Prevalence and Determinants of Hyperglycemia in Very Low Birth Weight Infants: Cohort Analyses of the NIRTURE Study

Recurrent hypoinsulinemic hyperglycemia in neonatal rats increases PARP-1 and NF-κB expression and leads to microglial activation in the cerebral cortex

“…Hyperglycemia is intermittent in ELBW infants, lasting 10-20% (2-5 h) each day during the first 1-2 wk after birth before it is controlled (36,37). Our study attempted to model this phenomenon by altering metabolic pathways of a term gestation rat pup to determine the effect on the developing brain.…”

“…This was done to mimic the intermittent hyperglycemia in ELBW infants, which often lasts for several hours each day over several days, as mentioned earlier (36,37). Furthermore, we also based our model on an earlier study that showed an intermittent hyperglycemia animal protocol was associated with evidence of oxidative stress in the brain regions (21).…”

Desarrollo y validación de la Escala de Mortalidad Neonatal-9 México para predecir la mortalidad en neonatos críticamente enfermos

“…N i n g u n a d e l a s e s c a l a s p r e v i a m e n t e publicadas involucra la hiperglucemia como factor asociado a la mortalidad. Los niveles de glucosa se elevan debido a que existe una inmadurez en la secreción de insulina 29 y se relacionan con patologías que ocasionan la muerte, como hemorragia intraventricular, sepsis, enterocolitis necrotizante, entre otras. 30 La cohorte de validación del EMN-9 Mex resultó consistente con el grupo de pacientes de la cohorte original, en la que surgieron los ítems que conformaron esta escala.…”

Brain mass estimation by head circumference and body mass methods in neonatal glycaemic modelling and control

“…Hyperglycaemia, the elevation of blood glucose (BG) concentration, is common in extremely preterm infants, typically of 27 weeks gestation or less and is closely correlated with morbidity and mortality [1][2][3]. Hyperglycaemia in neonates is frequently treated with insulin to lower BG concentrations [4].…”

“…Hence, given significant variability between preterm infants and no clinically practical ability to measure it directly, this parameter should be modeled as accurately as feasibly possible. = 0.14 (2) This calculation assumes that brain mass is directly proportional to body mass ( ). Equation (2) is clinically convenient, as it requires only data, which is easily available.…”