Prevalence and determinants of microalbuminuria in children suffering from sickle cell anemia in steady state

Aloni, Michel Ntetani; Mabidi, Jean-Louis L; Ngiyulu, René Makuala; Ekulu, Pépé Mfutu; Mbutiwi, Fiston Ikwa Ndol; Makulo, J.R.; Sumaili, Ernest Kiswaya; Gini-Ehungu, Jean Lambert; Nsibu, Célestin Ndosimao; Nseka, Nazaire Mangani; Lepira, François Bompeka

doi:10.1093/ckj/sfx058

Cited by 22 publications

(22 citation statements)

References 38 publications

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“…Conversely, 9.7% of microalbuminuria patients in our study were aged 2-5 years. Our findings were supported by those of Aloni et al [20] who confirmed the presence of microalbuminuria in patients aged <7 years. This early deterioration of glomerular function could be explained by the presence of certain factors, including a genetic predisposition, fetal hemoglobin (HbF) level, environmental factors, efficacy of medical care, and lifestyle factors associated with developing countries [21].…”

Section: Discussionsupporting

confidence: 93%

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Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

Alzahrani¹,

Algarni²,

Alnashri³

et al. 2020

Cureus

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Objectives: Previous studies have not addressed microalbuminuria in pediatric patients with sickle cell disease (SCD) in Jeddah, Saudi Arabia. This study aimed to determine the prevalence of microalbuminuria and to identify associated risk factors in children with SCD at King Abdulaziz University Hospital.Results: Overall, 42.5% of the patients enrolled were Saudi Arabian and 51% were male. The mean age was 12.4 years, and the highest percentage (40%) was in the age group of 15-18 years. The prevalence of microalbuminuria was 9.6%, and hematuria was present in 8% of cases. The percentage of patients with hematuria was significantly higher in the microalbuminuria group (22.6%) than in the nonmicroalbuminuria group (6.5%; P = 0.007). The percentage of patients with acute chest syndrome was also higher in the microalbuminuria group (26%) than in the nonmicroalbuminuria group (8%; P = 0.005). The percentage of patients with gallbladder stones was higher in the microalbuminuria group (13%) than in the nonmicroalbuminuria group (2.4%; P = 0.014). However, the mean number of blood transfusions was higher in the nonmicroalbuminuria group than in the microalbuminuria group (P = 0.002). Sickle cell nephropathy manifests as microalbuminuria, begins at an early age, occurs in all types of SCD, and is associated with disease severity.

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Section: Discussionsupporting

confidence: 93%

“…However, the side effects of transfusion, such as iron overload, must be considered before starting this process. By contrast, Aloni et al [20] reported that BT is not a significant factor with respect to microalbuminuria.…”

Section: Discussionmentioning

confidence: 87%

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

Alzahrani¹,

Algarni²,

Alnashri³

et al. 2020

Cureus

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“…Conversely, we found that 9.7% of microalbuminuria patients were aged 2-5 years. These findings were supported by Aloni et al 23 Interestingly, when compared the microalbuminuria and non-microalbuminuria groups, there was no statistical difference in terms of age (P =.432), which indicated that age was not a defining variable for both groups. However, age was a defining variable in the progression of microalbuminuria in the affected group.…”

Section: Discussionsupporting

confidence: 73%

“…However, the side effects of transfusion, iron overload, must be considered before starting the process. Aloni et al 23 reported that BT is not a significant factor when comparing bothgroups.…”

Section: Discussionmentioning

confidence: 96%

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease in the King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

Alzahrani¹,

Algarni

Alnashri

et al. 2019

Preprint

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Objectives Studies have not addressed microalbuminuria in the sickle cell disease (SCD) pediatric population in Jeddah, Saudi Arabia. This study aimed to determine the prevalence of microalbuminuria and to identify associated risk factors in children with SCD in the King Abdulaziz University Hospital.Results Overall, 42.5% of the patients enrolled were Saudi Arabian and 51% were boys. Patients' mean age was 12.4 years, and the highest percentage (40%) was in the age group of 15-18 years.The prevalence of microalbuminuria was 9.6%, and hematuria was present in 8% of cases. The percentage of patients with hematuria in the microalbuminuria group (22.6%) was significantly higher than that in the non-microalbuminuria group (6.5%) (P=.007). The percentage of patients with acute chest syndrome was higher in the microalbuminuria group (26%) than in the non-microalbuminuria group (8%) (P=0.005). The percentage of patients with gallbladder stones was higher in the microalbuminuria group (13%) than in the non-microalbuminuria group (2.4%) (P=.014). The mean number of blood transfusions was higher in the non-microalbuminuria group than in the microalbuminuria group (P=.002). Sickle cell nephropathy manifests as microalbuminuria, begins in the early ages of life, occurs in all types of SCD, and is associated with disease severity.

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“…Chronic kidney diseases related to sickle cell anemia may also serve as a factor. SCA patients are known to have progressive decline in kidney function associated with microalbuminuria (Aloni et al, 2017), and in adulthood, a decline in kidney function appears to be progressive from 40 years of age…”

Section: Discussionmentioning

confidence: 99%

Osteopenia and Osteoporosis Assessed by Dual X Absorptiometry in Sickle Cell Anemia Adults Subjects

Kabenkama¹,

Bukumba²,

Kazadi³

et al. 2019

ASIR

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Background:Sickle cell anemia is the most common genetic disease in sub-Saharan Africa. It is an inherited autosomal recessive disorder characterized by chronic hemolysis secondary to falciformation of red blood cells, also responsible of ischemia, bone infarction and accompanied by serious infections and organic lesions.Normal for weight at birth, Sickle cell anemia subjects have low pre puberty growth compared to normal children and also have compromised bone remodeling balance which results in decrease of bone mass and increase of bone fragility. Several studies have established that 37% to 50% of SCA patients were osteopenic or osteoporotic. This study aims to confirm the existence of bone remodeling disorders with osteoporotic translation and to compare the values found in Congolese sickle cell adults subjects to the general population.Methods: Spine and hip DXA were conducted on 270 SS homozygotes aged 18 to 50 years (121 men and 149 women) and 359 AA homozygotes as controls (138 men and 221 women), aged from 18 to 50 years old, who agreed to participate in the study, considered as a control group. AS heterozygotes were not included in the study. Results: AA subjects shows higher density (BMD) and Bone mineral content (BMC) values. Both SCAand AA controls showed the characteristic curve with peak bone mass at the fourth decade of life, followed by a decay with age. The difference in BMD and BMC with the control population ranged from 7.94% to 26.34% (average of 16.02%) which whereas, equivalent of -0.9 to -2 standard deviations.The overall decrease in bone mass rate for -2.5 DS of the T-score was: -28.4% and 33.2% for -2 DS of T-score.Conclusion: SCA subjects shows high rate of osteopenia and osteoporosis and are more likely at risk for fractures.

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Prevalence and determinants of microalbuminuria in children suffering from sickle cell anemia in steady state

Cited by 22 publications

References 38 publications

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease in the King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

Osteopenia and Osteoporosis Assessed by Dual X Absorptiometry in Sickle Cell Anemia Adults Subjects

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