Prevalence and correlates of undiagnosed, diagnosed, and total type 2 diabetes among adults in Morocco, 2017

Pengpid, Supa; Peltzer, Karl

doi:10.1038/s41598-022-20368-4

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Various reports have shown that T2DM is closely related to aging, with aging being one of the most vital risk factors for T2DM ( 3 , 4 ). Adipose tissue (AT) is redistributed during aging, which affects the sensitivity of insulin ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…(3) Network analysis, enrichment analysis and sensitivity analysis were used to investigate the underlying mechanisms between oxidative aging and T2DM markers. (4) Relative biological functions of identified oxidative aging markers were further validated across different cancer types. As a result, the underlying mechanisms of T2DM (i.e., nutritional metabolism, inflammatory response, mitochondrial function and protein homeostasis) were integrated, which can also provide key indices in cancers.…”

Section: Introductionmentioning

confidence: 99%

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The oxidative aging model integrated various risk factors in type 2 diabetes mellitus at system level

Chen,

Yao,

Zhao

et al. 2023

Front. Endocrinol.

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BackgroundType 2 diabetes mellitus (T2DM) is a chronic endocrine metabolic disease caused by insulin dysregulation. Studies have shown that aging-related oxidative stress (as “oxidative aging”) play a critical role in the onset and progression of T2DM, by leading to an energy metabolism imbalance. However, the precise mechanisms through which oxidative aging lead to T2DM are yet to be fully comprehended. Thus, it is urgent to integrate the underlying mechanisms between oxidative aging and T2DM, where meaningful prediction models based on relative profiles are needed.MethodsFirst, machine learning was used to build the aging model and disease model. Next, an integrated oxidative aging model was employed to identify crucial oxidative aging risk factors. Finally, a series of bioinformatic analyses (including network, enrichment, sensitivity, and pan-cancer analyses) were used to explore potential mechanisms underlying oxidative aging and T2DM.ResultsThe study revealed a close relationship between oxidative aging and T2DM. Our results indicate that nutritional metabolism, inflammation response, mitochondrial function, and protein homeostasis are key factors involved in the interplay between oxidative aging and T2DM, even indicating key indices across different cancer types. Therefore, various risk factors in T2DM were integrated, and the theories of oxi-inflamm-aging and cellular senescence were also confirmed.ConclusionIn sum, our study successfully integrated the underlying mechanisms linking oxidative aging and T2DM through a series of computational methodologies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The oxidative aging model integrated various risk factors in type 2 diabetes mellitus at system level

Chen,

Yao,

Zhao

et al. 2023

Front. Endocrinol.

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“…Limited physical activity, unhealthy dietary patterns, obesity, and low socioeconomic status have been identified as potential risk factors for diabetes in similar LMIC settings. 9 – 11 However, the specific correlates in the Afghan population remain largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of diabetes and impaired fasting glucose among adults in Afghanistan: Insights from a national survey

Dadras,

Nyaboke Ongosi,

Wang

2024

SAGE Open Medicine

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Objectives: Afghanistan is experiencing an escalating burden of noncommunicable diseases, with diabetes and impaired fasting glucose being of particular concern. To explore the prevalence of diabetes and impaired fasting glucose and associated factors among adult Afghans. Methods: This cross-sectional study used secondary data from a nationally representative survey, conducted in 2018 in Afghanistan. A blood sample was collected from the fingertip and tested through a strip to measure blood glucose. The complex sampling design and sampling weights were accounted for in all analyses to produce representative estimates of the target population in Afghanistan. Results: Of 3890 Afghan adults aged 18–69 years who participated in this survey, 11.07% and 10.32% had diabetes and impaired fasting glucose, respectively. For overweight individuals with abdominal obesity, the risk for diabetes became significantly elevated, with an adjusted relative risk ratio of 2.12 (95% CI: 1.10–4.09). However, the most pronounced effect was observed among individuals classified as having obesity with abdominal obesity with an adjusted relative risk ratio of 2.54 (95% CI: 1.37–4.70). Moreover, high cholesterol level was significantly associated with both impaired fasting glucose (ARRR: 2.52, 95% CI: 1.55–4.12) and diabetes (ARRR: 4.12, 95% CI: 2.59–6.56), whereas high blood pressure was significantly associated with only diabetes (ARRR: 1.82, 95% CI: 1.16–2.86). Conclusions: This investigation provides critical insight into the prevalence of diabetes and IFG among Afghan adults aged 18–69 years. Relative to the global average, the higher prevalence observed calls for specifically designed interventions targeting individuals with cardiometabolic risk factors, such as elevated body mass index, abdominal obesity, hypertension, and hypercholesterolemia.

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Undiagnosed status and associated factors of diabetes mellitus among adults living in eastern Ethiopia: Unmasking a silent killer of prevalence of diabetes mellitus

Zerihun,

Abera,

Kune

et al. 2024

Clinical Epidemiology and Global Health

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Prevalence and correlates of undiagnosed, diagnosed, and total type 2 diabetes among adults in Morocco, 2017

Cited by 5 publications

References 37 publications

The oxidative aging model integrated various risk factors in type 2 diabetes mellitus at system level

The oxidative aging model integrated various risk factors in type 2 diabetes mellitus at system level

Prevalence and correlates of diabetes and impaired fasting glucose among adults in Afghanistan: Insights from a national survey

Undiagnosed status and associated factors of diabetes mellitus among adults living in eastern Ethiopia: Unmasking a silent killer of prevalence of diabetes mellitus

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