aortic Valve

Bicuspid Aortic Valve: An Update in Morphology, Genetics, Biomarker, Complications, Imaging Diagnosis and Treatment

Aortic Wall Elastic Properties in Case of Bicuspid Aortic Valve

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