Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients With Mental Illness

Abstract

Introduction: Vitamin D inadequacy or deficiency (VDID) has been reported in a high percentage of otherwise healthy individuals. Factors that may contribute to the high prevalence of VDID in people with mental disorders include diet low in vitamin D, poor sunlight exposure, decrease in cutaneous vitamin D synthesis, intake of certain medications, poor mobility, excessive alcohol intake, and tobacco smoking. VDID has been correlated to a host of adverse conditions, including rickets, osteoporosis, osteomalacia, muscle diseases, depression, cognitive dysfunction, and even certain cancers. Objectives: The purpose of this study was to report the prevalence and correlates of vitamin D inadequacy in a sample of 290 psychiatric patients admitted to inpatient or day hospital treatment at the University of Siena Medical Center. Methods: We retrospectively evaluated the prevalence of VDID in 290 psychiatric inpatients' medical records during the year 2017 and evaluated the correlates of VDID in patients with mental illness. Results: Two hundred and seventy two out of two hundred and ninety patients (94%) showed VDID. Physical activity and regular diet were positively correlated with vitamin D levels whereas age, tobacco smoking, PTH, alkaline phosphatase levels were negatively correlated. Statistically significant differences were found among smokers and non-smokers in all study groups. Conclusions: VDID was highly prevalent in our sample. In addition to vitamin D supplementation, psychosocial intervention able to promote and help sustain physical activity, appropriate diet, quitting smoking and sensible sun exposure to prevent and treat VDID in patients with mental health should be implemented, tested, and introduced in our clinical practice.

Serum Vitamin D Concentrations Are Associated With Depressive Symptoms in Men: The Sixth Korea National Health and Nutrition Examination Survey 2014

“…For instance, dietary intake of vitamin D or sunlight exposure were not measured, and other psychiatric disorders including dementia and anxiety disorders were not evaluated. Additionally, there is evidence that PTH (parathyroid hormone) might also be a confounding factor in the associations assessed here (43). However, it is noteworthy that there is evidence of a negative association between PTH and depression (44).…”

Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka

“…Vitamin D deficiency reported to be high in prevalence among inpatients with mental illness in previous studies [26,27]. Thirty percent of samples had psychiatric conditions and mean 25(OH)-Vit D level (25.63 ng/mL) was less among the participants with psychiatric conditions compared to those not having psychiatric conditions (28.68 ng/ml).…”

Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka.

“…Vitamin D deficiency reported to be high in prevalence among inpatients with mental illness in previous studies (25,26).Thirty percent of sample had psychiatric conditions and mean vitamin D level (25.63 ng/ml) less among the participants with psychiatric conditions compare to who are not having psychiatric conditions (28.68 ng/ml).But this results not showed statistically significant(P-0.076).…”