Prevalence and Disease Association of Human Parvovirus B19 in Iran: A Systematic Review

Sabahi, Mohammadmahdi; Salehipour, Arash; Kazemi, Azin; Sadeghi, Mohammadreza; Decaro, Nicola; Mozhgani, Sayed‐Hamidreza; Jalilian, Farid Azizi; Yaghoobi, Mojtaba Hedayat

doi:10.2217/fvl-2019-0046

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…Parvovirus B19 is a common viral infection in Iran [39,40]. The results of one serologic study (2005) [42].…”

Section: Discussionmentioning

confidence: 99%

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Association between parvovirus B19 virus and childhood acute lymphoblastic leukemia: A cross-sectional study in Tehran; Iran

2022

JCEI

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Objective: The propose of study was to determine the viral load of Parvovirus B19 in children with proven acute lymphoblastic leukemia (ALL) Methods: A cross-sectional study designed in pediatric ward of Rasoul-e-Akram Hospital (educational, third referral) in Tehran, Iran (2015 – 2016). Sixty-nine children (mean age: 6.57 ± 4.25 years) in preservative phase of ALL selected. BMA had done, and the viral load for Parvovirus B19 determined by quantitative PCR. Results: Type of ALL was Pre B cell: 76.8%; Pro B cell: 14.5% and T-cell type: 7.8%. Low viral load determined in 18.8% (n=13); intermediate in 39.1% (n=27). High and very high viral load observed in 27.1% 15 (n=15) and 20.3% (n=1) of cases respectively. Viral load was related to Pro B cell type (p = 0.050) and lymphadenopathy (p = 0.040), but not related to gender (p = 0.350) and severity of ALL (p = 0.403); like hepatosplenomegaly, anemia, thrombocytopenia or need to transfusion. Conclusion: Parvovirus B19 is a common viral infection in young Iranian population. Near one-third of childbearing age, women in Iran are at risk for primary Parvovirus B19 infection. Here, to evaluate the possible role of parvovirus B19 Infection in the etiology of ALL, 42 % of ALL cases had high and very high viral load (21.7% and 20.3); the low or intermediate viral load is detectable in all cases. The viral load was related to Pro B cell type of ALL (p = 0.050) and the presence of lymphadenopathy. However, there is no relationship observed between Parvovirus B19 viral load and the severity of ALL and gender. It probably might be due to viral detection in the early stages of the ALL

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“…Parvovirus B19 is a common viral infection in Iran [39,40]. The results of one serologic study (2005) [42].…”

Section: Discussionmentioning

confidence: 99%

“…And 4-54% respectively [38]. [39][40][41]. A possible role considered for parvovirus B19 in the pathogenesis of abortion [42].…”

Section: Introductionmentioning

confidence: 99%

Association between parvovirus B19 virus and childhood acute lymphoblastic leukemia: A cross-sectional study in Tehran; Iran

2022

JCEI

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“…The global prevalence of anti-B19 IgG antibodies ranges from 2 to 15% in 1 to 5 years old, 15 to 60% in 6 to 19 years old, 30 to 60% in adults, and exceeds 85% in the senescent population (6). In Iran, the seroprevalence of anti-B19 IgG antibodies and DNA prevalence in the general population are reported up to 86.6% and 10.8%, respectively (7). In healthy subjects, B19 infection may induce mild pancytopenia, but these alterations are transient, with spontaneous recovery.…”

Section: Introductionmentioning

confidence: 99%

Co-prevalence of Human Parvovirus 4 and Primate Erythroparvovirus 1 (B19) in Sickle Cell Disease and Healthy Populations

Akade,

Azaran,

Keikhaei

et al. 2024

Jundishapur J Microbiol

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Background: Human Parvovirus 4 (P4) is a non-enveloped, single-stranded DNA virus belonging to the Tetraparvovirus genus within the Parvoviridae family. Epidemiologically, P4 exhibits similarities with its well-established family counterpart, primate erythroparvovirus 1 (known as B19), a blood-borne virus implicated in causing aplastic crises in individuals with sickle cell disease (SCD). Despite the acknowledged association with B19, there is a dearth of prior investigations into the prevalence and clinical significance of P4 in SCD patients. Objectives: This study aims to ascertain the prevalence and outcomes of P4, along with exploring the co-prevalence of P4 with B19 in individuals with SCD. Methods: A total of 162 participants were enrolled, comprising 120 individuals with SCD and 45 healthy controls. The prevalence of P4 and B19 DNA was determined utilizing a nested-PCR method. Sequencing was performed on positive samples to validate the diagnosis, and a phylogenetic tree was constructed based on the sequencing results. Correlations in the data were analyzed using statistical methods. Results: The prevalence of P4 and B19, as well as the co-prevalence of these viruses, was significantly higher in SCD patients than in healthy individuals. Moreover, the prevalence of P4 did not exhibit a significant correlation with variables such as age, sex, aplastic crises, or specific complications associated with SCD. Conclusions: Sickle cell disease patients represent a susceptible population for P4 infection, as indicated by the heightened prevalence observed in this study.

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Molecular detection of human parvovirus B19 in umbilical cord blood: Case study of Tehran, Iran

et al. 2021

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Prevalence and Disease Association of Human Parvovirus B19 in Iran: A Systematic Review

Cited by 4 publications

References 40 publications

Association between parvovirus B19 virus and childhood acute lymphoblastic leukemia: A cross-sectional study in Tehran; Iran

Association between parvovirus B19 virus and childhood acute lymphoblastic leukemia: A cross-sectional study in Tehran; Iran

Co-prevalence of Human Parvovirus 4 and Primate Erythroparvovirus 1 (B19) in Sickle Cell Disease and Healthy Populations

Molecular detection of human parvovirus B19 in umbilical cord blood: Case study of Tehran, Iran

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