Prevalence and distribution of coronary calcium in asymptomatic Japanese subjects in lung cancer screening computed tomography

Ohmoto-Sekine, Yuki; Yanagibori, Ryoko; Amakawa, Kazuhisa; Ishihara, Makiko; Tsuji, Hiroshi; Ogawa, Kyoko; Ishimura, Rieko; Ishiwata, Sugao; Ohno, Minoru; Yamaguchi, Tetsu; Arase, Yasuji

doi:10.1016/j.jjcc.2015.06.010

Cited by 17 publications

(23 citation statements)

References 32 publications

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“…Among these, 12 studies fulfilled the inclusion criteria and contained all information necessary to create the new CAC score nomogram and were therefore included in this analysis. 10,[14][15][16][17][18][19][20][21][22][23][24] The reasons for exclusion of potentially eligible studies are provided in Supplemental Fig. 1.…”

Section: Search and Selectionmentioning

confidence: 99%

“…A total of 134,336 asymptomatic patients from the western hemisphere were included, 10,14-22 of which 34% were women and 19% were under the age of 45 years. In the analyses of Asians, a total of 33,488 asymptomatic individuals were included, 13,14,23,24 of which 18% were women and 12% were under the age of 45 years.…”

Section: Characteristics Of the Studies Included In The Analysesmentioning

confidence: 99%

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A pooled-analysis of age and sex based coronary artery calcium scores percentiles

Ronde

Khoshiwal

Planken

et al. 2020

Journal of Cardiovascular Computed Tomography

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A B S T R A C TBackground: Age and sex based coronary artery calcium score (CAC) percentiles have been used to improve coronary artery disease (CAD) risk prediction. However, the main limitation of the CACs percentiles currently in use is that they are often based on single studies. We performed a pooled analysis of all available studies that reported on CAC percentiles, in order to develop more generalizable age and sex nomograms. Methods: PubMed/Medline and Embase were searched for studies that reported nomograms of age and sex-based CACs percentiles. Studies were included if they reported data collected among asymptomatic individuals without a history of cardiovascular disease. Absolute CACs for each specific percentile stratum were pooled and new percentiles were generated taking into account the sample size of the study. Results: We found 831 studies, of which 12 met the inclusion criteria. Data on CACs percentiles of 134,336 Western and 33,488 Asians were pooled separately, rendering a weighted CACs percentile nomogram available at https://www.calciumscorecalculator.com. Our weighted percentiles differed by up to 24% from the nomograms in use today. Conclusions: Our pooled age and sex based CACs percentiles based on over 155,000 individuals should provide a measure of risk that is more applicable to a wider population than the ones currently in use and hopefully will lead to better risk assessment and treatment decisions.

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Section: Search and Selectionmentioning

confidence: 99%

Section: Characteristics Of the Studies Included In The Analysesmentioning

confidence: 99%

A pooled-analysis of age and sex based coronary artery calcium scores percentiles

Ronde

Khoshiwal

Planken

et al. 2020

Journal of Cardiovascular Computed Tomography

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“…Notably, none of these publications evaluate the correlation of coronary calcium with cardiovascular morbidity and mortality. The prevalence and distribution of coronary calcium have been described in Japan (21). In a cohort of 1,834 lung cancer screening studies, a non-zero calcium score was detected in 26.9% of all subjects.…”

Section: Asiamentioning

confidence: 99%

Coronary artery calcification in lung cancer screening

Ravenel¹,

Nance²

2018

Transl. Lung Cancer Res.

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Lung cancer screening has been shown in the National Lung Screening Trial (NLST) to result in a statistically significant decrease in lung cancer specific mortality. Also within that trial there was shown to be a 7% decrease in all-cause mortality. While the reasons for this benefit are not entirely clear, it may relate to the detection and treatment of other important findings. Smokers not only have a higher risk of lung cancer, but also increased risk of atherosclerosis. The latter can be detected by the discovery of aortic and/or coronary artery calcium on unenhanced CT. As coronary artery calcium scoring can be used as a screening tool to detect asymptomatic coronary artery atherosclerosis, its detection on lung cancer screening exams has the potential to provide both a teachable moment and treatment aimed at the reduction of major coronary artery events and mortality. In this review we will discuss the use of coronary artery calcium scoring for the detection of atherosclerotic disease and its potential application to lung cancer screening populations.

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“…In 2015, epidemiological data indicated that mortality and incidence rates of pulmonary carcinoma continue to increase . A study employing a Japanese cohort estimated that 26.5% of patients diagnosed with pulmonary carcinoma also had different degrees of coronary heart disease (CHD) . The perioperative risk of cardiovascular events in such patients is estimated to be as high as 4.2% …”

Section: Introductionmentioning

confidence: 99%

“…1 A study employing a Japanese cohort estimated that 26.5% of patients diagnosed with pulmonary carcinoma also had different degrees of coronary heart disease (CHD). 2 The perioperative risk of cardiovascular events in such patients is estimated to be as high as 4.2%. 3,4 In patients with pulmonary carcinoma combined with CHD, percutaneous coronary intervention (PCI) is considered the most effective method to reduce the occurrence of postoperative acute coronary syndrome (ACS).…”

Section: Introductionmentioning

confidence: 99%

Video‐assisted thoracoscopic lobectomy after percutaneous coronary intervention in lung cancer patients with concomitant coronary heart disease

Miao

et al. 2017

Thoracic Cancer

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Background: In recent years, based on clinical observations, the number of lung cancer patients with concomitant coronary heart disease (CHD) has gradually increased. However, because of the requirement of long-term anticoagulant therapy after percutaneous coronary intervention (PCI), some of these patients lose the opportunity for surgical treatment, resulting in tumor progression. The objective of this study was to determine the appropriate timing of video-assisted thoracic surgery (VATS) lobectomy after PCI without increasing perioperative cardiovascular risk. Methods: This study retrospectively analyzed clinical data of patients with a combination of NSCLC and CHD who underwent selective pulmonary lobectomy by VATS in the early postoperative PCI period between 2010 and 2015 at Beijing Chaoyang Hospital, China. Results: Fourteen patients received VATS lobectomy after PCI. The disease had progressed to T stage in two patients after PCI. No perioperative death occurred. Two patients suffered postoperative atrial fibrillation: one had a pulmonary infection, and the other had acute coronary syndrome. All patients recovered and were discharged. Conclusion: For NSCLC patients with severe CHD, the use of VATS lobectomy in the early postoperative PCI period could not only advance the timing of surgery, but may also control perioperative hemorrhage and CHD event risks within acceptable ranges, which could provide more patients with an opportunity to undergo surgical treatment.

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Prevalence and distribution of coronary calcium in asymptomatic Japanese subjects in lung cancer screening computed tomography

Cited by 17 publications

References 32 publications

A pooled-analysis of age and sex based coronary artery calcium scores percentiles

A pooled-analysis of age and sex based coronary artery calcium scores percentiles

Coronary artery calcification in lung cancer screening

Video‐assisted thoracoscopic lobectomy after percutaneous coronary intervention in lung cancer patients with concomitant coronary heart disease

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