Prevalence and Correlates of Alcohol Dependence Disorder among TB and HIV Infected Patients in Zambia

O’Connell, Rebecca; Chishinga, Nathaniel; Kinyanda, Eugene; Patel, Vikram; Ayles, Helen; Weiss, Helen A.; Seedat, Soraya

doi:10.1371/journal.pone.0074406

Cited by 27 publications

(59 citation statements)

References 49 publications

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“…This observation is consistent with other literature from the region, 14,25 which suggests an ongoing need for outreach to men. There was also substantial evidence that measures of stigma related to both TB and HIV were correlated with hazardous/harmful alcohol use.…”

Section: Discussionsupporting

confidence: 92%

“…We found a high prevalence of both, a result that is consistent with the limited literature on mental health among individuals with HIV and TB in sub-Saharan Africa. 11,25–27 Depressive symptoms and hazardous/harmful alcohol use appeared to primarily affect distinct groups. Due to the small sample size, we did not formally explore correlates, but individuals who reported both were predominantly men who endorsed higher external stigma about HIV.…”

Section: Discussionmentioning

confidence: 98%

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Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho

Hayes‐Larson

Hirsch‐Moverman

Saito

et al. 2017

int j tuberc lung dis

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SUMMARY SETTING Limited data exist on the prevalence and correlates, including stigma, of mental health conditions, including depressive symptoms and alcohol use, among patients co-infected with tuberculosis (TB) and the human immunodeficiency virus (HIV) in sub-Saharan Africa, despite their negative impact on health outcomes. OBJECTIVE To assess the prevalence and correlates of depressive symptoms and hazardous/harmful alcohol use among TB-HIV patients in the Start TB patients on ART and Retain on Treatment (START) study. DESIGN START, a mixed-methods cluster-randomized trial, evaluated a combination intervention package vs. standard of care (SOC) to improve treatment outcomes in TB-HIV co-infected patients in Lesotho. Moderate/ severe depressive symptoms and hazardous/harmful alcohol use were measured using baseline questionnaire data collected from April 2013 to March 2015. Demographic, psychosocial, and TB- and HIV-related knowledge and attitudes, including stigma, were assessed for association with both conditions using generalized linear mixed models. RESULTS Among 371 participants, 29.8% reported moderate/severe depressive symptoms, and 24.7% reported hazardous/harmful alcohol use; 7% reported both. Depressive symptoms were significantly associated with less education, more difficulty understanding written medical information, non-disclosure of TB, greater TB stigma, and the SOC study arm. Hazardous/harmful alcohol use was significantly associated with male sex, as well as greater TB and external HIV stigma. CONCLUSION Prevalence of depressive symptoms and hazardous/harmful alcohol use were high, suggesting a need for routine screening for, and treatment of, mental health disorders in TB-HIV patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho

Hayes‐Larson

Hirsch‐Moverman

Saito

et al. 2017

int j tuberc lung dis

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“…This is consistent with study finding in Jimma, Zambia and Vietnam which shows male predominance in Khat, Alcohol and Cigarettes smoking [18,26,30]. This could be due to due to social and biological factors or gender difference.…”

Section: Discussionsupporting

confidence: 92%

Substance Use and Associated Factors among Retro Viral Infected (RVI) Patients on Antiretroviral Treatment (ART) at Assela Teaching Hospital

Segni¹,

Teshome²,

Demissie³

2017

J AIDS Clin Res

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Introduction: Use of substances such as alcohol, khat and tobacco has become one of the rising major public health and socio-economic problems worldwide. Many people at risk for or already infected with HIV abuse alcohol, contributing to the difficulties in preventing the spread of the infection and treating infected patients.Objective: The objective of the study was to assess prevalence of Substance use and associated factors among Retro Viral Infected (RVI) Patients on Antiretroviral Treatment (ART) at Assela Teaching Hospital, Assela Ethiopia. Methodology:A cross sectional study was conducted from June to August 2016 among 418 RVI patients who were on ART follow up at Assela Teaching Hospital. The participants were selected systematic random sampling. Socio demographic data and other relevant data was collected using semi structured questionnaire. The data was coded, cleaned and entered using Epi Info 3.5.3 then exported to Statistical Package for the Social science (SPSS) version 21 for further analysis. Descriptive statistics and logistic regression analysis was used. Results:The prevalence of substance use at least once in their lifetime among RVI patient was 27.5% whereas the prevalence of current substance use was 3.8% and Alcohol was predominantly abused drug. Alcohol was the being male and friend or family substance use was strong predictors of substance abuse among the respondents. Conclusion and recommendation:This study revealed that the prevalence of substance use among RVI patient was significant. We recommend that awareness creation about the influence of substance use on HIV by health professionals have invaluable benefit.

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“…Various studies done across the world and India have also shown that use of alcohol increases the risk of Tuberculosis [23] [24]. In addition, both alcohol consumption and HIV infection impairs the host's defense mechanism against Tuberculosis infection and disease [25] [26]. Further, alcohol consumption also affects the adherence to HIV and Tuberculosis treatment.…”

Section: Discussionmentioning

confidence: 99%

Causes of Death among HIV-Infected Adults Registered in Selected Anti-Retroviral Therapy Centers in North-Eastern India

Bhattacharjya¹,

Sahu²,

Patel³

et al. 2015

WJA

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Background: Causes of death related studies in HIV infected population are necessary to devise disease specific preventive interventions at both state and national level HIV programs. This study examines the causes of death among HIV-infected individuals registered at selected Anti-Retroviral Therapy (ART) centers in the era of treatment in north-eastern India. Data and Methods: A retrospective chart review of causes of death was undertaken among HIV-infected patients who were treated between January 2006 and November 2012 at three selected ART centers in Assam, a north-eastern state of India. Reported causes of death were coded as per the guidelines of the International Classification of Diseases (ICD-10) to determine the deaths to standard definitions. Results: Among 5612 HIV-infected patients registered over a period of 71 months, 370 deaths have occurred. Tuberculosis (28%) was the leading cause of death followed by death due to AIDS related complex (11%), wasting syndrome and multiple infections (9% each). Deaths due to selected causes were significantly associated with patient's use of alcohol, WHO clinical stage, CD4 count at the time of diagnosis, presence of opportunistic infections during treatment and ART adherence. Median survival duration was shortest among patients who had CD4 count <50 at the start of ART (2.9 months) and patients who had multiple opportunistic infections during treatment (2.5 months). Discussion: Majority (67%) of deaths in our study were due to AIDS-related causes. Tuberculosis has remained the leading cause of death among the HIV patients on ART. Strengthening the linkages and referral between the HIV and TB program will be crucial to reduce the AIDS-related deaths attributed to tuberculosis.

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Prevalence and Correlates of Alcohol Dependence Disorder among TB and HIV Infected Patients in Zambia

Cited by 27 publications

References 49 publications

Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho

Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho

Substance Use and Associated Factors among Retro Viral Infected (RVI) Patients on Antiretroviral Treatment (ART) at Assela Teaching Hospital

Causes of Death among HIV-Infected Adults Registered in Selected Anti-Retroviral Therapy Centers in North-Eastern India

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