Prevalence and Distribution of Coronary Artery Calcification in Asymptomatic United States and Korean Adults　– Cross-Sectional Propensity-Matched Analysis –

Han, Donghee; Hartaigh, Bríain ó; Gransar, Heidi; Lee, Ji Hyun; Choi, Su Yeon; Chun, Eun Ju; Sung, Jidong; Han, Hyuk-Soo; Park, Sung Hak; Callister, Tracy Q.; Lin, Fay Y.; Min, James K.; Chang, Hyuk Jae

doi:10.1253/circj.cj-16-0762

Cited by 14 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a cross-sectional study using the KOICA registry, Han et al [40] investigated ethnic differences related to subclinical coro- , and subjects were classified according to the severity of CACS based on the following: 1) score of 0, 1-100, 101-400, or >400 and 2) >0, the presence of any CAC; >100 (moderate CACS) or >400 (severe CACS). Overall, the prevalence and severity of CAC differed according to ethnicity, i.e., higher in US than in Korean adults, regardless of gender difference.…”

Section: Comparison Of Cacs In Asymptomatic Us and Korean Adultsmentioning

confidence: 99%

Coronary Artery Calcification in the Asian Population: An Overview of the Results from the Korea Initiatives on Coronary Artery Calcification Registry

Lee

Han

Park

et al. 2017

Cardiovasc Imaging Asia

Self Cite

View full text Add to dashboard Cite

Section: Comparison Of Cacs In Asymptomatic Us and Korean Adultsmentioning

confidence: 99%

Coronary Artery Calcification in the Asian Population: An Overview of the Results from the Korea Initiatives on Coronary Artery Calcification Registry

Lee

Han

Park

et al. 2017

Cardiovasc Imaging Asia

Self Cite

View full text Add to dashboard Cite

“…For example, cyclooxygenase-2 inhibitors are not approved for patients with ischemic cardio-cerebral vascular disease because they may increase the risk of cardiovascular events [ 5 – 6 ]; the use of ketamine is associated with higher risk of neurological and psychological events [ 7 – 8 ]; nefopam is not recommend for the elderly because its anticholinergic properties made it “notoriously deliriogenic” [ 8 ]. Therefore, use of these drugs are limited in the elderly who have higher prevalace of cerebral and cardiovascular disaese and are more prone to develop postoperative neuropsychological events [ 5 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Dexmedetomidine in combination with morphine improves postoperative analgesia and sleep quality in elderly patients after open abdominal surgery: A pilot randomized control trial

Wang

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

BackgroundDexmedetomidine in combination with opioids has been used for postoperative analgesia. The purpose of this study was to investigate the impacts of dexmedetomidine supplemented intravenous analgesia on morphine consumption and subjective sleep quality in elderly patients after open abdominal surgery.MethodsThis was a pilot randomized controlled trial. 58 elderly patients (age ≥ 60 years) who underwent open abdominal surgery were randomized to receive either dexmedetomidine supplemented morphine analgesia (0.5 mg/ml morphine plus 2 μg/ml dexmedetomidine in 100 ml normal saline, DEX group) or morphine analgesia (0.5 mg/ml morphine in 100 ml normal saline, CTRL group) for 72 hours after surgery. Patient-controlled analgesia pump was programmed to deliver a 2ml bolus with a lockout interval of 8 minutes and a background infusion at a rate of 1 ml/h. The primary endpoint was 72-hour morphine consumption. Secondary endpoints included pain intensity, subjective sleep quality, and 30-day complications and mortality after surgery.ResultsThe 72-hour morphine consumption was lower in the DEX group than in the CTRL group (median 39.0 mg [interquartile range 37.3, 41.0] in the DEX group vs. 49.0 mg [45.5, 50.0] in the CTRL group; median difference -9.0 mg [95% CI -10.0, -6.0], P < 0.001). The intensity of pain within 48 hours was lower (P<0.001 at 4, 12 and 48 hours, P = 0.007 at 24 hours) whereas the subjective quality of sleep was higher (P = 0.031 during the night of surgery and P<0.001 during the 1st night after surgery, respectively) in the DEX group than in the CTRL group. The incidence of 30-day complications did not differ significantly between groups, but it was slightly lower in the DEX group (P = 0.060). There were no significant differences between groups regarding 30-day mortality and the incidences of adverse events.ConclusionsFor elderly patients after open abdominal surgery, dexmedetomidine supplemented analgesia decreases morphine consumption, improves analgesic effects and subjective sleep quality without increasing adverse events.Trial registrationChinese Clinical Trial Registry ChiCTR-IPR-14005620.

show abstract

“… 34 Furthermore, prevalence of CAD can be significantly different between different ethnicities even after matching for other risk factors. 14 , 36…”

Section: Discussionmentioning

confidence: 99%

“…Some scores derived and initially well validated in Western populations have performed less well in Asian cohorts. 13 , 14 , 15 , 16 , 17 Moreover, as assessing PTP has several limitations, the incorporation of the coronary artery calcium (CAC) score as a gatekeeper to further testing has been proposed. 5 , 6 , 18 , 19 , 20 This is based on robust literature that CAC is not only a predictor of cardiovascular events but of obstructive CAD.…”

mentioning

confidence: 99%

Evaluating the Coronary Artery Disease Consortium Model and the Coronary Artery Calcium Score in Predicting Obstructive Coronary Artery Disease in a Symptomatic Mixed Asian Cohort

Baskaran

Neo

Lee

et al. 2022

JAHA

Self Cite

View full text Add to dashboard Cite

Background The utility of a given pretest probability score in predicting obstructive coronary artery disease (CAD) is population dependent. Previous studies investigating the additive value of coronary artery calcium (CAC) on pretest probability scores were predominantly limited to Western populations. This retrospective study seeks to evaluate the CAD Consortium (CAD2) model in a mixed Asian cohort within Singapore with stable chest pain and to evaluate the incremental value of CAC in predicting obstructive CAD. Methods and Results Patients who underwent cardiac computed tomography and had chest pain were included. The CAD2 clinical model comprised of age, sex, symptom typicality, diabetes, hypertension, hyperlipidemia, and smoking status and was compared with the CAD2 extended model that added CAC to assess the incremental value of CAC scoring, as well as to the corresponding locally calibrated local assessment of the heart models. A total of 522 patients were analyzed (mean age 54±11 years, 43.1% female). The CAD2 clinical model obtained an area under the curve of 0.718 (95% CI, 0.668–0.767). The inclusion of CAC score improved the area under the curve to 0.896 (95% CI, 0.867–0.925) in the CAD2 models and from 0.767 (95% CI, 0.721–0.814) to 0.926 (95% CI, 0.900–0.951) in the local assessment of the heart models. The locally calibrated local assessment of the heart models showed better discriminative performance than the corresponding CAD2 models ( P <0.05 for all). Conclusions The CAD2 model was validated in a symptomatic mixed Asian cohort and local calibration further improved performance. CAC scoring provided significant incremental value in predicting obstructive CAD.

show abstract

Prevalence and Distribution of Coronary Artery Calcification in Asymptomatic United States and Korean Adults　– Cross-Sectional Propensity-Matched Analysis –

Cited by 14 publications

References 33 publications

Coronary Artery Calcification in the Asian Population: An Overview of the Results from the Korea Initiatives on Coronary Artery Calcification Registry

Coronary Artery Calcification in the Asian Population: An Overview of the Results from the Korea Initiatives on Coronary Artery Calcification Registry

Dexmedetomidine in combination with morphine improves postoperative analgesia and sleep quality in elderly patients after open abdominal surgery: A pilot randomized control trial

Evaluating the Coronary Artery Disease Consortium Model and the Coronary Artery Calcium Score in Predicting Obstructive Coronary Artery Disease in a Symptomatic Mixed Asian Cohort

Contact Info

Product

Resources

About

Prevalence and Distribution of Coronary Artery Calcification in Asymptomatic United States and Korean Adults – Cross-Sectional Propensity-Matched Analysis –

Cited by 14 publications

References 33 publications

Coronary Artery Calcification in the Asian Population: An Overview of the Results from the Korea Initiatives on Coronary Artery Calcification Registry

Coronary Artery Calcification in the Asian Population: An Overview of the Results from the Korea Initiatives on Coronary Artery Calcification Registry

Dexmedetomidine in combination with morphine improves postoperative analgesia and sleep quality in elderly patients after open abdominal surgery: A pilot randomized control trial

Evaluating the Coronary Artery Disease Consortium Model and the Coronary Artery Calcium Score in Predicting Obstructive Coronary Artery Disease in a Symptomatic Mixed Asian Cohort

Contact Info

Product

Resources

About

Prevalence and Distribution of Coronary Artery Calcification in Asymptomatic United States and Korean Adults　– Cross-Sectional Propensity-Matched Analysis –