Prevalence and dissemination of antibiotic resistance genes and coselection of heavy metals in Chinese dairy farms

Zhou, Bo; Wang, Chong; Zhao, Qin; Wang, Yang; Huo, Meijun; Wang, Jundong; Wang, Shaolin

doi:10.1016/j.jhazmat.2016.08.007

Cited by 138 publications

(54 citation statements)

References 54 publications

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“…In both of these cases, the simultaneous release of antibiotics and other selective agents promotes selection of organisms containing resistance genes (He et al, 2016;Liu et al, 2017;Wang, Ben, Yang, Zhang, & Qiang, 2016). This generates opportunities for coselection and fixation of chemical (toxic metals) and resistance determinants in species, and within individual DNA molecules Zhou et al, 2016). An investigation by Di Cesare, Eckert, and Corno (2016) However, developing realistic and flexible models that operate on an environmental scale is a significant challenge (Sommer, Munck, Toft-Kehler, & Andersson, 2017).…”

Section: Resistance Ge Nes In E Arth' S Critical Zonementioning

confidence: 99%

Human dissemination of genes and microorganisms in Earth's Critical Zone

Zhu

Gillings

Simonet

et al. 2017

Global Change Biology

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Earth's Critical Zone sustains terrestrial life and consists of the thin planetary surface layer between unaltered rock and the atmospheric boundary. Within this zone, flows of energy and materials are mediated by physical processes and by the actions of diverse organisms. Human activities significantly influence these physical and biological processes, affecting the atmosphere, shallow lithosphere, hydrosphere, and biosphere. The role of organisms includes an additional class of biogeochemical cycling, this being the flow and transformation of genetic information. This is particularly the case for the microorganisms that govern carbon and nitrogen cycling. These biological processes are mediated by the expression of functional genes and their translation into enzymes that catalyze geochemical reactions. Understanding human effects on microbial activity, fitness and distribution is an important component of Critical Zone science, but is highly challenging to investigate across the enormous physical scales of impact ranging from individual organisms to the planet. One arena where this might be tractable is by studying the dynamics and dissemination of genes for antibiotic resistance and the organisms that carry such genes. Here we explore the transport and transformation of microbial genes and cells through Earth's Critical Zone. We do so by examining the origins and rise of antibiotic resistance genes, their subsequent dissemination, and the ongoing colonization of diverse ecosystems by resistant organisms.

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Section: Resistance Ge Nes In E Arth' S Critical Zonementioning

confidence: 99%

Human dissemination of genes and microorganisms in Earth's Critical Zone

Zhu

Gillings

Simonet

et al. 2017

Global Change Biology

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“…Many previous studies have found a correlation between antibiotic resistance genes and heavy metal pollution (Pal et al, 2017;Zhou et al, 2016). Zhou et al (2016) found that heavy metals (Cu and Zn) participated in the co-selection processes for ARGs in dairy farms. Zn has been reported to co-select for methicillin resistance in S. aureus by horizontal transfer of plasmids containing methicillin and MRGs (mec and czr) (Cavaco, Hasman, & Aarestrup, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Zhou et al. () found that heavy metals (Cu and Zn) participated in the co‐selection processes for ARGs in dairy farms. Zn has been reported to co‐select for methicillin resistance in S. aureus by horizontal transfer of plasmids containing methicillin and MRGs ( mec and czr ) (Cavaco, Hasman, & Aarestrup, ).…”

Section: Introductionmentioning

confidence: 99%

“…Soil is a vast reservoir of antibiotic resistance gene (ARGs) and the exchange of ARGs between soil bacteria and human pathogens in soil has been demonstrated (Forsberg et al, 2012;Zhou et al, 2016). The high risk of transmission of ARGs to the human food chain is recognized as a serious threat to human health (Berendonk et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Mobile genetic elements (MGEs) including transposons, insertion sequence (IS) and plasmids are assumed to propagate ARGs to other bacteria by horizontal gene transfer (HGT) (Chen et al, 2013;Luo, Wang, Lu, Mu, & Mao, 2014). Many previous studies have found a correlation between antibiotic resistance genes and heavy metal pollution (Pal et al, 2017;Zhou et al, 2016). Zhou et al (2016) found that heavy metals (Cu and Zn) participated in the co-selection processes for ARGs in dairy farms.…”

Section: Introductionmentioning

confidence: 99%

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Co‐selection for antibiotic resistance genes is induced in a soil amended with zinc

Yang

Yanpeng

Wang

et al. 2019

Soil Use and Management

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The likelihood of co‐selection for antibiotic resistance induced by heavy metals is a potential threat to human health, however, direct evidence of heavy metal‐induced co‐selection of antibiotic resistance is lacking in soil. By using a metagenomic sequencing approach, zinc (Zn) driven co‐selection of antibiotic resistance genes (ARGs) in soil was investigated through a microcosm experiment where Zn salts were added at different levels. The results showed that the abundance and diversity of ARGs had a tendency to increase along the gradient of increasing Zn contents, with the maximum values recorded in the soil amended with 800 mg Zn kg−1. The abundance of mobile genetic elements (MGEs) such as integrons and insertion sequences was significantly increased by Zn exposure. Network analysis demonstrated significant associations between ARGs and MGEs, suggesting that Zn treatment might enhance the potential for horizontal transfer of ARGs. Furthermore, structural equation models revealed that the types of ARGs were primarily driven by variations in bacterial compositions and Zn exposure, followed by integrons. Thus, these results indicate that added Zn salts considerably changed the diversity, abundance and mobility potential of antibiotic resistance, and imply that application of amendments containing high levels of Zn to soil could be causing the emergence and release of ARGs to the environment, and should be carefully monitored.

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