Prevalence and Conjugal Transfer of Vancomycin Resistance among Clinical Isolates of Staphylococcus aureus

El-Baky, Rehab Mahmoud Abd

doi:10.9734/air/2014/7142

Cited by 12 publications

(14 citation statements)

References 39 publications

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“…Development of resistance to antibiotics in developing countries, like ours, seems to be mainly related to the unreasonable usage of antibiotics due to their easy availability without prescription at the drug stores, non-optimal use in hospitals, animal husbandry, fisheries and agriculture 20 .…”

Section: Discussionmentioning

confidence: 81%

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Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus in an Egyptian University Hospital

Taha¹,

Badr²,

El-Morsy³

et al. 2019

J Pure Appl Microbiol

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The relative high burden of morbidity and mortality caused by Staphylococcus aureus (SA) in healthcare and community settings is a major concern worldwide. It can cause invasive infections, sepsis and deaths. Despite progress in methicillin-resistant S. aureus (MRSA) prevention in healthcare settings, there is a critical need for assessment of the problem in both healthcare and community settings. This study was conducted for examining the prevalence, risk factors and antimicrobial susceptibility of MRSA in Mansoura University Hospitals (MUHs), Egypt. Samples were collected from patients in MUHs with clinically suspected nosocomial infections. MRSA isolates were identified by the standard bacteriological methods, biochemical reactions and disc diffusion method as recommended by the Clinical & Laboratory Standards Institute (CLSI), then confirmed by MecA gene PCR. A total of 2006 isolates was obtained. SA (32%) was the most frequently isolated pathogen. MRSA (130 isolates) represented 20% of SA and 6.48 % of all isolates. The mecA PCR identified SA as MRSA in 99.2% of cases. MRSA was isolated with another organism (mostly Gram-negative bacilli) from 40.8% of cases while 59.2% of MRSA was isolated alone. The most important reported risk factors for MRSA infections were prolonged hospital stays, recent antibiotic therapy, ICU admission, indwelling devices and presence of surgical sutures. MRSA was resistant to many antibiotics but sensitive to vancomycin in 99.2% of cases. Minimizing exposure to the risk factors with rapid diagnosis of MRSA infections are essential for early initiation of appropriate antibiotic treatment and limitation of the non-optimal use of glycopeptides and deaths.

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Section: Discussionmentioning

confidence: 81%

“…Also, it was stated by Dhanalakshmi, et al 24 that methicillin resistance represented 31.3% of SA isolates. Moreover, Abd El-Baky et al 20 found that methicillin resistance represented 25.4% of SA isolates in the study conducted for documentation of VRSA in the Minia University, Egypt.…”

Section: Discussionmentioning

confidence: 98%

Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus in an Egyptian University Hospital

Taha¹,

Badr²,

El-Morsy³

et al. 2019

J Pure Appl Microbiol

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show abstract

“…According to many studies, the factors such as inadequately treated MRSA infection or colonization with VRE strains, and exposure to vancomycin, careless prescription of antibiotics, availability of antibiotics at the drugstores without prescription, lack of monitoring over nursing practices, extensive surgical procedures, prolonged hospitalization, serious underlying disease such as diabetes, malignancy, and renal failure are cited as the main risk factors for the emergence of VRSA (2,6,40).…”

Section: Discussionmentioning

confidence: 99%

“…The development of antimicrobial resistance in the Middle-East seems to be related to the selective pressure of vancomycin, the main antibiotic available to treat MRSA infections in the region, or due to the irrational application of antibiotics (6,12,14,16).…”

Section: Discussionmentioning

confidence: 99%

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Reports of Vancomycin-Resistant Staphylococcus aureus from Middle East Countries

Rahimipour

Ghazvini

Youssefi

2018

Arch Clin Infect Dis

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Context: Staphylococcus aureus is one of the most important pathogens worldwide. The emergence of methicillin-resistant Staphylococcusaureus (MRSA) made vancomycin as the only therapeutic choice. Due to excessive use of vancomycin, decreased susceptibility and increased resistance against this antibiotic are reported worldwide. The current study aimed at investigating the emergence of vancomycin-resistant Staphylococcus aureus (VRSA) in different regions of the Middle-East. Evidence Acquisition: All reputable databases, such as Google Scholar and PubMed, were screened for articles and abstracts reporting VRSA in the Middle-East by the appropriate keywords. Reliable phenotypic and genotypic studies were included in the current review. Results: Reviewing all articles/abstracts revealed more than 100 reports of VRSA isolates from the Middle-East. Most of the studies did not use the clinical and laboratory standards institute (CLSI) guidelines on VRSA identification. Until 2012, four VRSA strains were reported from Iran, 7 from Egypt, and 1 from Pakistan. From 2012 to 2016, seven VRSA isolates were added to the global statistics from the Middle-East; 1 from Iran and 6 from Egypt. Conclusions: VRSA is a global health threat. According to the expanding reports on the emersion of VRSA, more attention should be paid to the proper prescription of this antibiotic as the only choice for S. aureus infections.

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Detection of VanA type vancomycin resistance among MRSA isolates from an emergency hospital in Egypt

Mashaly

El-Mashad

El-deeb³

2018

Comp Clin Pathol

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Prevalence and Conjugal Transfer of Vancomycin Resistance among Clinical Isolates of Staphylococcus aureus

Cited by 12 publications

References 39 publications

Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus in an Egyptian University Hospital

Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus in an Egyptian University Hospital

Reports of Vancomycin-Resistant Staphylococcus aureus from Middle East Countries

Detection of VanA type vancomycin resistance among MRSA isolates from an emergency hospital in Egypt

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