Background: Traditional medicine and herbs are widely used in the Saudi Arabia population. Objectives: Assess the knowledge, attitudes, and practices regarding complementary and alternative medicine (CAM) in a Saudi population. Design: Cross-sectional study Setting: Adults attending an outpatient clinic at King Fahad Medical City, Riyadh, Saudi Arabia. Patients and Methods: A survey questionnaire was used to assess the knowledge, attitudes, and practices concerning CAM. Statistical Analysis: Pearson's chi-square test and t-test. Results: Of 250 respondents, 162 (64.8%) were female. The mean age of the participants was 36.16 ± 11.85 years. Of the respondents, 166 (66.4%) claimed to have knowledge about CAM; 123 stated this knowledge was primarily obtained through social media. A total of 148 respondents (59.2%) practiced CAM, and the most common practices included incantation (36.0%), herbal medicine (33.6%), cupping (33.6%), and honey (27.6%). Most respondents (87.2%), especially older individuals, agreed/strongly agreed that a need for CAM exists, and 217 (86.8%) also agreed/strongly agreed that rules and regulations should be implemented for CAM. A total of 152 respondents (60.8%) believed that CAM is effective, and 74.4% believed that CAM is safe. Women were significantly more likely to use supplements, whereas men were significantly more likely to use camel products. Conclusion: Most of our study population had knowledge about CAM and practiced CAM, particularly older individuals, and more than half of the respondents discussed CAM with health professionals. Old age (>40 years), low education levels, and female sex were linked to a high frequency of CAM usage.