Prevalence and distribution of cancer of the uterine cervix in Agra District, India

Abstract

The prevalence rates and distribution of dysplasias and cancer of the uterine cervix were studied on 26,110 women in the Agra District of India. Derived incidence rates indicate that Agra is among populations of highest risk for cervical cancer in the world. Early marriage and multiple pregnancies are reiterated as important factors. Hindu women had approximately twice the prevalence of cervical cancer seen among Muslims.

Risk factors related to biological behaviour of precancerous lesions of the uterine cervix

“…It has been observed in Indian situations that Muslims have a lower incidence of cervical cancer than Hindus (Wahi et al, 1972;Jussawala et al, 1971). In this study, however, Muslim women with a significantly earlier age of consummation of marriage did not show significantly higher progression rates than Hindus.…”

“…This communication deals with the biological behaviour of precancerous lesions and the effect of certain sociodemographic and biological factors on the progression of dysplasia to carcinoma in situ. Although several studies are available from India, highlighting the risk factors for invasive cervical cancer (Jussawala et al, 1971;Wahi et al, 1972;Luthra et al, 1975), this study is unique in the sense that it examines the effect of some factors on the progression of dysplasia prospectively as compared to dysplasia that did not progress to carcinoma in situ during the same period. Thus, it highlights the risk modifying effect of these factors on dysplasia.…”

Spectrum of Cervical Cytological Lesions in Premenopausal and Postmenopausal Women

“…It has a long latent phase during which it can be detected as identifiable and treatable premalignant lesions which precede the invasive disease by upto 10 years. [4] The transformation zone is the most common site of initiation of the neoplastic process in it, [5], [6] which is easily amenable to screening by PAP smear. The success story of the Pap smear, in bringing down the incidence of invasive cervical carcinoma is already known.…”

Microphotometric DNA Analysis in Moderate Dysplasia of the Uterine Cervix Correlation to the progression and regression of the lesion

“…Cancer of the uterine cervix is the most common malignant tumor among Indian women (1,2). There is evidence that cancer of the uterine cervix does not arise from a normal epithelium but is preceded by a spectrum of abnormal epithelial changes most commonly termed 'cervical dysplasia' (3,4).…”