Prevalence and Correlates of Anemia in a Large Cohort of HIV-Infected Women: Women's Interagency HIV Study

Levine, Alexandra M.; Berhane, Kiros; Masri-Lavine, Lena; Sanchez, Maria Lynn; Young, Mary; Augenbraun, Michael; Cohen, Mardge H.; Anastos, Kathryn; Newman, Margaret; Gange, Stephen J.; Watts, Heather

doi:10.1097/00126334-200101010-00004

Cited by 89 publications

(77 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anemia was less prevalent in this population than in previous studies, though still common despite a high rate of antiretroviral use. Some of the findings in this study concur with those published previously, including the association of normal hemoglobin levels with current antiretroviral therapy and macrocytosis, and an association between lymphopenia and lower CD4 counts with anemia 3,4,33 The negative association of macrocytosis with anemia is most likely a reflection of current antiretroviral use, as this is a known effect of zidovudine and d4T. Anemia appeared to be less prevalent in women than in men in this population; this may in part be due to the fact that a lower hemoglobin level was used to define anemia in women.…”

Section: Discussionsupporting

confidence: 92%

Anemia and HIV in the Antiretroviral Era: Potential Significance of Testosterone

Behler

Shade

Gregory

et al. 2005

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

Anemia, the most common hematological disorder in human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), is associated with decreased quality of life and survival. Hypogonadism is prevalent in advanced HIV disease, however, low testosterone levels have not been customarily implicated in HIV-associated anemia. This study was undertaken to determine whether there is a relationship between testosterone levels and androgen use with anemia in HIV, and to characterize other clinical correlates of HIV-associated anemia. This was a cross-sectional, observational study of 200 HIV-positive patients at a public hospital HIV clinic from July 2000 to August 2001. A written questionnaire detailed previous and current medication use, opportunistic infections, and malignancies. Hematological and virological parameters, testosterone, and erythropoietin levels were measured; CD4(+) T lymphocyte count and viral load nadir and peak levels were obtained from the computerized medical record. Anemia was defined as hemoglobin <13.5 g/dl in men and <11.6 g/dl in women. Twenty-four percent of women and 28% of men were anemic. Anemia was associated with lymphopenia (adjusted OR 4.0, 95% CI 1.36-11.80), high erythropoietin levels (adjusted OR 7.73, 95% CI 2.92-20.48), and low testosterone levels (adjusted OR 3.27, 95% CI 1.01-10.60). Anemia was negatively associated with female sex (adjusted OR 0.30, 95% CI 0.11-0.85), current antiretroviral therapy (adjusted OR 0.43, 95% CI 0.20-0.95), current androgen use (adjusted OR 0.20, 95% CI 0.05-0.84), and macrocytosis (adjusted OR 0.23, 95% CI 0.09-0.61). Low testosterone levels may have a positive association and supplemental androgens a negative association with anemia in HIV disease.

show abstract

Section: Discussionsupporting

confidence: 92%

Anemia and HIV in the Antiretroviral Era: Potential Significance of Testosterone

Behler

Shade

Gregory

et al. 2005

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

show abstract

“…This because in urban areas there is good access to the information and knowledge about HIV and in Sudan there are 143 voluntary counselling and testing sites, which are located mainly in urban areas (Elhadi et al 2013). In consistent with our findings, it is proved that HIV can lead to adverse pregnancy outcomes such as preterm birth and anaemia (Levine et al 2001). Our results demonstrating different outcomes in the HIV infected women and non-infected women, but one of the major limitations for this paper the majority of the women was not tested so upgrading awareness effort may help over coming barriers and obstacles surrounding planning and implementation of proper HIV/AIDS programs.…”

Section: Human Immune Deficiency Virus Infection Among Women Represensupporting

confidence: 88%

Human immune deficiency virus (HIV) infection during pregnancy at Gadarif hospital, Eastern Sudan

Adam

Ahmed

Ali

2016

Journal of Obstetrics and Gynaecology

View full text Add to dashboard Cite

This was a prospective study conducted on all pregnant and parturient women attending Gadarif Maternity Hospital, Sudan from January 2009 to December 2013 to investigate the maternal characteristics, pregnancy outcomes and estimate of maternal to child transmission of HIV among HIV infected women. During the study period, there were 26 HIV positive mothers among 6420 tested women yielding an incidence rate of 0.4%. The majority of these 26 infected women were of urban residence (69.2%), presented with normal CD4+ T cell count; ? 350\cu. mm3 (96.2%), had less than secondary education (57.7%) and housewives (84.6%). The mean age (SD) was significantly varied between the sero-positive and sero-negative women, 25.9 (5.7) vs. 36.1 (5.7), p = <0.001. More proportion of infected women had maternal anaemia and gave preterm birth, and none of the newborn babies was HIV infected until the age of 96 weeks. It is thus HIV infected women in eastern Sudan were young and likely desire more children.

show abstract

“…A limitation of this study is that speci® c indicators of iron status, such as serum ferritin, were not measured. Iron de® ciency was also implicated as a common cause of anaemia in a multicentre cohort study of anaemia among HIV-infected women 15 . Future studies are needed to determine the proportion of anaemia that is attributable to iron de® ciency in HIV-infected women.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and cumulative incidence of anaemia among HIV-infected injection drug users

2002

View full text Add to dashboard Cite

Risk factors for anaemia and cumulative incidence of anaemia were examined in a longitudinal cohort study of 622 injection drug users (IDUs) (8885 visits) in Baltimore, Maryland, from 1988 to 2000. At enrollment, 19.6% subjects were anaemic (16.1% of men and 30.5% of women, P<0.0001) and 8.4% had microcytic anaemia (6.7% of men and 14.0% of women, P=0.006). Cumulative incidence of anaemia was 82.2% (87.9% of men and 100% of women, P<0.0001) during a median of 7.5 years follow-up. Factors associated with anaemia included age (per 5 year increase, odds ratio (OR)=1.22; 95% confidence interval (CI): 1.10, 1.36), female gender (OR=1.62; 95% CI: 1.16, 2.27), CD4+ lymphocyte count <200 cells/microl (OR 1.85; 95% CI: 1.52, 2.24), weight loss (OR 1.55; 95% CI: 1.26, 1.91), oral thrush (OR 1.53; 95% CI: 1.21, 1.94), Mycobacterium avium complex infection (OR 1.30; 95% CI: 1.04, 1.64), and zidovudine use (OR 1.24; 95% CI: 1.04, 1.48). Higher body mass index (OR 0.92; 95% CI: 0.88, 0.95) and marijuana use (OR 0.75; 95% CI: 0.61, 0.92) were associated with a lower risk of anaemia. The cumulative incidence of anaemia is high among IDUs, and women are at highest risk of anaemia.

show abstract

Prevalence and Correlates of Anemia in a Large Cohort of HIV-Infected Women: Women's Interagency HIV Study

Cited by 89 publications

References 22 publications

Anemia and HIV in the Antiretroviral Era: Potential Significance of Testosterone

Anemia and HIV in the Antiretroviral Era: Potential Significance of Testosterone

Human immune deficiency virus (HIV) infection during pregnancy at Gadarif hospital, Eastern Sudan

Risk factors and cumulative incidence of anaemia among HIV-infected injection drug users

Contact Info

Product

Resources

About