Prevalence and determinants of declining versus stable hemoglobin levels in whole blood donors

Nasserinejad, Kazem; Rosmalen, Joost van; Hurk, Katja van den; Baart, M. L.; Hoekstra, Trynke; Rizopoulos, Dimitris; Lesaffre, Emmanuel; Kort, Wim de

doi:10.1111/trf.13066

Cited by 21 publications

(32 citation statements)

References 45 publications

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“…Donors in Class III have a high initial Hb value and a moderately declining trajectory, donors in Class IV have moderate initial Hb value and relatively stable trajectory. The results of this study regarding the number of latent classes and the interpretation of each class are supported by a previous study [35]. …”

Section: Hemoglobin Longitudinal Datasupporting

confidence: 88%

“…A Hb value of 8.4 mmol/l (135 g/l) and 7.8 mmol/l (125 g/l) for men and women, respectively, is widely accepted as the lower cut-off value of eligibility for donation to protect donors from anemia [34]. The previous studies showed that some individuals have a fast recovery, which results in a relatively stable trajectory, whereas others have a slow recovery that yields a declining trajectory in their Hb values [35, 36]. …”

Section: Hemoglobin Longitudinal Datamentioning

confidence: 99%

“…However previous studies suggested that describing the total donor population using a single trajectory may oversimplify the complex growth patterns of this population [35, 36]. Therefore, a growth mixture modeling approach, which accounts for different subgroups of donors, seems to be a more appropriate method for capturing differences in Hb trajectories between donors [35, 36]. Here we implemented the R&M criterion with vague priors for the parameters.…”

Section: Hemoglobin Longitudinal Datamentioning

confidence: 99%

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Comparison of Criteria for Choosing the Number of Classes in Bayesian Finite Mixture Models

et al. 2017

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Identifying the number of classes in Bayesian finite mixture models is a challenging problem. Several criteria have been proposed, such as adaptations of the deviance information criterion, marginal likelihoods, Bayes factors, and reversible jump MCMC techniques. It was recently shown that in overfitted mixture models, the overfitted latent classes will asymptotically become empty under specific conditions for the prior of the class proportions. This result may be used to construct a criterion for finding the true number of latent classes, based on the removal of latent classes that have negligible proportions. Unlike some alternative criteria, this criterion can easily be implemented in complex statistical models such as latent class mixed-effects models and multivariate mixture models using standard Bayesian software. We performed an extensive simulation study to develop practical guidelines to determine the appropriate number of latent classes based on the posterior distribution of the class proportions, and to compare this criterion with alternative criteria. The performance of the proposed criterion is illustrated using a data set of repeatedly measured hemoglobin values of blood donors.

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Section: Hemoglobin Longitudinal Datasupporting

confidence: 88%

Section: Hemoglobin Longitudinal Datamentioning

confidence: 99%

Section: Hemoglobin Longitudinal Datamentioning

confidence: 99%

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Comparison of Criteria for Choosing the Number of Classes in Bayesian Finite Mixture Models

et al. 2017

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“…A recent study addressed a similar question by identifying factors associated with declining and stable Hb levels in blood donors. 21 Genome-wide association studies [22][23][24] have identified a number of loci regulating iron levels at a population level, but the value of these loci in predicting iron levels in a donor population is not known. It will be of interest to compare the frequencies of, for example, TMPRSS6 and HFE polymorphisms, which regulate iron levels, in frequent donors to those in the general population or infrequent donors.…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of capillary hemoglobin recovery in nearly 1 200 000 blood donor returns

et al. 2017

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Key Points• We used a registry containing all 1 163 524 blood donor returns that took place in Finland between 2010 and 2015 to evaluate cHb recovery.• Average recovery times for cHb to return to the level of the preceding donation were longer than the minimum allowed donation intervals.Measuring the concentration of capillary hemoglobin (cHb) is a standard procedure before blood donation. To further assess the time period needed for cHb recovery after blood donation and to have a more in-depth understanding of features of recovery, we used datamining tools in a large, retrospective data pool containing all 1 163 524 donor returns that took place in Finland in 2010 to 2015. The results show that the average recovery times for cHb to return back to the level preceding donation were substantially longer, over 200 days in all age groups, than were the minimum allowed donation intervals. cHb recovery was especially poor in women under the age of 30 who returned to donate soon after the minimum allowed donation interval. It was of interest that frequent donors recovered substantially faster, with the average recovery times of ;100 days in men and ;200 days in women, than did infrequent donors, suggesting that there is a subpopulation of donors who can donate frequently without fear of iron deficiency. Return interval in fact explained only 1% of the variation in cHb recovery, which points to unknown, individual features, such as genetic or lifestyle factors, warranting further studies and suggesting that simply extending the allowed donation intervals may not suffice to improve cHb recovery. The study demonstrates that data mining of blood bank records is a powerful tool for depicting features of blood donor population.

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“…However, scientific knowledge on donor adverse reactions has significantly increased in the recent past years. This holds true particularly for causes and prevention of vaso-vagal reactions [24][25][26][27] and iron deficiency [28,29]. A future directive should include preventive measures acknowledged as effective to prevent donor reactions and to make donations safer for the donors.…”

Section: Donor Safetymentioning

confidence: 94%

The revision of the European blood directives: A major challenge for transfusion medicine

Folléa¹,

Aranko²

2015

Transfusion Clinique et Biologique

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Prevalence and determinants of declining versus stable hemoglobin levels in whole blood donors

Cited by 21 publications

References 45 publications

Comparison of Criteria for Choosing the Number of Classes in Bayesian Finite Mixture Models

Comparison of Criteria for Choosing the Number of Classes in Bayesian Finite Mixture Models

Retrospective analysis of capillary hemoglobin recovery in nearly 1 200 000 blood donor returns

The revision of the European blood directives: A major challenge for transfusion medicine

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