Prevalence and correlates of low plasma selenium concentrations in peritoneal dialysis patients

Beligaswatta, Chathurika; Sudusinghe, Dinesha; Silva, Sinha De; Davenport, Andrew

doi:10.1016/j.jtemb.2021.126899

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…There is some evidence, mostly from observational studies (37,38), suggesting that some vitamins and trace elements with greater dietary total antioxidant capacity, such as vitamins C and E and zinc (39), may be related to a lower incidence of frailty. Furthermore, C. Beligaswatta et al found a correlation between rising frailty ratios and reduced selenium concentrations (40).…”

Section: Discussionmentioning

confidence: 99%

A Mendelian Randomisation Study to Examine the Causal Associations of Circulating Micronutrient Levels with Frailty Risk

Kuribanjiang,

Min,

Yan

et al. 2023

Preprint

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Background There is some disagreement regarding the association between circulating micronutrient levels and the risk of frailty, according to prior observational research. Using a two-sample Mendelian Randomisation (TSMR) method, we explored the causal relationship between circulating micronutrient levels and the risk of frailty. Methods We gathered and screened instrumental variables (IVs) for eight circulating micronutrients, including selenium, zinc, vitamin B12, vitamin B6, folic acid, and vitamins C, D, and E, from published genome-wide association studies (GWAS) and the IEU OpenGWAS open database. Frailty summary data were generated from meta-analyses of genome-wide association studies (GWAS) found in the UK Biobank (n = 164,610) and Twin Gene (n = 10,616). We ran three studies: a main analysis using independently released GWAS data, a secondary analysis using IVs filtered from OpenGWAS data, and a meta-analysis of the findings from the two MR analyses. Results For circulating levels of the eight micronutrients, the pooled βs were − 0.02 (95% CI: -0.090, 0.001; vitamin C), -0.021 (95% CI: -0.045, 0.001; vitamin B12), 0.029 (95% CI: -0.013, 0.072; folic acid),-0.059 (95% CI: -0.183, -0.065; vitamin D), -0.011 (95% CI: -0.099, 0.075; vitamin E), 0.006 (95% CI: -0.047, 0.061; vitamin B6), 0.004 (95% CI: -0.007, 0.017; zinc) and − 0.005 (95% CI:-0.018, 0.008; selenium). Conclusions To summarize, there is no evidence for a connection between the occurrence of frailty and the eight micronutrients, suggesting that supplementation with these nutrients may have little therapeutic value in preventing frailty.

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Section: Discussionmentioning

confidence: 99%

A Mendelian Randomisation Study to Examine the Causal Associations of Circulating Micronutrient Levels with Frailty Risk

Kuribanjiang,

Min,

Yan

et al. 2023

Preprint

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“…Subjects under hemodialysis with Se levels lower than 82 µg/L (the limit of the lowest interquartile group) had high risk of all-causes of death and infectious disease-associated death [13] . Likewise, subjects under peritoneal dialysis nominated as clinically frail had lower serum Se levels (56 µg/L) and higher CRP than non-frail subjects (70 µg Se/L) [181] . However, as commented for other inflammatory diseases, whether Se-deficiency was part of the cause or only a consequence of the disease is unknown [182] .…”

Section: Se Involvement In the Immune And Inflammatory Responsesmentioning

confidence: 93%

“…The systemic inflammatory response found in rheumatoid arthritis (an autoimmune disease) has been linked with dysplasia and B lymphocyte dysfunction [176] , and with a decrease in serum levels of Se and GPXs in total blood [124] . Hemodialysis is another inflammatory and pro-oxidative condition [177] , [178] , [179] that has been associated with low levels of Se [13] , [180] , [181] . Subjects under hemodialysis with Se levels lower than 82 µg/L (the limit of the lowest interquartile group) had high risk of all-causes of death and infectious disease-associated death [13] .…”

Section: Se Involvement In the Immune And Inflammatory Responsesmentioning

confidence: 99%

Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review

Golin

Tinkov

Aschner

et al. 2023

Journal of Trace Elements in Medicine and Biology

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“…Trace element Se is a key component of various enzymes in the body and plays an important role in reducing oxidative stress and inflammation in dialysis patients [ 172 ]. Se deficiency is common in dialysis patients [ 146 , 173 , 174 ]. In the 1990s, it was reported that there is a certain correlation between Se and serum albumin levels in dialysis patients [ 175 , 176 ].…”

Section: Advances In Research On Trace Elements and Malnutritionmentioning

confidence: 99%

“…including 118 patients on hemodialysis treatment used the 2002 Nutritional Risk Screen (NRS 2002) to assess the nutritional status of patients and showed that lower blood Se levels were independently associated with high nutritional risk in maintenance hemodialysis patients [ 153 ]. A recent report on peritoneal dialysis patients reported that 41.4% of 406 peritoneal dialysis patients had Se deficiency (< 0.8umol/L), and lower Se levels were associated with reduced dietary intake and increased weakness and inflammation [ 174 ]. In addition, Se deficiency is also associated with the risk of all-cause mortality in dialysis patients [ 180 ], severe sleep disorders [ 181 ], and low response to erythropoietin (ESA) [ 182 ].…”

Section: Advances In Research On Trace Elements and Malnutritionmentioning

confidence: 99%

Progress in the study of nutritional status and selenium in dialysis patients

et al. 2023

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Malnutrition is very common in patients with chronic kidney disease, especially in those on maintenance dialysis. Malnutrition is one of the major factors affecting survival and death of dialysis patients, and reducing their activity tolerance and immunity. There are numerous and interacting risk factors for malnutrition, such as reduced nutritional intake, increased energy expenditure, hormonal disorders, and inflammation. Selenium, in the form of selenoproteins, is involved in many physiological processes in the body and plays an important role in maintaining redox homeostasis. Oxidative stress and infection are very common in dialysis patients, and selenium levels in dialysis patients are significantly lower than those in the healthy population. It has been shown that there is a correlation between selenium levels in hemodialysis patients and their nutrition-related indicators, and that selenium supplementation may improve malnutrition in patients. However, further studies are needed to support this conclusion and there is a lack of basic research to further characterize the potential mechanisms by which selenium may improve malnutrition in dialysis patients. The purpose of this review is to provide a comprehensive overview of factors associated with malnutrition in dialysis patients and to describe the progress of research on nutritional status and selenium levels in dialysis patients.

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Prevalence and correlates of low plasma selenium concentrations in peritoneal dialysis patients

Cited by 7 publications

References 33 publications

A Mendelian Randomisation Study to Examine the Causal Associations of Circulating Micronutrient Levels with Frailty Risk

A Mendelian Randomisation Study to Examine the Causal Associations of Circulating Micronutrient Levels with Frailty Risk

Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review

Progress in the study of nutritional status and selenium in dialysis patients

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