Objective:
To compare bone mineral density (BMD) and body composition among adolescents: 1) with atypical anorexia nervosa (AAN) versus anorexia nervosa (AN) and 2) those with and without a prior history of overweight.
Method:
Electronic medical records of patients 9–20 years with AN or AAN who underwent dual-energy x-ray absorptiometry (DXA) scans were retrospectively reviewed and analyzed.
Results:
A total of 286 adolescents with AN or AAN were included. In linear regression models, AAN was associated with greater Z-scores in whole body bone mineral content (BMC, B=0.88, p<0.001), lumbar spine BMD (B=0.79, p=0.002), femoral neck BMD (B=0.670, p=0.009); fat mass index (FMI, B=1.33, p=0.003), and lean body mass index (LBMI, B=1.10, p<0.001) compared to AN, adjusting for age, sex, and duration of illness. A prior overweight history was associated with greater Z-scores in whole body BMC; lumbar spine BMD, total hip BMD, femoral neck BMD, and LBMI.
Discussion:
Adolescents with AAN had higher BMD Z-scores than adolescents with AN; adolescents with a prior overweight history had greater BMD Z-scores than adolescents without a prior overweight history. These findings may inform clinical guidelines for the medical management of AAN.