Prevalence and correlates of use of complementary and alternative medicine in children with autism spectrum disorder in Europe

Salomone, Erica; Charman, Tony; McConachie, Helen; Warreyn, Petra

doi:10.1007/s00431-015-2531-7

Cited by 56 publications

(71 citation statements)

References 36 publications

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“…Our study’s finding that parents’ use of CHA is more likely for children with ASD who also use medication is consistent with some past research (Owen-Smith et al, 2015; Salomone et al, 2015) and lends some support for our hypothesis that higher services use is correlated with use of CHA. Earlier investigations have, indeed, suggested certain prescription medications (e.g., risperidone) may be efficacious for treating core and associated ASD symptoms (Huffman et al, 2011).…”

Section: Discussionsupporting

confidence: 91%

“…Past research shows parents of children with greater ASD severity or medical complexity (e.g., comorbid gastrointestinal problems, hyperactivity) (Hall & Riccio, 2012; Perrin et al, 2012; Salomone et al, 2015; Valicenti-McDermott et al, 2013) are more likely to use CHA for their child. We accordingly hypothesized that parent-reported ASD severity (i.e., mild vs. moderate or severe) would be associated with use of CHA; however, our study’s results did not show a statistically significant association of parent-reported ASD severity with CHA use.…”

Section: Discussionmentioning

confidence: 99%

“…Parental use of CHA for children with ASD in the United States and Europe ranges from 17.3% (Zuckerman, Lindly, Sinche, & Nicolaidis, 2015) to 47.0% (Salomone, Charman, McConachie, & Warreyn, 2015). In addition, CHA use is more common in children with ASD compared to other children, even those with other developmental disabilities (Akins, Krakowiak, Angkustsiri, Hertz-Picciotto, & Hansen, 2014; Valicenti-McDermott et al, 2013; H.…”

mentioning

confidence: 99%

“…ASD symptomatology (Hall & Riccio, 2012; Hopf, Madren, & Santianni, 2016; Perrin et al, 2012; Salomone et al, 2015; Valicenti-McDermott et al, 2013), greater parent education (Akins et al, 2014; Hall & Riccio, 2012; Hanson et al, 2007; Owen-Smith et al, 2015; Salomone et al, 2015; H. Wong & Smith, 2006), and use of multiple health services (Akins et al, 2014; Owen-Smith et al, 2015; Salomone et al, 2015) are associated with an increased likelihood of parental CHA use for children with ASD.…”

mentioning

confidence: 99%

“…Wong & Smith, 2006), and use of multiple health services (Akins et al, 2014; Owen-Smith et al, 2015; Salomone et al, 2015) are associated with an increased likelihood of parental CHA use for children with ASD. Discrepant findings have, however, emerged about the relationship of age, sex, and race/ethnicity with parental use of CHA for children with ASD (Akins et al, 2014; Hall & Riccio, 2012; Hanson et al, 2007; Hopf et al, 2016; Levy, Mandell, Merhar, Ittenbach, & Pinto-Martin, 2003; Owen-Smith et al, 2015; Perrin et al, 2012; Salomone et al, 2015; Valicenti-McDermott et al, 2013; H. Wong & Smith, 2006; Zuckerman, Lindly, Sinche, et al, 2015).…”

mentioning

confidence: 99%

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Parents’ Use of Complementary Health Approaches for Young Children with Autism Spectrum Disorder

Lindly

Thorburn

Heisler³

et al. 2017

J Autism Dev Disord

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Knowledge of why parents use complementary health approaches (CHA) for children with autism spectrum disorder (ASD) is limited. We conducted a mixed methods study to better understand factors influencing parents' decision to use CHA for ASD. Parent-reported data about CHA use were collected on a probability sample of 352 young children with ASD in Denver, Colorado; Los Angeles, California; or Portland, Oregon. Follow-back interviews were conducted with 31 parents. CHA use was negatively associated with older child age and positively associated with parents' belief ASD has major consequences, living in Portland or Denver, and medication use. Nine themes help explain these results. Study findings may have utility for healthcare providers working with children with ASD and their families regarding CHA.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Parents’ Use of Complementary Health Approaches for Young Children with Autism Spectrum Disorder

Lindly

Thorburn

Heisler³

et al. 2017

J Autism Dev Disord

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Prevalence and Treatment Patterns of Autism Spectrum Disorder in the United States, 2016

et al. 2019

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IMPORTANCE Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Previous surveys have reported a steady increase in ASD prevalence in US children over the past decades. Several behavioral therapies and medications have been developed to treat the symptoms of ASD; however, little is known about the current status of treatment usage for children diagnosed as having ASD. OBJECTIVE To estimate the prevalence and treatment patterns of ASD among US children using nationally representative data. DESIGN, SETTING, AND PARTICIPANTS This study used data from the 2016 National Survey of Children's Health, a nationwide, population-based, cross-sectional survey. We included 43 032 children aged 3 to 17 years. Data were collected through questionnaires completed by a parent or guardian. Data were analyzed from February 2018 to March 2018. MAIN OUTCOMES AND MEASURES Outcome variables included ASD diagnosed by a physician or health professional and the use of behavioral treatment or medication treatment among children with ASD. RESULTS Of the 43 032 included participants, 22 072 (51.3%) were male, and the mean (SD) age was 10.7 (4.4) years. The weighted prevalence of ever-diagnosed ASD and current ASD were 2.79% (95% CI, 2.46-3.12) and 2.50% (95% CI, 2.21-2.79), respectively. The state-level prevalence of ever-diagnosed ASD varied from 1.54% (95% CI, 0.60-2.48) in Texas to 4.88% (95% CI, 2.72-7.05) in Florida. Nationally, about 70% of children with current ASD (70.5%; 95% CI, 65.1-75.8) were treated; 43.3% (95% CI, 37.4-49.2) received behavioral treatment only, 6.9% (95% CI, 3.7-10.1) received medication treatment only, and 20.3% (95% CI, 16.5-24.1) received both behavioral and medication treatments. The remaining 29.5% (95% CI, 24.2-34.9) of children with current ASD did not receive either behavioral or medication treatment. CONCLUSIONS AND RELEVANCE This study showed that the prevalence of ASD in the United States was relatively high, and it varied substantially across US states. Almost 30% of US children with ASD did not receive behavioral or medication treatment, which calls for a critical need to understand and address the barriers for those children to receive appropriate treatments.

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Measurement of urine indolylacroylglycine is not useful in the diagnosis or dietary management of autism

et al. 2016

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Lay AbstractIncreased urinary excretion of indolylacroylglycine (IAG) has been proposed as a useful biomarker for the diagnosis and dietary management of patients with autism spectrum disorder (ASD). It has been suggested that this may be due to abnormal metabolism of tryptophan and/or evidence of increased gut permeability to peptides, and may be a valuable biomarker of a process underlying autism viz. the hypothesis that ASD could be caused by increased gut absorption of neuroactive peptides, derived from gluten in wheat and casein in milk, harmful to the brain. This hypothesis has supported the use of gluten-and casein-free diets in those with ASD, and testing of urine for IAG as a prelude to advising dietary manipulation in individuals with ASD. However, there are conflicting reports of whether or not people with ASD have increased amounts of IAG in their urine, the fundamental finding on which the hypothesis above is built. One recent study found increased IAG in the urine of children with persistent gastrointestinal problems. The present study compares IAG in the urine in children with ASD, children with special needs, and in typically developing children and finds no difference among the groups. Neither was there any difference in those with and without current gastrointestinal problems. We found no evidence of increased IAG excretion or for any link to abnormal tryptophan metabolism and/or gut permeability in children with ASD. The data suggest that the measurement of urinary IAG has no value in the diagnosis of ASD or in the dietary management of patients with ASD. 3 Scientific abstractObjective. To measure urine indolylacroylglycine (IAG) excretion using the IAG:creatinine ratio in children with autism spectrum disorder (ASD) compared with two groups of age matched controls, one with special needs but without ASD (SEN) and one typically developing (TD) and in subgroups with/without current gastrointestinal problems and ASD with and without regression.Participants and methods. IAG:creatinine ratio was measured in the urine of 279 children aged 10-14 years: 129 children with ASD (28 with and 101 without regression), 62 SEN controls and 88 TD controls. The prevalence of gastro-intestinal symptoms (GIS) was recorded.Results. No differences were found in the urine IAG:creatinine ratio among groups ASD, TD and SEN; nor in the ASD groups with/without regression, nor in those with/without GIS.Conclusions. This study finds no evidence of increased urine IAG excretion in children with ASD, with or without GIS or with or without regression. Urinary IAG measurements in children with ASD offer no support for increased presence of neuroactive peptides proposed to result from increased gut permeability. We found measurement of urinary IAG to have no value in the diagnosis of autism or in the dietary management of children with ASD.

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Prevalence and correlates of use of complementary and alternative medicine in children with autism spectrum disorder in Europe

Cited by 56 publications

References 36 publications

Parents’ Use of Complementary Health Approaches for Young Children with Autism Spectrum Disorder

Parents’ Use of Complementary Health Approaches for Young Children with Autism Spectrum Disorder

Prevalence and Treatment Patterns of Autism Spectrum Disorder in the United States, 2016

Measurement of urine indolylacroylglycine is not useful in the diagnosis or dietary management of autism

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