Diarrhea is a global public health problem that is the third leading cause of death in under five years, with an estimated 1.7 billion cases in 2023 and 1.8 million deaths from diarrhea diseases every year. To better understand child diarrhea in Cambodia, we examined descriptively temporal and geospatial trends of diarrhea and used multivariate logistic regression to analyze its association with individual and household characteristics and diarrhea among children aged 0-59 months using data from the Cambodia Demographic and Health Survey for 2005 to 2022. The prevalence of diarrhea among children aged 0–59 months decreased from 19.7% in 2005 to 6.2% in 2022. The highest prevalence of childhood diarrhea in Kampong Cham (30.1%), in Mondul Kiri/Ratanak Kiri (24.6%), Battambang/Pailin (20.9%), and Mondul Kiri/Ratanak Kiri (12.9%) for 2005, 2010, 2014 and 2022. After adjusting for other variables, factors independently associated with childhood diarrhea included mothers aged 25-34 years (adjusted odds ratio (AOR) = 0.68; 95% CI: 0.48–0.96), 35-49 years (AOR = 0.60; 95% CI: 0.42–0.87), completed higher education (AOR = 0.61; 95% CI: 0.41–0.91), and employed (AOR = 0.79; 95% CI: 0.72– 0.96). Children were less likely to have diarrhea if they were older than 36 months, richest household (AOR = 0.69; 95% CI: 0.55–0.86), coastal region (AOR = 0.53; 95% CI: 0.41–0.69), born to smoker mothers (AOR = 1.61; 95% CI: 1.25–2.08), had barrier access to healthcare services (AOR = 1.20; 95% CI: 1.07–1.35), or children aged 6–23 months. Diarrhea remains highly prevalent among children in Cambodia. Public health interventions and policies to alleviate diarrhea should be prioritized to address these factors across geographical.