2015
DOI: 10.1186/s12883-015-0401-6
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Prevalence and correlates of apathy in myotonic dystrophy type 1

Abstract: BackgroundApathy in DM1 has long been acknowledged in clinical practice. However, a major drawback is that the concept has been only sparsely explored in previous specific studies. This study aimed to determine the prevalence of apathy in myotonic dystrophy (DM1), to compare it with facioscapulohumeral dystrophy (FSHD) patients and normal healthy controls, and explore its relationship to psychopathological features and cognitive function.MethodsLevels of apathy in 38 DM1 patients with adult phenotypes were com… Show more

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Cited by 66 publications
(67 citation statements)
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“…Although their study included no controls for the impact of marked motor impairment, this finding adds to a body of work showing that many people with myotonic dystrophy type 1 have cognitive difficulties . Consistent with existing work, a significant proportion of participants in the sample recruited by Fujino et al . demonstrated comorbid behavioral symptoms/changes—with higher levels of apathy and depression apparent in the sample.…”
supporting
confidence: 65%
“…Although their study included no controls for the impact of marked motor impairment, this finding adds to a body of work showing that many people with myotonic dystrophy type 1 have cognitive difficulties . Consistent with existing work, a significant proportion of participants in the sample recruited by Fujino et al . demonstrated comorbid behavioral symptoms/changes—with higher levels of apathy and depression apparent in the sample.…”
supporting
confidence: 65%
“…Affective and depression-like symptoms are frequently observed in DM1 subjects, whereas only few patients fully match the criteria for a depressive disorder [ 16 , 23 ]. Lack of interest (apathetic behaviour), a decreased emotional participation and an increased irritability are common features, also defined as “an emotional imbalance” [ 24 , 25 ].…”
Section: Introductionmentioning
confidence: 99%
“…While it is important that the participants are adequately stimulated throughout all populations, it is particularly important in DM1 since apathy is very frequent in this disease [6]. All of these factors, as well as a highly standardized technique should be respected while evaluating maximal muscle strength.…”
Section: Discussionmentioning
confidence: 99%
“…DM1 is a multisystemic disease, which affects cardiovascular, endocrine, neurological and musculoskeletal systems, to name a few [4]. Neurological affections can include cognitive impairments, daytime sleepiness and apathy [4][5][6]. Skeletal muscles are notably affected and patients with the disease experience slowly progressive muscle atrophy and weakness [4,7].…”
Section: Introductionmentioning
confidence: 99%